Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers . For more than half of the patients, substantial improvements in key functions — such as ability to walk, or to use their hands — were observed Read more
Лечение рака прямой кишки Рак прямой кишки является злокачественной опухолью, которая разрастается из эпителия, который в свою очередь выстилает поверхность прямой кишки. Этот вид рака объединяют с подобным поражением ободочной кишки и называют колоректальным. Этот вид рака занимает 3-е место по частотности и смертности в онкологии. Симптомы рака прямой кишкиСимптомы Read more
A feature of stem cells that determines their value is the ability to self-renew, divide and transform into cells of various organs and tissues in the human body. Stem cells have long been appreciated by physicians, in particular in Germany they have become the basis of a unique method of Read more
Stem-cell derived pancreatic endoderm cells in the treatment of T1DM Finding a way to safely replace the destroyed β-cells of patients with type 1 diabetes mellitus (T1DM) has long been a research goal in the T1DM field. Now, two papers report preliminary findings from an ongoing phase I/II trial in Read more
STEM CELL THERAPY CENTER IN PRAGUE Prague, Czech Republic e-mail: [email protected] During the stem cell program the patient receives highly concentrated bio material which contains 50 000 000 – 150 000 000 stem cells ( depend on the selected package). Video from the laboratory: Description of the laboratory: Biotechnology stem Read more
EudraLexAnnex 15: Qualification and Validation
Researchers have developed a method that can turn back the biological clock on skin cells by 30 years, creating stem cells from mature ones, which could be used to treat skin conditions in the future. In 2007, Shinya Yamanaka at Kyoto University in Japan developed a technique that could transform Read more
1月23日，由566位中国科学院和工程院院士参加投票评选的2001年中国十大科技进展新闻揭晓，其中与生命科学相关的研究占有重要地位。去年12月在美国召开的血液学年会上，干细胞研究是科学家们的重点课题。其研究近年来在生命科学领域取得了突破性进展，从1970年Martin Evans首次从小鼠胚囊中分离出小鼠胚胎干细胞，到原被误认为功能单一的干细胞后被证实具有自我复制能力，且可分化为人体206种组织器官的原始细胞；从1998年在人胚囊内层细胞分离出人的胚胎干细胞到目前通过核移植技术获得的第1例人胚胎干细胞及美国国会就此技术发展前景与生命伦理问题的争议，人们充分认识到，21世纪将是生命再生医学年代，干细胞研究将在此领域内起到重大推动作用。在此，我想谈些有关胚胎干细胞和成体干细胞的比较研究。 体内和体外的研究都表明，人胚胎干细胞能分化成人体的绝大多数细胞类群，诸如神经细胞、心肌、骨骼肌、内皮细胞、胃肠组织、肝细胞、β－胰岛细胞、骨、软骨、造血细胞等。干细胞具有的能够稳定生存增殖并保持多向分化潜能的特性使其在遗传性疾病和组织器官移植领域有着巨大的应用前景。 根据个体发育过程中出现的先后次序不同，干细胞又可分为胚胎干细胞和成体干细胞。胚胎干细胞出现在胚胎发育的胚囊内层，高水平表达端粒酶。因为获取胚胎干细胞、建立胚胎干细胞系必须破坏胚囊，生命的定义目前尚无统一的认识，体外培养产生的胚囊是否具有生命还存在着广泛的争议，所以胚胎干细胞的分离、研究乃至用于临床治疗是否符合伦理道德的问题引起了全世界的广泛争论。一种观点认为受精卵产生就意味着新生命的诞生，破坏胚囊就意味着扼杀了一个新的生命。因此，胚胎干细胞的分离、研究及应用都是违反伦理道德的。也有观点认为尽管胚胎干细胞的分离不符合传统的道德观念，但出于研究目的而分离胚胎干细胞可以被接受。另有一些观点认为，受精卵如果未在母体子宫内生长，就不会发育成为完整的个体，因而不能称其为生命。利用这种体外受精产生的胚胎干细胞进行研究和临床治疗，并不违反伦理道德。 胚胎干细胞继续进行分化，形成具有特定功能的干细胞，如血液干细胞可分化成白细胞、红细胞和血小板，皮肤干细胞可形成各种不同类型的皮肤细胞。