Introduction to Advanced Stem Cell Therapies in Spinal Injury
脊髓损伤 (SCIs) are devastating conditions that can cause permanent paralysis, loss of sensation, and other debilitating symptoms. Cartilage damage is a common complication of SCI, 导致疼痛, 刚性, and further neurological deficits. Advanced stem cell therapies offer promising approaches for cartilage regeneration in SCI, aiming to restore function and improve quality of life for affected individuals.
The Role of Stem Cells in Cartilage Regeneration
干细胞是非特化细胞，具有分化成各种细胞类型的潜力, 包括软骨细胞 (软骨细胞). In cartilage regeneration, stem cells can be used to replace damaged or lost chondrocytes, 促进组织修复和功能恢复.
Types of Stem Cells Used in Cartilage Regeneration
Several types of stem cells are being investigated for cartilage regeneration in SCI:
Mesenchymal Stem Cells for Spinal Cord Injuries
间充质干细胞 (间充质干细胞) 是源自各种组织的多能干细胞, 包括骨髓和脂肪组织. MSCs can differentiate into chondrocytes and other cell types involved in cartilage formation.
Induced Pluripotent Stem Cells for Cartilage Repair
诱导多能干细胞 (诱导多能干细胞) are reprogrammed adult cells that regain pluripotency, 与胚胎干细胞相似. iPSCs can be differentiated into chondrocytes and other cell types, offering a patient-specific approach to cartilage regeneration.
Embryonic Stem Cells in Cartilage Regeneration
胚胎干细胞 (ESC) are pluripotent stem cells derived from early-stage embryos. ESC 具有分化为体内所有细胞类型的潜力, 包括软骨细胞. 然而, ethical concerns and technical challenges limit their use in clinical applications.
