Terapia con células madre de la epilepsia .
La epilepsia como uno de los trastornos neurológicos más comunes afecta a más de 50 millones de personas en todo el mundo con una tasa de prevalencia más alta en los países de bajos ingresos. Las descargas eléctricas excesivas en las neuronas después del daño o la pérdida de células neurales provocan convulsiones recurrentes. One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (TLE) which results from hippocampal sclerosis. Nowadays, similar to other diseases, epilepsy also is a candidate for treatment with different types of stem cells.
Various stem cell types were used for treatment of epilepsy in basic and experimental researches.
Two Terapia con células madre has been shown efficacious in treating experimental models of neurological disorders, incluyendo la enfermedad de Parkinson, and neuropsychiatric diseases, such as depression
Major roles of terapia con células madre in epilepsy are prophylaxis against chronic epilepsy and amelioration cognitive function after the occurrence of TLE.
Células madre pluripotentes inducidas (iPSC)
Some epilepsies are caused because of a genetic mutation or change in neurons. Por ejemplo, Dravet syndrome is a devastating form of childhood epilepsy caused by a mutation in a specific sodium channel.
Scientists have found a way to take stem cells from people with Dravet syndrome and program them to become any type of cell in the body. These new cell types are called células madre pluripotentes. These new cells can be made into neurons.
Although much more research needs to be done, terapia con células madre is an attractive and promising treatment for epilepsy.
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