Terapia con cellule staminali & Ricerca clinica
Traduzione clinica di terapie sperimentali con cellule staminali neurali
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation Highlights •NSCs from somatic tissues or direct reprogramming equally repress neuroinflammation •Extracellular succinate activates SUCNR1/GPR91 on NSCs •Activated NSCs secrete PGE2 and scavenge succinate, quindi riprogrammare il tipo 1 MPs •Sucnr1 mutant NSCs have reduced anti-inflammatory activity after transplantation Per saperne di più
