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Stem cell therapy clinical trials https://clinicaltrials.gov/ct2/results?cond=&term=stem+cells&type=&rslt=&recrs=a&recrs=d&age_v=&gndr=&intr=&titles=&outc=&spons=&lead=&id=&cntry=&state=&city=&dist=&locn=&rsub=&strd_s=&strd_e=&prcd_s=&prcd_e=&sfpd_s=&sfpd_e=&rfpd_s=&rfpd_e=&lupd_s=&lupd_e=&sort=

Scientists have created a model human embryo with a heartbeat and traces of blood in an advance that offers an extraordinary window into the first weeks of life. The synthetic structure, created from human stem cells without the need for eggs, sperm or fertilisation, replicated some of the cells and Read more

العلاج بالخلايا الجذعية في أوروبا والولايات المتحدة الأمريكية

Health news 2024 What is inflammation?Generally speaking, the term inflammation refers to all activities of the immune system that occur where the body is trying to fight off potential or real infections, clear toxic molecules or recover from physical injury. There are five classic physical signs of acute inflammation: heat, Read more

Liste des étudiants et des internes de médecine, classés par ordre de mérite,ayant satisfait aux épreuves classantes nationales anonymes donnant accèsau troisième cycle des études médicales, organisées au titre de l’annéeuniversitaire 2013-2014.Nota : Il est demandé aux étudiants de vérifier les informations les concernant et de les corrigerdirectement dans l’application Read more

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Tissue regeneration after irradiation necrosis Calvarial repair after injury Fistula healing:  tracheal (tissue necrosis), perianal and Crohn’s disease Acute GVHD after bone marrow transplantation Facial and skin rejuvenation and other cosmetic corrections of the skin that are arose from aging and sun exposure Multiple Sclerosis Hemorrhagic or ischemic stroke Spinal Read more

Modern clinic located in one of the prestigious areas of Barcelona in Spain. One of the activities of the clinic is regenerative medicine, which includes various types of cell therapy. Clinic and Laboratory offers patients such innovative treatments as: stem cell therapy, T-cell therapy, induced pluripotent cell therapy (iPSCs), the Read more

Martinique , 2024 WhatsApp:  +447778936902 , +33745637397,+34670491885 [email protected] Lo que aprenderás Conceptos clave de las células madreCultivo de células madreFuentes de células madreMecanismos de división celularOrganización espacial de las células madreHistoria de las células madreAplicaciones de las células madreEpigenéticaPapel de la epigenéticaTerapia con células madreTerapia de reemplazo celularTrabajo de las células madre Read more

Stem cell therapy and Parkinson’s disease. The blood-brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that prevents many substances, including most large molecules and cells, from crossing from the bloodstream into the brain tissue. This barrier is essential for protecting the brain from toxins and pathogens Read more

Stem Cell Therapy for Parkinson’s DiseaseStem cell therapy for Parkinson’s disease is a treatment approach that involves using stem cells, which are undifferentiated cells that can develop into various types of specialized cells, to replace or repair damaged or lost cells in the brain associated with Parkinson’s disease. The stem Read more

address: L’Eixample, 08025 Barcelona, Spain contact:  [email protected]   WhatsApp: +447778936902 , +34670491885 Face Stem Cells injections What is rejuvenation with the help of stem cells?Anti-age skin treatments using stem cells is a cosmetic procedure that involves the use of stem cells to restore and revitalize the natural functions of the skin. Stem cells are Read more

Dr. Eugene Zadorin – Member of the World Spa Organization Scientific Committee.

LA CLINIQUE DE PARIS La Clinique de Paris, founded by renowned specialist Dr. Claude Chauchard, is a well-established European clinic. Claude Chauchard, La Clinique de Paris International, was brought to Taipei in 1993, where Dr. Chauchard introduced the anti-ageing concept More than a decade later, Claude Chauchard has expanded throughout Read more

Orthopedic stem cell therapy clinic, France Here are some of the stem cell therapy treatments : Platelet Rich Plasma Therapy (PRP) – joints, spinePlatelet Rich Plasma Therapy is a ground-breaking treatment that uses proteins known as growth factors. Growth factors are naturally occurring substances that enhance the healing process of Read more

