- CNS Cogntive Enhancement Gene Therapy and Dual Gene Therapy – Follistatin and Telomerase Gene Therapy
2) Dementia Intranasal Gene Therapy
Klotho Links To Articles
The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease
https://www.hindawi.com/journals/ijhy/2012/757469/
Klotho at the Edge of Alzheimer’s Disease and Senile Depression
https://www.ncbi.nlm.nih.gov/pubmed/29978424
Is Klotho the Key to Treating Alzheimer’s and Other Diseases of Aging?
https://www.biospace.com/article/is-klotho-the-key-to-treating-alzheimer-s-and-other-diseases-of-aging-/
One Day There May Be a Drug to Turbocharge the Brain.
https://www.nytimes.com/2019/04/02/health/klotho-brain-enhancement-dementia-alzheimers.html
Follistatin Links to Articles
“Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy Patricio V. Sepulveda https://www.nature.com/articles/srep17535 WEB 2015
Abellan van Kan, G. “Epidemiology and consequences of sarcopenia.” The journal of nutrition, health & aging 13.8 (2009): 708-712.
Amthor, Helge, et al. “Lack of myostatin results in excessive muscle growth but impaired force generation.” Proceedings of the National Academy of Sciences 104.6 (2007): 1835-1840.
Amthor, Helge, and Willem MH Hoogaars. “Interference with myostatin/ActRIIB signaling as a therapeutic strategy for Duchenne muscular dystrophy.” Current gene therapy 12.3 (2012): 245-259.
Anker SD, Negassa A, Coats AJ, et al. Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study. Lancet 2003;361:1077–83.
Argiles JM, Anker SD, Evans WJ, et al. Consensus on cachexia definitions. J Am Med Dir Assoc 2010;11:229–30
Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF. Myostatin
promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting
their differentiation into myofibroblasts. J Endocrinol 2008;196:235–49
Barns, Mitchell, et al. “Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice.” The international journal of biochemistry & cell biology 53 (2014): 174-185.
Bartke, Andrzej. “Growth hormone and aging: a challenging controversy.” Clin Interv Aging 3.4 (2008): 659-665.
Becker, Clemens, et al. “Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial.” The lancet Diabetes & endocrinology 3.12 (2015): 948-957.
Benny Klimek ME, Aydogdu T, Link MJ, Pons M, Koniaris LG, Zimmers TA. Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. Biochem Biophys Res Commun. 2010;391:1548–54.
Berardi, Emanuele, et al. “Molecular and cell-based therapies for muscle degenerations: a road under construction.” Frontiers in physiology 5 (2014): 119.