这些专门化的干细胞统称多能干细胞。在胎儿、儿童和成人组织中存在的多能干细胞统称“成体干细胞（Adult stem cell）”。最近几年的研究表明，这些干细胞的分化能力远超过传统观点局限的范围。例如骨髓成体干细胞在合适的体内外环境中可长期生长，也可分化为成骨细胞 、软骨细胞、脂肪细胞 、平滑肌细胞 、成纤维细胞、骨髓基质细胞及多种血管内皮细胞。还可形成一种肝脏前体细胞－肝卵园细胞，神经、胶质细胞和心肌细胞。高度纯化的造血干细胞可分化形成肝细胞、内皮细胞和心肌细胞。骨骼肌细胞能分化出造血细胞，中枢神经系统干细胞可形成血液细胞、肌肉和许多其它体细胞。我室也首次报道了来源于骨髓的间充质干细胞分化成造血细胞，重建了造血系统。成体干细胞这种跨系统分化特性称为“可塑性（Plasticity）”。 与胚胎干细胞相比，成体干细胞具有许多优势： 1、 胚胎干细胞具有全能性和可以建系传代等优点，因此理论上应用前景广阔。但实际上由于每个个体的主要组织相容性复合体（MHC）不同，同种异体胚胎干细胞及其分化组织细胞用于临床会引起免疫排斥，因此基于胚胎干细胞的治疗方案要求对患者进行长期免疫抑制剂治疗或将患者的造血系统和外来细胞形成嵌合体。尽管最近有研究证实，人胚胎干细胞能诱导分化成为造血细胞，但小鼠胚胎干细胞的实验表明，来源于胚胎干细胞的造血细胞在体内无法重建造血机制，因而限制了临床应用。为了解决免疫排斥的问题，研究人员探索将患者的体细胞核移植到去核的健康供体卵细胞中，在体外克隆并随后发育分化产生携带患者自己MHC的胚胎干细胞。这些胚胎干细胞及其衍生组织移植后不会产生免疫排斥，因此可以用于患者病变组织及其功能的重建，这就是治疗性克隆。但一些研究观察到，胚胎干细胞发育分化过程中具有极高的非整倍体发生率，美国马萨诸塞州耶尼德研究组的最新研究发现，克隆动物的基因在构成没有缺陷的情况下，也不能像正常动物基因一样准确表达出来，也就是说，克隆动物存在无法正确生长发育的危险。正是这个原因，造成现在98％的动物克隆实验失败，而顺利降生的克隆动物也经常出现体重超重等异常。研究还发现，利用目前的克隆技术取患者体细胞核的细胞克隆培育出来的新组织一样会存在缺陷，这项技术还有待完善、成熟。体细胞克隆所需的卵细胞难以获得，成体干细胞则可从患者自身获得，而不存在组织相容性的问题，治疗时可避免长期应用免疫抑制剂对患者的伤害。此外，少量的骨髓切除治疗有助于形成部分造血嵌合，可使异体成体干细胞的治疗成为可能。 2、 虽然胚胎干细胞能分化成各种细胞类型，但这种分化是“非定位性”的。目前尚不能控制胚胎干细胞在特定的部位分化成相应的细胞，当前的做法容易导致畸胎瘤。在应用胚胎干细胞治疗前，必须先进行初步的细胞诱导分化，以防止畸胎瘤的发生。应用胚胎干细胞时，也必须确认胚胎干细胞供者没有诸如（肌）营养失调症之类的遗传性疾病。相对而言，成体干细胞不存在上述问题，例如骨髓移植实验并不引发畸胎瘤。 3、 成体干细胞也具有类胚胎干细胞的高度分化能力。我室在国内率先提出了成体干细胞可塑性及中胚层来源成体干细胞分化机制研究，已在国家卫生部立项，并获得国家科技攀登计划、国家自然科学基金、纽约CMB基金、卫生部专项基金、天津市科委重大科技攻关“干细胞组织工程”项目和中美合作项目等大力支持。现已建立了干细胞平台技术，从肌肉、肝脏、骨髓中成功地发现和分离了成体干细胞群，完成了干细胞定向诱导分化成骨、软骨、神经细胞、心肌细胞和血管内皮细胞的研究；最近又研究发现，从胰腺等组织可分离出间充质表型的成体干细胞群，具有多系分化潜能国内外尚未见相关报道。另外，我室率先在体内和体外实验证实，间充质表型干细胞群可在干细胞调控因子诱导下转化成造血干细胞，在本次大会上多家著名实验室也重复出同样结果。在上述研究工作的基础上，我们又提出了成体干细胞研究的新假说，即在人体发育的过程中，成体干细胞是存留在多种组织中、具有多系分化能力的亚全能干细胞群体，这些细胞都具有相同或相似的细胞表型，在适合的微环境下可分化成多种组织细胞。成体干细胞移植是治疗血液系统疾病、先天性遗传疾病以及多发性和转移性恶性肿瘤疾病的最有效方法。 但胚胎干细胞也存在自身的优势： 1、 胚胎干细胞能永生化，可以传代建系，且增殖能力强，来源充沛。 2、 虽然成体干细胞具有向多系分化的能力，但这种分化的“效率”尚不理想。通过体外的扩增培养能提高转化效率，但是体外的转化是否会引起成体干细胞遗传变化还有待证实，而且这种分化是否是成体干细胞多系分化的结果尚无法肯定。即使是成体干细胞多系分化的结果，我们也不明了是何种信号诱导了整个过程的发生。而胚胎干细胞的研究已经有三十多年的历史。鼠胚胎干细胞的研究已经证明了胚胎干细胞的全能性。相应的信号诱导机制的研究也取得了长足的进展。目前鼠胚胎干细胞的研究成果给正在进行的人体胚胎干细胞研究很大的助力。 成体干细胞和胚胎干细胞各有自身的优势和缺陷。对于一个实验室而言，同时开展对两者的研究，不仅是可能的，而且能互为裨益，相得益彰。两者的研究对干细胞领域而言都是必要的。 今年3月在纽约即将召开基础科学研讨大会，“组织细胞工程”有四大主题，其中三个是围绕干细胞资源、细胞间相互作用、细胞生长微环境展开的。2003年胚胎干细胞和成体干细胞在美国医学生物研究领域都将单独立项。由此看出，随着干细胞研究的不断深入和发展，目前一些疑难病症将可能得到治愈。 上一篇：胚胎干细胞独特的分化控制机制 下一篇：体细胞、胚胎干细胞和成体干细胞
Extensive campaign helps Saudi Arabia to attract 10,000 stem cell donors Saudi Arabia is the first country in the Arab world to record more than 10,000 stem cell donors, a medical feat that will encourage people to donate stem cells and promote stem cell therapy in the kingdom to help Read more
A randomized, double-blinded, single-center, phase 2 efficacy, and safety study of allogeneic HB-adMSCs for the treatment of patients with Chronic Post-COVID-19 SyndromeSummaryThis is an FDA clinical study to evaluate the safety and efficacy of multiple intravenous administrations of allogenic HB-adMSCs for the treatment of Chronic Post-COVID-19 Syndrome. This study was Read more
