Terapia con cellule staminali dell'epilessia .
L'epilessia come uno dei disturbi neurologici più comuni colpisce più di 50 milioni di persone in tutto il mondo con un tasso di prevalenza più elevato nei paesi a basso reddito. Scariche elettriche eccessive nei neuroni in seguito al danno o alla perdita delle cellule neurali causano convulsioni ricorrenti. One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (TLE) which results from hippocampal sclerosis. Nowadays, similar to other diseases, epilepsy also is a candidate for treatment with different types of stem cells.
Various stem cell types were used for treatment of epilepsy in basic and experimental researches.
Two Stem cell therapy has been shown efficacious in treating experimental models of neurological disorders, including Parkinson’s disease, and neuropsychiatric diseases, such as depression
Major roles of stem cell therapy in epilepsy are prophylaxis against chronic epilepsy and amelioration cognitive function after the occurrence of TLE.
Cellule staminali pluripotenti indotte (iPSC)
Some epilepsies are caused because of a genetic mutation or change in neurons. Per esempio, Dravet syndrome is a devastating form of childhood epilepsy caused by a mutation in a specific sodium channel.
Scientists have found a way to take stem cells from people with Dravet syndrome and program them to become any type of cell in the body. These new cell types are called cellule staminali pluripotenti. These new cells can be made into neurons.
Although much more research needs to be done, stem cell therapy is an attractive and promising treatment for epilepsy.
Dettagli: [email protected]
Interessato a sapere se i programmi clinici attuali, sviluppi della ricerca, o gli approcci terapeutici emergenti potrebbero essere rilevanti per la tua situazione?
Solo informazioni didattiche e di ricerca. Le decisioni mediche individuali dovrebbero essere prese consultandosi con operatori sanitari qualificati.
