Dopamine – 2024
conférence internationale
Peut 19-20
Chers collègues,
bienvenue à la conférence internationale : ” Dopamine” !
C'est pour nous un grand plaisir et un privilège de vous inviter à participer au Dopamine conférence médicale. La NBScience Society prévoit une réunion d'un intérêt et d'une qualité scientifiques exceptionnels dans ce magnifique endroit. – Kiev,Ukraine.
Le programme scientifique a été minutieusement préparé et organisé par le Comité Scientifique. Comme toujours, il permettra une couverture majeure des principaux domaines cliniques d’intérêt , et il présentera également des découvertes scientifiques de pointe. Il y aura un programme CME étendu le jour de la cérémonie d'ouverture, comme d'habitude l'un des joyaux de la couronne des conférences NBScience, et dans le cadre de ce programme, il y aura de nombreuses présentations des groupes de travail NBScience. Comme toujours, la session d'essais cliniques de dernière minute promet d'être passionnante et stimulante. The Young Scientists Platform will also be prominent in the conference programme.
Join us for the Dopamine Meeting!
This is the meeting where scientists develop new technologies to enhance what they see therefore allowing them to do their job better.
Please contact NBScience Education department about customising content to meet your needs.
LIMITED SEATS ! REGISTRATION OPEN ON FIRST COME, FIRST SERVE BASIS
Access the highest quality of education and the latest advancements:
*Earn CME credit.
*Learn from accomplished faculty across a variety of subspecialties.
*Enhance your skills and performance.
We are all really hoping you will find welcoming, the programme exciting, the company stimulating and the experience enriching. We look forward very much to welcoming you for the Dopamine conference.
Sincèrement,
NBScience Events Department
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Outside the central nervous system, dopamine functions primarily as a local chemical messenger. In blood vessels, it inhibits norepinephrine release and acts as a vasodilator (at normal concentrations); dans les reins, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it.
Several important diseases of the nervous system are associated with dysfunctions of the dopamine system, and some of the key medications used to treat them work by altering the effects of dopamine. La maladie de Parkinson, une maladie dégénérative provoquant des tremblements et une déficience motrice, est causée par une perte de neurones sécrétant de la dopamine dans une zone du mésencéphale appelée substance noire.
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Voyage:
Thèmes de conférence:
Jour 1
Maladie, troubles, et pharmacologie
Le système dopaminergique joue un rôle central dans plusieurs conditions médicales importantes, y compris la maladie de Parkinson, trouble déficitaire de l'attention avec hyperactivité, schizophrénie, et la dépendance. Mis à part la dopamine elle-même, il existe de nombreux autres médicaments importants qui agissent sur les systèmes dopaminergiques dans diverses parties du cerveau ou du corps..
Cerveau vieillissant
A number of studies have reported an age-related decline in dopamine synthesis and dopamine receptor density (c'est-à-dire, the number of receptors) dans le cerveau
This decline has been shown to occur in the striatum and extrastriatal regions.
Other neurotransmitters, such as serotonin and glutamate also show a decline in output with aging.
La maladie de Parkinson
Parkinson’s disease is an age-related disorder characterized by movement disorders such as stiffness of the body, slowing of movement, and trembling of limbs when they are not in use.
Drug addiction and psychostimulants
Diagram describes the mechanisms by which cocaine and amphetamines reduce dopamine transporter activity.
Cocaine increases dopamine levels by blocking dopamine transporters (QUE), which transport dopamine back into a synaptic terminal after it has been emitted.
Cocaine, substituted amphetamines (including methamphetamine), Adderall, méthylphénidate (commercialisé sous le nom de Ritalin ou Concerta), MDMA (extase) et d'autres psychostimulants exercent leurs effets principalement ou partiellement en augmentant les niveaux de dopamine dans le cerveau par divers mécanismes.
Le système dopaminergique joue un rôle crucial dans plusieurs aspects de la dépendance. Au stade le plus précoce, les différences génétiques qui modifient l'expression des récepteurs de la dopamine dans le cerveau peuvent prédire si une personne trouvera les stimulants attrayants ou aversifs
La consommation de stimulants entraîne une augmentation des niveaux de dopamine dans le cerveau qui dure de quelques minutes à quelques heures.
Enfin, l'élévation chronique de la dopamine qui accompagne la consommation répétitive de stimulants à haute dose déclenche un large éventail de changements structurels dans le cerveau qui sont responsables des anomalies comportementales qui caractérisent une dépendance..
Treatment of stimulant addiction is very difficult, because even if consumption ceases, the craving that comes with psychological withdrawal does not.
Even when the craving seems to be extinct, it may re-emerge when faced with stimuli that are associated with the drug, such as friends, locations and situations.
Psychosis and antipsychotic drugs
Psychiatrists in the early 1950s discovered that a class of drugs known as typical antipsychotics (also known as major tranquilizers), were often effective at reducing the psychotic symptoms of schizophrenia. The introduction of the first widely used antipsychotic, chlorpromazine (Thorazine), in the 1950s, led to the release of many patients with schizophrenia from institutions in the years that followed.
By the 1970s researchers understood that these typical antipsychotics worked as antagonists on the D2 receptors.
This realization led to the so-called dopamine hypothesis of schizophrenia, which postulates that schizophrenia is largely caused by hyperactivity of brain dopamine systems.
Jour 2
Trouble d'hyperactivité avec déficit de l'attention
Altered dopamine neurotransmission is implicated in attention deficit hyperactivity disorder (TDAH), a condition associated with impaired cognitive control, in turn leading to problems with regulating attention (attentional control), inhibiting behaviors (inhibitory control), and forgetting things or missing details (mémoire de travail), among other problems.
Douleur
Dopamine plays a role in pain processing in multiple levels of the central nervous system including the spinal cord, periaqueductal gray, thalamus, noyaux gris centraux, and cingulate cortex.
Decreased levels of dopamine have been associated with painful symptoms that frequently occur in Parkinson’s disease.
Nausea
Nausea and vomiting are largely determined by activity in the area postrema in the medulla of the brainstem, in a region known as the chemoreceptor trigger zone.
Dopamine sources
Dopamine consumed in food cannot act on the brain, because it cannot cross the bloodbrain barrier. Cependant, there are also a variety of plants that contain L-DOPA, the metabolic precursor of dopamine.
The highest concentrations are found in the leaves and bean pods of plants of the genus Mucuna, especially in Mucuna pruriens (velvet beans), which have been used as a source for L-DOPA as a drug.
In a species of marine green algae Ulvaria obscura, a major component of some algal blooms, dopamine is present in very high concentrations, estimated at 4.4% of dry weight. There is evidence that this dopamine functions as an anti-herbivore defense, reducing consumption by snails and isopods.
Dopamine pharmacology, medicines, recherche clinique
Vous souhaitez savoir si les programmes cliniques actuels, développements de la recherche, ou des approches thérapeutiques émergentes peuvent être pertinentes à votre situation?
Informations pédagogiques et de recherche uniquement. Les décisions médicales individuelles doivent être prises en consultation avec des professionnels de santé qualifiés..
