Maladie rénale chronique (CKD) est un problème de santé mondial majeur, affectant des millions dans le monde. Infection-induced CKD, a subset of CKD, arises from infections that damage the kidneys, leading to progressive loss of function. Despite advancements in conventional therapies, the treatment options for infection-induced CKD remain limited. Thérapie par cellules souches has emerged as a promising approach to address this unmet medical need, offering the potential to regenerate damaged kidney tissue and restore function.
Infection-Induced Chronic Kidney Disease: Un aperçu
Infection-induced CKD can result from various infections, including urinary tract infections, pyélonéphrite, and sepsis. These infections trigger an inflammatory response within the kidneys, leading to tissue damage and scarring. The progressive accumulation of scar tissue impairs kidney function, ultimately progressing to end-stage renal disease (ESRD) if left untreated.
Causes and Pathogenesis of Infection-Induced CKD
Urinary tract infections (UTIs) are the most common cause of infection-induced CKD. Bacteria, such as Escherichia coli, ascend the urethra and invade the bladder, causing inflammation and damage to the renal parenchyma. Pyélonéphrite, an infection of the kidney itself, can also lead to CKD if left untreated. Sepsis, a severe systemic infection, can also cause kidney damage as part of its widespread inflammatory response.