慢性肾脏病 (慢性肾病) 是全球主要的健康问题, 影响全球数百万人. Infection-induced CKD, a subset of CKD, arises from infections that damage the kidneys, leading to progressive loss of function. Despite advancements in conventional therapies, the treatment options for infection-induced CKD remain limited. 干细胞治疗 已成为解决这一未满足的医疗需求的有前途的方法, offering the potential to regenerate damaged kidney tissue and restore function.
Infection-Induced Chronic Kidney Disease: 概述
Infection-induced CKD can result from various infections, including urinary tract infections, 肾盂肾炎, and sepsis. These infections trigger an inflammatory response within the kidneys, leading to tissue damage and scarring. The progressive accumulation of scar tissue impairs kidney function, ultimately progressing to end-stage renal disease (终末期肾病) 如果不及时治疗.
Causes and Pathogenesis of Infection-Induced CKD
Urinary tract infections (UTIs) are the most common cause of infection-induced CKD. Bacteria, such as Escherichia coli, ascend the urethra and invade the bladder, causing inflammation and damage to the renal parenchyma. 肾盂肾炎, an infection of the kidney itself, can also lead to CKD if left untreated. 败血症, a severe systemic infection, can also cause kidney damage as part of its widespread inflammatory response.
