- 骨关节炎
Intravenous infusion of autologous MSCs has shown positive results in osteoarthritis by reducing joint pain, 改善流动性, and decreasing inflammation. Patients often experience improved cartilage preservation and less joint stiffness. The mechanisms include immunomodulation through secretion of anti-inflammatory cytokines, paracrine effects stimulating cartilage repair, and inhibition of catabolic enzymes that degrade cartilage matrix. MSCs home to inflamed joints via systemic circulation and promote tissue regeneration while suppressing chronic inflammation. - 类风湿关节炎
MSC therapy can significantly alleviate symptoms of rheumatoid arthritis, such as joint swelling, 疼痛, and stiffness. Improvements include better joint flexibility and reduced need for immunosuppressive drugs. MSCs work by modulating the overactive immune response, decreasing pro-inflammatory cytokines (like TNF-α and IL-6), promoting regulatory T-cell activation, and directly suppressing autoreactive lymphocytes. Their systemic anti-inflammatory actions help protect joint structures from further damage. - 强直性脊柱炎
Patients with ankylosing spondylitis benefit from MSC infusions through decreased spinal stiffness, 减轻疼痛, and improved flexibility. MSCs exert effects by targeting systemic inflammation, secreting anti-inflammatory factors, and modulating Th17/Treg cell balance. 此外, MSCs reduce fibrosis in spinal ligaments and help maintain vertebral mobility. Their ability to home to sites of inflammation through chemokine signals ensures targeted therapeutic action. - 银屑病关节炎
MSC therapy offers relief for psoriatic arthritis, leading to reduced joint pain, improved skin conditions, and better mobility. Mechanistically, MSCs downregulate Th17-driven inflammatory pathways, suppress keratinocyte hyperproliferation, and enhance skin repair via paracrine signaling. By migrating to inflamed tissues, MSCs not only protect joints but also improve skin lesions associated with psoriasis, contributing to an overall improvement in quality of life. - 系统性红斑狼疮 (系统性红斑狼疮)
In SLE, MSC infusions lead to reduced systemic inflammation, improved skin health, and decreased joint pain. MSCs achieve this by suppressing autoreactive B and T cells, increasing regulatory T cell populations, and reducing production of pathogenic autoantibodies. Through homing to inflamed organs, MSCs stabilize immune activity and promote tissue repair, particularly in kidneys, 皮肤, and joints affected by lupus.
结肠镜检查和胃镜检查完整指南: 期待什么和视频资源
结肠镜检查和胃镜检查完整指南: 期待什么和视频资源 现代医学为检测消化道疾病提供了高效的诊断工具. 两个最重要的手术是结肠镜检查 阅读更多