Stem Cells therapy

The patients with decompensated cirrhosis mostly have to opt for liver transplantation, but the limited availability of donor organs and high cost results in high waitlist mortality . Stem cells of one’s own body help in liver regeneration and delay or possibly avoid liver transplant. Total blood count increases many Read more…

Liver stem cells that express high levels of telomerase, a protein often associated with resistance to aging, act in mice to regenerate the organ during normal cellular turnover or tissue damage, according to a study by researchers at the Stanford University School of Medicine. The cells are distributed throughout the Read more…

Stem Cell Therapy and mRNA Technology: A Powerful DuoThe primary goal of this treatment is to regress diseased liver tissue, reducing the need for liver transplants significantly. The therapy activates stem cells within the liver to generate healthy hepatocytes (liver cells), offering a potential alternative treatment for severe acetaminophen intoxication Read more…

People are having children later than ever before. The average age of new parents in the United States has been rising for at least the past half century. But time is tough on our bodies and our reproductive systems. For instance, as animals age, our stem cells are less effective Read more…

Subsequently, the researchers reprogrammed the disease-causing gene defects in the stem cells using the CRISPR-Cas9 technique, known as gene scissors. Finally, the researchers guided the corrected stem cells to differentiate into liver cells to see whether the disease that impairs hepatic function was actually cured and that the fixed cells Read more…

Researchers can use the light naturally thrown off by biological specimens to better study the different states of stem cells in the nervous system When cells shift from active to quiescent states, the presence and abundance of certain proteins important to metabolism change. These molecules alter the way light is Read more…

In many pulmonary diseases, insufficient stem cells allow damage to progress, but researchers have developed a lung-targeted, drug-like small molecule to stimulate the growth of lung stem cells, according to data published in the Proceedings of the National Academy of Sciences. The researchers identified dipeptidyl peptidase 4 (DPP4) inhibitors as Read more…

In the journal Nature Cell Biology, the researchers describe what happened when they transplanted liver stem cells into mice with severely damaged livers. Over the ensuing months, the cells spurred major areas of the liver to regrow, improving the structure and function of the animals’ organs. The liver is generally Read more…

Mortality due to end-stage liver disease ranks as the 12th leading cause of death in the United States. Liver transplantation remains the primary treatment for this condition, but a severe shortage of organ donors highlights the urgent need for alternative therapeutic approaches. Stem Cell Therapy Using mRNA TechnologyThe study, published Read more…

Cell Therapy ProductsAlofiselTIGENIXAn allogeneic stem cell therapy to treat complex perianal fistulas in patients with Crohn’s disease. Received EU marketing authorisation in March 2018. CartistemMEDIPOSTA cellular therapeutic agent containing allogeneic human umbilical cord blood-derived mesenchymal stem cells, indicated for the treatment of knee cartilage defects such as traumatic articular cartilage, Read more…

Que Sont Les Cellules Souches ? Et Quelle Est L’utilité Des Cellules Souches Dans Les Traitements Invasifs Et Non Invasifs ?Les organes et les tissus du corps humain sont constitués de cellules. Quelques de ces les cellules s’auto-renouvellent et se transformer en différents types de cellules. Ces cellules sont appelées Read more…

Cord Blood TherapiesCLEVECORD (HPC Cord Blood)CLEVELAND CORD BLOOD CENTERApproved by the U.S. FDA in 2016 for use in unrelated donor hematopoietic progenitor cell transplantation procedures. HPC Cord BloodBLOODWORKSApproved by the U.S. FDA in 2016 for use in unrelated donor hematopoietic progenitor cell transplantation procedures. HPC Cord BloodMD ANDERSON CORD BLOOD Read more…

Limb girdle muscular dystrophy (LGMD), a group of progressive degenerative disorders, causes functional limitation affecting the quality of life. Cell therapy is being widely explored and preliminary studies have shown beneficial effects. Cell therapy induces trophic-factors release, angiogenesis, anti-inflammation, and protein synthesis, which helps in the reparative process at the microcellular level. In this Read more…

Tissue-Engineered ProductsAurixNUO THERAPEUTICSA biodynamic hematogel composed of platelet-rich plasma gel prepared from a small sample of a patient’s own platelets and plasma as a catalyst for healing indicated for the treatment of wounds. Marketed in the U.S. under Section 361 for the Platelet Rich Plasma and under 510(k) clearance as Read more…

Bone would completely encapsulate the stem cells, providing a shield from all angles. There might also be other benefits to a niche in the bone marrow, such as lower oxygen levels, which could provide protection from other forms of DNA damage.

Cell-Based Immunotherapy ProductsAbecmaBLUEBIRD BIOA chimeric antigen receptor (CAR) T-cell therapy for adults with relapsed or refractory multiple myeloma. Approved by the US FDA in March 2021. Approved by Health Canada in May 2021. Approved by the EMA in August 2021. Approved for use in Japan in February 2022. APCedenAPAC BIOTECHAPCeden Read more…

Adult stem cells reside in niches that maintain, regulate and protect them. Fresh light has now been shed on how the need for protection has driven changes in the locations of these niches during evolution. Tissue-specific stem cells have the crucial role of maintaining and replenishing all the specialized cells Read more…

Gene Therapy ProductsCollategeneANGESA gene therapy consisting of an intramuscular injection of plasmid (DNA) coding for Hepatocyte Growth Factor (HGF), intended to grow blood vessels, for the treatment of critical limb ischemia. Approved in Japan in February 2019. GendicineSHENZHEN SIBIONO GENETECHA recombinant adenovirus engineered to express wildtype-p53 (rAd-p53), designed to treat Read more…

Clinical trials – Stem cells and Autism Type of trial Number and type of cells transplanted/source Duration Primary outcomes Reference Autologous, open-label 8.19 × 107 mononuclear cells/bone marrow 26 months Safety Improvements in cognitive and social tasks Improvement in hypoperfused brain areas 88 Allogenic, nonrandomized, open-label, single-center Phase I/II trial, combined Read more…