1. Stem Cell Therapy for Ischemic Liver Injury: Un enfoque prometedor
Ischemic liver injury, a severe condition resulting from restricted blood flow to the liver, poses a significant challenge in transplantation and surgical procedures. Terapia con células madre ha surgido como una estrategia terapéutica prometedora, Ofrece el potencial de regenerar el tejido hepático dañado y restaurar la función hepática..
2. Pathophysiology of Ischemic Liver Injury and Stem Cell Intervention
Ischemic liver injury occurs when blood flow to the liver is obstructed, leading to cellular hypoxia and oxidative stress. This triggers a cascade of events, including hepatocyte apoptosis, inflamación, and fibrosis. Células madre, with their regenerative and immunomodulatory properties, can intervene at various stages of this process, promoting tissue repair and functional recovery.
3. Types of Stem Cells Used in Ischemic Liver Injury Treatment
Various types of stem cells have been investigated for ischemic liver injury treatment, incluido:
- Células madre embrionarias (ESC): Pluripotent cells derived from the inner cell mass of blastocysts.
- Células madre pluripotentes inducidas (iPSC): Reprogrammed somatic cells that exhibit pluripotency similar to ESCs.
- Células madre mesenquimales (MSC): Multipotent stromal cells found in various tissues, como la médula ósea y el tejido adiposo.
- Células madre hepáticas (HSC): Progenitor cells residing within the liver.
4. Mecanismos de acción de las células madre en la regeneración hepática
Stem cells contribute to liver regeneration through several mechanisms:
- Diferenciación: Stem cells can differentiate into mature hepatocytes and other liver cell types, replacing damaged tissue.
- Efectos paracrinos: Las células madre secretan factores de crecimiento., citoquinas, and other molecules that promote liver cell proliferation, migración, and survival.
- Inmunomodulación: Stem cells regulate immune responses, reducing inflammation and fibrosis, which are detrimental to liver regeneration.
