Terapia con cellule staminali per la malattia di Huntington.

Malattia di Huntington (HD) è una malattia geneticamente ereditaria che distrugge i “neuroni spinosi medi” (MSN) nel cervello, portando a cambiamenti emotivi, declino mentale e movimento compromesso.
La triade clinica della MH comprende la corea, disturbi psichiatrici/comportamentali e declino cognitivo.

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Effetti benefici della terapia con cellule staminali

have been reported for transplantation of stem cells derived
from non-neural tissue, Per esempio, mesenchimale- and adipose-derived stem cells, which have mainly been attributed to their secretion of growth and neurotrophic factors.
iPSCs and embryonic stem cells may be able to make large numbers of neural stem cells.
People with the degenerative disorder Huntington’s disease could receive treatment with stem cells
to slow development of symptoms.
Cellule staminali mesenchimali (MSC) have been shown to have significant effects on restoring synaptic connections between
damaged neurons, promoting neurite outgrowth, secreting anti-apoptotic factors in the brain, and regulating inflammation.
Many trials have assessed the safety and efficacy of human MSC delivery to neuronal tissues via systemic IV infusion.
terapia con cellule staminali