Enfermedad renal crónica (ERC) es un importante problema de salud mundial, afectando a millones en todo el mundo. Infection-induced CKD, a subset of CKD, arises from infections that damage the kidneys, lo que lleva a una pérdida progresiva de la función. A pesar de los avances en las terapias convencionales, the treatment options for infection-induced CKD remain limited. La terapia con células madre ha surgido como un enfoque prometedor para abordar esta necesidad médica insatisfecha., offering the potential to regenerate damaged kidney tissue and restore function.
Enfermedad renal crónica inducida por infección: Una descripción general
Infection-induced CKD can result from various infections, including urinary tract infections, pielonefritis, and sepsis. These infections trigger an inflammatory response within the kidneys, leading to tissue damage and scarring. The progressive accumulation of scar tissue impairs kidney function, ultimately progressing to end-stage renal disease (ESRD) si no se trata.
Causes and Pathogenesis of Infection-Induced CKD
Urinary tract infections (ITU) are the most common cause of infection-induced CKD. Bacteria, such as Escherichia coli, ascend the urethra and invade the bladder, causing inflammation and damage to the renal parenchyma. Pielonefritis, an infection of the kidney itself, can also lead to CKD if left untreated. Sepsis, a severe systemic infection, can also cause kidney damage as part of its widespread inflammatory response.
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