Stem Cell Therapy for Cholestasis: Un aperçu
Cholestasis, a condition characterized by impaired bile flow, can lead to liver damage and fibrosis. Les options de traitement actuelles sont limitées et souvent inefficaces. Thérapie par cellules souches has emerged as a promising approach for cholestasis treatment, offrant un potentiel de régénération tissulaire et de restauration fonctionnelle.
Current Challenges in Cholestasis Treatment
Conventional cholestasis treatments, such as ursodeoxycholic acid and cholestyramine, provide symptomatic relief but do not address the underlying cause. Liver transplantation is the only curative option for end-stage cholestasis, but it is limited by donor availability and the risk of complications.
Stem Cells as a Potential Therapeutic Option
Les cellules souches possèdent la capacité de s’auto-renouveler et de se différencier en différents types de cellules. Their regenerative potential makes them an attractive therapeutic option for cholestasis, where damaged liver cells can be replaced or repaired. Les cellules souches peuvent provenir de diverses sources, y compris la moelle osseuse, tissu adipeux, et le sang du cordon ombilical.
Types de cellules souches pour le traitement de la cholestase
Différents types de cellules souches ont été étudiés pour le traitement de la cholestase. Cellules souches mésenchymateuses (MSC) are multipotent cells that can differentiate into various cell types, y compris les cellules hépatiques. Cellules souches hépatiques (HSC) are liver-specific stem cells that can regenerate liver tissue. Cellules souches embryonnaires (ESC) are pluripotent cells that can differentiate into any cell type in the body.