Scientists have created a model human embryo with a heartbeat and traces of blood in an advance that offers an extraordinary window into the first weeks of life. The synthetic structure, created from human stem cells without the need for eggs, sperm or fertilisation, replicated some of the cells and Read more
Mortality due to end-stage liver disease ranks as the 12th leading cause of death in the United States. Liver transplantation remains the primary treatment for this condition, but a severe shortage of organ donors highlights the urgent need for alternative therapeutic approaches. Stem Cell Therapy Using mRNA TechnologyThe study, published Read more
clínica de células madre Aresse: L’extension, 08025 Barcelone WhatsApp: +447778936902 , +33745637397, +34670491885 Les cellules souches ont déjà été utilisées dans: Reconstruction mammaire après mastectomie partielle ou tumorectomie. Également en combinaison avec le lipotransfert pour l’augmentation mammaire Régénération tissulaire après nécrose d’irradiation Réparation du calvaire après une blessure Guérison de la fistule: trachéale (nécrose Read more
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Advances in Anti-Aging and Longevity Stem Cell Therapy in 2024 The quest for extended youth and longevity has captivated humanity for centuries. In recent years, scientific advancements have brought us closer to realizing these aspirations, particularly through the potential of stem cell therapy. By harnessing the regenerative capabilities of stem Read more
Stem Cell Therapy for Erectile Dysfunction in 2024: An Informed and Optimistic Outlook Based on the Latest Scientific Data Erectile dysfunction (ED) is a prevalent health issue affecting millions of men worldwide, significantly impacting their quality of life and psychological well-being. As of 2024, stem cell therapy emerges as an Read more
Kuwait – Al-Sabah Family Arabic: English: 2. Qatar – Al-Thani Family Arabic: English: 3. Saudi Arabia – Al-Saud Family Arabic: English: 4. UAE – Al Nahyan and Al Maktoum Families Arabic: English:
Stem Cell-Based Treatments for Type 1 Diabetes: Regenerating the Pancreas and Restoring Metabolic Balance Type 1 diabetes is a chronic autoimmune condition where the body’s immune system attacks insulin-producing beta cells in the pancreas. This leads to elevated blood glucose levels and metabolic imbalances. Left untreated or poorly managed, it Read more
Embark on a journey into the world of stem cells, the building blocks of life. Explore their remarkable potential for cellular regeneration and the exciting advancements unlocking their therapeutic applications.
