干细胞疗法 holds promise for treating infection-related kidney damage, a significant health concern worldwide. This article explores the potential of stem cells in renal repair, discussing the pathogenesis of infection-related kidney damage, 干细胞来源, 递送方法, 临床前和临床研究, and future directions in stem cell-based renal regeneration.
Stem Cell Therapy for Infection-Induced Renal Impairment
Infection-related kidney damage, 从急性肾脏损伤到慢性肾脏疾病, poses a substantial clinical challenge. Traditional treatment options are often limited in efficacy, 强调对新型治疗方法的需求. 干细胞疗法 emerged as a promising strategy due to the regenerative and immunomodulatory properties of stem cells.
Pathogenesis of Infection-Related Kidney Damage
Infection-related kidney damage can result from various pathogens, including bacteria, 病毒, and fungi. These pathogens invade renal parenchyma, triggering an inflammatory cascade that leads to tissue injury. Inflammatory mediators, such as cytokines and chemokines, recruit immune cells to the kidneys, causing further damage. 而且, infection can disrupt the glomerular filtration barrier, leading to proteinuria and renal dysfunction.
