Terapia con células madre para la enfermedad de Huntington.
Enfermedad de Huntington (HD) es una enfermedad genéticamente hereditaria que destruye las "neuronas medianas espinosas" (MSN) en el cerebro, conduciendo a cambios emocionales, deterioro mental y movimiento deteriorado.
The clinical triad of HD includes chorea, psychiatric/behavioral disturbances and cognitive decline.
Beneficial effects of stem cells therapy
have been reported for transplantation of stem cells derived
from non-neural tissue, por ejemplo, mesenchymal- and adipose-derived stem cells, which have mainly been attributed to their secretion of growth and neurotrophic factors.
iPSCs and embryonic stem cells may be able to make large numbers of neural stem cells.
People with the degenerative disorder Huntington’s disease could receive treatment with stem cells
to slow development of symptoms.
Células madre mesenquimales (MSC) have been shown to have significant effects on restoring synaptic connections between
damaged neurons, promoting neurite outgrowth, secreting anti-apoptotic factors in the brain, and regulating inflammation.
Many trials have assessed the safety and efficacy of human MSC delivery to neuronal tissues via systemic IV infusion.