European Clinical Trials Information Network The European Clinical Trials Information Network revolutionizes how patients across Europe access clinical trial information. By eliminating language barriers, our platform ensures that everyone, regardless of their native language, can find relevant and understandable trial data. This breakthrough service connects patients with pioneering treatments, fostering Read more

Mortality due to end-stage liver disease ranks as the 12th leading cause of death in the United States. Liver transplantation remains the primary treatment for this condition, but a severe shortage of organ donors highlights the urgent need for alternative therapeutic approaches. Stem Cell Therapy Using mRNA TechnologyThe study, published Read more

In the journal Nature Cell Biology, the researchers describe what happened when they transplanted liver stem cells into mice with severely damaged livers. Over the ensuing months, the cells spurred major areas of the liver to regrow, improving the structure and function of the animals’ organs. The liver is generally Read more

In many pulmonary diseases, insufficient stem cells allow damage to progress, but researchers have developed a lung-targeted, drug-like small molecule to stimulate the growth of lung stem cells, according to data published in the Proceedings of the National Academy of Sciences. The researchers identified dipeptidyl peptidase 4 (DPP4) inhibitors as Read more

Researchers can use the light naturally thrown off by biological specimens to better study the different states of stem cells in the nervous system When cells shift from active to quiescent states, the presence and abundance of certain proteins important to metabolism change. These molecules alter the way light is Read more

Subsequently, the researchers reprogrammed the disease-causing gene defects in the stem cells using the CRISPR-Cas9 technique, known as gene scissors. Finally, the researchers guided the corrected stem cells to differentiate into liver cells to see whether the disease that impairs hepatic function was actually cured and that the fixed cells Read more

People are having children later than ever before. The average age of new parents in the United States has been rising for at least the past half century. But time is tough on our bodies and our reproductive systems. For instance, as animals age, our stem cells are less effective Read more

Stem Cell Therapy and mRNA Technology: A Powerful DuoThe primary goal of this treatment is to regress diseased liver tissue, reducing the need for liver transplants significantly. The therapy activates stem cells within the liver to generate healthy hepatocytes (liver cells), offering a potential alternative treatment for severe acetaminophen intoxication Read more

Liver stem cells that express high levels of telomerase, a protein often associated with resistance to aging, act in mice to regenerate the organ during normal cellular turnover or tissue damage, according to a study by researchers at the Stanford University School of Medicine. The cells are distributed throughout the Read more

The patients with decompensated cirrhosis mostly have to opt for liver transplantation, but the limited availability of donor organs and high cost results in high waitlist mortality . Stem cells of one’s own body help in liver regeneration and delay or possibly avoid liver transplant. Total blood count increases many Read more

Bangkok, Thailand WhatsApp: +447778936902      e-mail: [email protected] MISSION STATEMENT “To provide customers with the safest, most effective, up to date treatment delivered in a friendly environment while at the same time ensuring each customer receives the highest level of personal service and attention.” COA authenticityEvery case will receive a certification of Read more

