Stem cell therapy holds promising potential for treating metabolic liver diseases, offering regenerative and immunomodulatory capabilities. Research explores the use of various stem cell types, including mesenchymal stem cells, liver progenitor cells, e cellule staminali pluripotenti indotte, to restore liver function, reduce inflammation, and promote tissue regeneration. The understanding of stem cell biology and the development of novel delivery strategies continue to advance the field, paving the way for personalized and effective treatments for metabolic liver diseases.