Mesenchymal stem cells (MSCs) hold immense therapeutic potential due to their self-renewal capacity, multipotent differentiation, and paracrine effects. Their applications span regenerative medicine, tissue engineering, and immune modulation, offering promising avenues for treating various diseases and injuries.
Stem cells hold immense potential in revolutionizing the treatment of neurodegenerative diseases like ALS and Parkinson’s. By harnessing their ability to differentiate into neural cells and secrete neurotrophic factors, stem cells offer a promising avenue for neuroprotection, regeneration, and functional recovery.
Autologous and allogeneic stem cell transplants offer distinct advantages and challenges in treating various medical conditions. This analytical article compares their outcomes, addressing patient selection criteria, transplant-related complications, and long-term survival rates. Understanding these differences is crucial for healthcare professionals and patients considering stem cell transplantation.
iPSCs offer unprecedented opportunities for modeling neurodegenerative diseases, providing insights into disease mechanisms and potential therapeutic targets. However, limitations such as genetic variability, disease heterogeneity, and scalability hinder their full potential.
**Stem Cell Isolation and Expansion: Novel Strategies**
Emerging approaches for isolating and expanding stem cell populations are revolutionizing regenerative medicine. This article explores innovative techniques that enhance stem cell purity, yield, and functionality, paving the way for advancements in tissue repair, disease modeling, and personalized therapies.
**Overcoming Immunological Barriers in Stem Cell Transplantation**
Immunological barriers pose significant challenges in stem cell transplantation. Understanding the mechanisms underlying these barriers is crucial for developing effective strategies to prevent graft rejection and improve transplant outcomes. This article analyzes the latest advancements in overcoming immunological barriers, including immunosuppressive therapies, gene editing, and immune tolerance induction.
Japan’s advancements in stem cell therapy, particularly iPS cells, have revolutionized the field of regenerative medicine. This article delves into the scientific breakthroughs, clinical applications, and ethical considerations surrounding iPS cells, offering insights into their transformative potential and the future of stem cell research.
South Africa’s stem cell research endeavors are poised to revolutionize healthcare, particularly in addressing health disparities. By harnessing the potential of regenerative medicine, researchers aim to tackle prevalent diseases and improve access to advanced treatments, fostering a more equitable healthcare system.
Finland is emerging as a hub for stem cell research, particularly in the realm of neurodegenerative diseases. With cutting-edge facilities and a collaborative research environment, Finnish scientists are leveraging stem cells to unravel disease mechanisms and develop novel therapies. This excerpt highlights the innovative approaches and promising advancements made in Finland, positioning the country as a leader in the fight against neurodegenerative disorders.
Romania’s stem cell research landscape is gaining momentum, with clinical trials underway exploring the therapeutic potential of stem cells in cardiovascular medicine. These trials aim to harness the regenerative properties of stem cells to repair damaged heart tissue and improve cardiac function. This article analyzes the current state of stem cell innovations in Romania, highlighting the promising clinical applications and the need for continued research to advance the field.
Estonia’s burgeoning stem cell research landscape is revolutionizing regenerative ophthalmology, with groundbreaking advancements in corneal regeneration and retinal repair. This article explores the latest innovations, highlighting the potential of stem cells to restore vision and improve eye health.