  WhatsApp: +447778936902 , +33745637397, +34670491885 年龄相关性黄斑变性：RPE细胞 在我们的眼睛中，存在着一种视网膜色素上皮细胞，而在年龄相关性黄斑变性（Age-related macular degeneration，AMD）中，视网膜色素上皮细胞将逐渐丧失功能，并导致黄斑中的光感受器死亡，影响视力甚至最终形成失明。如果早期发现疾病，可以通过抗血管内皮生长因子（anti-VEGF）药物治疗。 日本理化所Masayo Takahashi（也就是高桥政黛）研究组正在研究移植湿性AMD患者iPSC分化的视网膜色素上皮（iPS-RPE）细胞薄片的可行性。采集两例AMD晚期患者的皮肤成纤维细胞，制备成iPS-RPE细胞。在这两例患者中，其中1例患者接受了自体iPS-RPE细胞薄片移植手术。术后1年，移植的RPE细胞薄片证实移植成功，视力得到维持。 随后的临床研究，同样是这个研究团队，将从 HLA-homo iPS 细胞库中制备的RPE细胞移植到与HLA匹配的湿性AMD患者中。局部使用类固醇，没有使用免疫抑制剂。在全部5例接受移植的病例中，经过1年的观察期，证实了移植细胞的存活，并且没有异常生长。在临床试验中，观察到的不良事件包括轻度炎症、疑似轻度排斥反应、视网膜水肿、角膜上皮脱离和无菌性眼内炎。中期结果表明，经过1年的随访，HLA匹配的异体iPS-RPE细胞移植是安全的，并且稳定存活。 -02- 角膜缘干细胞缺乏症：角膜片角膜之所以维持透明，它表面的上皮细胞功不可没。我们人类的角膜上皮细胞不断生长，不断更新，而维持这种更新的源泉就是角膜缘干细胞。当角膜缘干细胞缺乏时（即角膜缘干细胞缺乏症，limbal stem cell deficiency，LSCD），会导致角膜上皮持续性缺损，角膜血管化、角膜溃疡感染、不透明，严重者造成角膜穿孔、甚至危及整个眼球，导致失明。供体角膜移植已被用于治疗可能导致失明的严重角膜上皮疾病，但也存在排斥反应和供体短缺的问题。 日本大阪大学的眼科医师 Koji Nishida（西田幸二）团队利用iPSC来源的角膜细胞组织层来修复损伤的角膜。研究小组开发了一种二维培养系统“SEAM方法”，通过促进iPS细胞自分化来组织重建所有的眼样结构。这个细胞薄片构成眼睛的主要细胞群（包含角膜上皮、视网膜和晶状体上皮）出现在组织的特定区域。研究小组从二维组织结构中分离出了角膜上皮祖细胞，并成功地产生了功能性的角膜上皮组织。 iPSC细胞疗法在日本的临床研究 iPSC治疗角膜缘缺乏症示意图 研究小组通过将人类iPSC制备的角膜上皮组织移植到动物模型中，证明了治疗效果。在2019年7月至2020年12月，这个研究小组把用iPSC制作的厚度0.05毫米薄膜状角膜组织，移植给几乎丧失视力的“角膜缘干细胞缺乏症”的4名患者的全球首例临床研究已完成。 此后经过1年的随访观察，未发生排异反应和癌变等问题，确认了安全性。全部患者症状均有改善，其中3人的矫正视力提高，有患者从0.15升至0.7。 -03- 帕金森病：多巴胺神经祖细胞大多数哺乳动物，大脑在胚胎时期就已经完成大部分，只有一小部分神经在出生后持续发展。神经损伤引起的疾病将导致永久性的残疾，如何利用iPSC来修复神经系统是目前干细胞疗法的热门研究。 人们发现利用iPSC分化的多巴胺能神经元可以治疗帕金森病。帕金森病是大脑黑质区（subatantia nigra）分泌多巴胺的神经细胞退化造成的一种疾病。帕金森病仅次于阿尔茨海默病，是第二常见的神经退行性疾病。在美国，男性的终生风险为2%，女性为1.3%。 iPSC细胞疗法在日本的临床研究iPSC治疗帕金森示意图日本京都大学iPS细胞研究所JunTakahashi（高桥淳，也就是高桥政黛的丈夫）研究小组于2018年8月开展使用iPSC来源的多巴胺神经祖细胞治疗帕金森病的临床试验。临床试验移植的细胞来自HLA-homo iPS 细胞库。种子细胞iPSC经过诱导分化，并通过流式细胞仪分选纯化出corin阳性的细胞（corin是多巴胺神经祖细胞的细胞表面标记物）。研究小组将与HLA匹配后的异体iPSC诱导分化为多巴胺神经祖细胞，配合低量免疫抑制剂，通过定位脑手术将大约500万个分化的细胞移植到患者大脑纹状体左右两侧皮质部分。 在临床试验之前，先证实了移植的人类iPSC来源的多巴胺神经祖细胞在帕金森病的食蟹猴模型中的有效性和安全性。经过两年的跟踪，没有观察到猴子肿瘤的形成，也没有发现任何恶性转化的证据，确认了安全性。结果显示：移植的猴子运动活动增加，帕金森病症状有所改善。PET分析显示，移植的细胞在大脑中合成了多巴胺。 -04- 脊髓损伤：神经祖细胞脊髓损伤（Spinal cord injury），通常指脊髓受到外部影响，造成损伤部位及其以下部分瘫痪或全部瘫痪，使患者终身残疾。脊髓损伤是一种比较常见的外伤。脊髓损伤治疗的难点在于神经传导重建及运动功能的恢复。 日本庆应大学生理学 Hideyuki Okano（岡野荣之）研究小组于2019年2月被批准开展使用采用iPSC来源神经祖细胞治疗亚急性期脊髓损伤的临床研究。但由于COVID-19疫情原因，研究被延后至2021年年底才得以开展。临床试验移植的细胞来自HLA-homo iPS细胞库。临床试验选择的适应症，为亚急性脊髓损伤（C3/4-Th10水平，损伤后14-28天内），共纳入4名受试患者。试验的主要目的是评估hiPSC-NS/PC移植细胞和移植方法的安全性。次要目标是获得其对神经功能和生活质量影响的初步证据。 iPSC细胞疗法在日本的临床研究iPSC治疗脊髓损伤的临床概要 细胞来源：试验使用的细胞来源是iPSC-神经祖细胞。 细胞处理：在预定的移植手术前4天，细胞将进行解冻复苏，经过培养和洗涤处理后，200万个细胞重悬在20μL的人工脑脊液中，保持在4°C环境，直到移植。移植方式：移植中患者接受全麻，通过术前MRI和术中超声辅助，细胞在手术显微镜下通过神经注射器移植到损伤部位的中心。 -05- 心力衰竭：心肌薄片心力衰竭（heart failure）简称心衰，是由于心脏泵血力量不足导致的一种心脏疾病。缺血性心脏病是由于冠状动脉阻塞引起心肌组织慢性缺血，从而导致功能性心肌细胞坏死。然而，成熟的心肌细胞是不能自我更新的，缺血和坏死区域的心肌逐渐被纤维组织所取代。因此，补充功能性心肌细胞是延缓心衰进程的一种合理方法。因为心肌细胞没有增殖能力，难以大量产生。因此，骨骼肌细胞、骨髓单个核细胞和间充质干细胞（MSCs）都是候选细胞，被用于替代心肌细胞，并进行了动物实验和临床试验。 起初，细胞片由自体骨骼肌细胞制造的，可以直接贴到心脏表面。治疗机制主要依靠细胞片旁分泌的营养因子和细胞片细胞与宿主心肌融合。然而，因为是自体个性化移植，缺点很明显：一是患者需要等待时间长，二是制作成本较高。因此，开发一种通用型标准化现货性产品，尤为重要。细胞薄片，便是这样一种产品，通过HLA配型后的iPSC衍生的心肌细胞薄片，可当做通用型产品。 在动物实验中，研究发现人类胚胎干细胞衍生的心肌细胞在组织学上和电生理学上都能与宿主心肌匹配结合，这与以前移植的非心肌细胞不同。在猴子实验，也显示了其生存能力和功能的改善。在猴子心肌梗死模型中，HLA匹配的猴子iPSC来源的心肌细胞即使在移植后12周仍能存活，并产生宿主心脏的功能改善。然而，在所有的猴子中都观察到一些室性心律失常，这表明处理移植前的心律失常的影响是必要的。 iPSC细胞疗法在日本的临床研究在日本，HEARTSHEET® Read more

Tokyo, Japan Medical institutions that provide regenerative medicine using stem cellscreate a regenerative medicine provision plan for each regenerative medicine technology they implement, and have it reviewed for safety, effectiveness, etc.by a specified certified regenerative medicine committee approved by the Ministry of Health, Labor and Welfare receive. 幹細胞を用いる再生医療等を提供する医療機関は、実施する再生医療技術ごとに再生医療等提供計画を作成し、厚生労働省が認可した特定認定再生医療等委員会によって安全性、有効性等について審査を受けます。 Aging care Read more

United States and Monterrey, Mexico Gene therapy, which involves modifying or manipulating genes to treat or prevent disease, has shown promising results in various areas of medicine. Since August 2017, the U.S. Food and Drug Administration has approved three gene therapy products, the first of their kind. Aging is one Read more