Limb girdle muscular dystrophy (LGMD), a group of progressive degenerative disorders, causes functional limitation affecting the quality of life. Cell therapy is being widely explored and preliminary studies have shown beneficial effects. Cell therapy induces trophic-factors release, angiogenesis, anti-inflammation, and protein synthesis, which helps in the reparative process at the microcellular level. In this 5-year longitudinal study, the effect of autologous bone marrow mononuclear cells is studied on the natural course of 65 patients with LGMD. Functional Independence Measure and manual muscle testing showed statistically significant improvement, post-cell transplantation. The key finding of this study was demonstration of a plateau phase in the disease progression of the patients. No adverse events were noted. Autologous bone marrow mononuclear cells may be a novel, safe, and effective treatment approach to control the rate of progression of LGMD, thus improving the functional outcomes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337147/
Further randomized controlled trials are required.
Does terapia con células madre work for muscular dystrophy?
Recent work has shown that stem cell transplantation may not only be able to restore dystrophin function in people with muscular dystrophies, but that it might also rejuvenate the cellular environment, effectively limiting the further progression of the disease
How long does it take to see results from tratamiento con células madre?
The speed of results from tratamiento con células madre varies from patient to patient.
Some patients report feeling better in as little as a couple of days.
More typical results have our patients back to full physical activity in four to six weeks.
