stem cells therapies

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation   Highlights •NSCs from somatic tissues or direct reprogramming equally repress neuroinflammation •Extracellular succinate activates SUCNR1/GPR91 on NSCs •Activated NSCs secrete PGE2 and scavenge succinate, thus reprogramming type 1 MPs •Sucnr1 mutant NSCs have reduced anti-inflammatory activity after transplantation Read more…