干细胞治疗 and Parkinson’s disease.
血脑屏障 (血脑屏障) 是内皮细胞的高度选择性半透性边界，可阻止许多物质, 包括大多数大分子和细胞, 从血流进入脑组织. This barrier is essential for protecting the brain from toxins and pathogens but can also hinder the delivery of therapeutic agents, 包括干细胞, to the brain.
Stem cells can potentially pass through the blood-brain barrier under certain conditions or with the use of specific delivery methods. Various strategies are being investigated to facilitate stem cell delivery to the brain. Also certain drugs or peptides can temporarily modulate the blood-brain barrier permeability, enabling the passage of therapeutic agents like stem cells.
干细胞, on the other hand, have been reported to bypass the BBB and successfully home to their target in the brain and initiate repair, making them a promising approach in cellular therapy, especially those related to neurodegenerative disease. This review article discusses the mechanism behind the successful homing of stem cells to the brain, their potential role as a drug delivery vehicle, and their applications in neurodegenerative diseases.
干细胞治疗 and Parkinson’s disease.
