Stem Cell Therapy for Cholestasis: 概述
Cholestasis, a condition characterized by impaired bile flow, can lead to liver damage and fibrosis. 目前的治疗选择有限且往往无效. 干细胞治疗 has emerged as a promising approach for cholestasis treatment, 提供组织再生和功能恢复的潜力.
Current Challenges in Cholestasis Treatment
Conventional cholestasis treatments, such as ursodeoxycholic acid and cholestyramine, provide symptomatic relief but do not address the underlying cause. Liver transplantation is the only curative option for end-stage cholestasis, but it is limited by donor availability and the risk of complications.
Stem Cells as a Potential Therapeutic Option
干细胞具有自我更新和分化成各种细胞类型的能力. Their regenerative potential makes them an attractive therapeutic option for cholestasis, where damaged liver cells can be replaced or repaired. 干细胞可以有多种来源, 包括骨髓, 脂肪组织, 和脐带血.
Types of Stem Cells for Cholestasis Treatment
Different types of stem cells have been investigated for cholestasis treatment. 间充质干细胞 (间充质干细胞) are multipotent cells that can differentiate into various cell types, 包括肝细胞. 肝干细胞 (造血干细胞) are liver-specific stem cells that can regenerate liver tissue. 胚胎干细胞 (ESC) are pluripotent cells that can differentiate into any cell type in the body.
