Stem cell-based implants successfully secrete insulin in patients with type 1 糖尿病

Stem cell-based implants successfully secrete insulin in patients with type 1 糖尿病
日期:
December 2, 2021
来源:
Cell Press
概括:
Interim results from a multicenter clinical trial demonstrate insulin secretion from engrafted cells in patients with type 1 糖尿病. The safety, tolerability, and efficacy of the implants, which consisted of pancreatic endoderm cells derived from human pluripotent stem cells (PSCs), were tested in 26 患者. While the insulin secreted by the implants did not have clinical effects in the patients, the data are the first reported evidence of meal-regulated insulin secretion by differentiated stem cells in human patients.