Stem cells therapy for Huntington’s disease.
Huntington’s disease (HD) is a genetically heritable disease that destroys ‘medium spiny neurons’ (MSNs) in the brain, leading to emotional changes, mental decline and impaired movement.
The clinical triad of HD includes chorea, psychiatric/behavioral disturbances and cognitive decline.
Beneficial effects of stem cells therapy
have been reported for transplantation of stem cells derived
from non-neural tissue, for example, mesenchymal- and adipose-derived stem cells, which have mainly been attributed to their secretion of growth and neurotrophic factors.
iPSCs and embryonic stem cells may be able to make large numbers of neural stem cells.
People with the degenerative disorder Huntington’s disease could receive treatment with stem cells
to slow development of symptoms.
Mesenchymal stem cells (MSC) have been shown to have significant effects on restoring synaptic connections between
damaged neurons, promoting neurite outgrowth, secreting anti-apoptotic factors in the brain, and regulating inflammation.
Many trials have assessed the safety and efficacy of human MSC delivery to neuronal tissues via systemic IV infusion.
Information Notice:
The information on this page is intended for scientific, educational, and general informational purposes. Clinical approaches, availability, and regulatory status may vary by country, institution, and medical indication. For individual medical decisions, readers should consult qualified healthcare professionals and accredited medical centers.
The information on this page is intended for scientific, educational, and general informational purposes. Clinical approaches, availability, and regulatory status may vary by country, institution, and medical indication. For individual medical decisions, readers should consult qualified healthcare professionals and accredited medical centers.
Editorial Note:
This article has been prepared by the NBScience editorial team within the scope of clinical research, biotechnology, and international medical information.
This article has been prepared by the NBScience editorial team within the scope of clinical research, biotechnology, and international medical information.
