This compilation of ‘Spetses Summer Schools’ is dedicated to Professor Dr. Marianne Grunberg-Manago, Paris. In 1996, it was 30 years since these renowned Summer Schools in Molecular and Cell Biology came into existence largely through the initiative of Mme. Grunberg-Manago. Following the first Advanced Study Institute in 1966 held on the Island of Spetsai, Summer Schools devoted to topics of current interest were organized annually. These courses have had great success over the years, because they have attracted internationally acclaimed scientists as lecturers as well as excellent student participants from all over the world. The relaxed and pleasant atmosphere always fostered fruitful discussions and social interactions between the students and the lecturers. In 2006. we can celebrate the 40th Anniversary of the Spetses Summer Schools.
The first part, up to the Summer School in 1988, has been reproduced from a similar compilation, which has been published as an Annex to the Proceedings of a NATO/FEBS Advanced Research Workshop on ‘Evolutionary Tinkering in Gene Expression’ held August 29-31, 1988 in Spetsai (اليونان) – NATO ASI Series: Life Sciences, vol. 169 (م. Grunberg-Manago, B.F.C. Clark and H.G. Zachau, eds.), Plenum Press, New York and London, 1989.
SPETSAI 1996
سبتمبر 2 – سبتمبر 12
MECHANISMS IN EUKARYOTIC GENE REGULATION
Organizers: ح. Feldmann (م?nchen)(chairman), A.E. Evangelopoulos (أثينا), دبليو. ح?rz (م?nchen), H.-G. Klobeck (م?nchen)
Lecturers and Lectures:
Piet Borst (Amsterdam): (i) و (ii) Molecular mechanisms of antigenic variation in African trypanosomes.
Margret Buckingham (Paris): (i) Myogenesis: Myogenic factors and muscle gene regulation; (ii) Myogenic factors and muscle cell determination.
Horst Feldmann (م?nchen): The yeast genome project: what do we learn from a simple eukaryote?
David Glover (Dundee): (i) The eukaryotic cell cycle. (ii) Cell cycle regulation in ذبابة الفاكهة.
Frank Grosveld (Rotterdam): (i,ii) Organization and locus-specific regulation of the globin genes.
Peter Gruss (ز?ttingen): (i) Molecular analysis of the vertebral visual system development. (ii) The use of gene trap to identify mammalian developmental control genes.
Peter Herrlich (Karlsruhe): (i) Signal transduction to transcription factors. (ii) The role of adhesion molecules in determining genetic programs.
Jonathan Hodgkin (Cambridge): (i) Genomic analysis of the nematode Caenorhabditis elegans: towards the complete DNA sequence of a simple animal. (ii) Sex determination and mechanisms of developmental gene control in the nematode ج. ايليجانس.
Wolfram H?rz (م?nchen): (i) Regulation of gene expression by nucleosomes. (ii) Mechanism of chromatin activation at the PHO5 promoter.
Herbert J?ckle (ز?ttingen): (i) Transcription factors in ذبابة الفاكهة تطوير. (ii) Homeotic and gap genes in ذبابة الفاكهة.
Fotis C. Kafatos (Heidelberg): (i) Multifunctional transcription factors in ذبابة الفاكهة development and evolution. (ii) Molecular genetic studies of a major insect vector of disease, the malaria mosquito.
Michael Karin (سان دييغو): (i) Signal transduction from cell surface receptors to the nucleus. (ii) Control of cell-type specific gene expression: the growth hormone gene and the anterior pituitary.
Hans-Gustav Klobeck (م?nchen): (i) و (ii) Control of immunoglobulin gene assembly during B cell development.
Rudi J. Planta (Amsterdam): (i) Global regulators of gene expression in yeast. (ii) Heterologous gene expression in yeast.
Walter Schaffner (ز?rich): (i) Transcriptional activation and repression at a distance. (ii) MTF-1, a key factor for heavy metal-regulated gene expression in mammalian cells.
Ueli Schibler (Geneva): (i) Transcription activation by an RNA polymerase II holoenzyme complex. (ii) PAR-family transcription factors and circadian rhythmicity
Andr? Sentenac (Gif-sur-Yvette): (i) و (ii) Yeast polymerase III transcription: a paradigm for gene activation.
Kevin Struhl (Harvard, Boston): (i) Mechanism of transcriptional activation. (ii) Global transcriptional repression mechanisms.
Inder M. Verma (سان دييغو): (i) Function of NF-kB/rel/I-kB proteins. (ii) Gene therapy.
Robert Weinberg (Cambridge MA): (i) و (ii) pRB, cyclins and control of cell proliferation.
Charles Weissmann (Zurich): (i) Generation of animal models of human disease: principles and methods. (ii) The role of PrP in prion disease.
Alan P. Wolffe (Bethesda MD): (i) Histones, nucleosomes and the role of chromatin structure in transcriptional control. (ii) Global control of transcription and translation during early development.
Hans G. Zachau (م?nchen): (i) Human and other genome projects. (ii) The immunoglobulin genes and their acrobatics.
Participants:
A.Abroi (Tartu), P.Alen (Leuven), G.Alexandru (Bucuresti), E.K.Amankwah (Bergen), Nina Aro (Helsinki), A.Atalay (Ankara), A.Bahr (Illkirch), ح. Balkan-Mergen (Ankara), U.Baron (Heidelberg), G.Baur?ن (Stockholm), M.Bencina (Ljubljana), L.Bjergbaek (Aarhus), L.Bogomolnaya (Moscow), S.Borda (Szeged), A.Brehm (Heidelberg), J.Brzeski (Warsaw), H.B?ning (م?nchen), M.Bullejos (Granada), R.Burchmore (Portland OR), R.Calligaris (Trieste), G.Cavalli (Heidelberg), A.Chabes (Ume?), N.Chernyaeva (Moscow), P.Cheung (Hamilton, Ontario), L.Ciapponi (Pomezia Rome), M.A.Cohen (نيويورك), N.Daly (Dublin), G.Di Matteo (Roma), M.Dimitrova (Strasbourg), T.Dincer (Ankara), G.Di Rocco (Milano), A.Echarri Aguirre (Madrid), T.Einbinder (Beer-Sheva), M.Faria (Paris), D.Fear (لندن), A.Freudenstein-Dan (Tel-Aviv), S.Friant (Strasbourg), L.Frostesj? (Umea), A.Gaal (Budapest), I.Garcia-Bassets (برشلونة), B.Gelius (Stockholm), W.G?rner (Vienna), D.Gougoumas (سالونيك), J.H. Gribnau (Rotterdam), J.Hadchouel (Paris), I.Hegyi (ز?rich), M.Hellquist (ز?teborg), L.Hertel (Novara), M.Hinz (Berlin-Buch), Y. Hisatomi (Okazaki), T.Holtschke (Penzberg), أ. Ivanov (Moscow), M.Janitz (Berlin), M.C.J?rgensen (Gentofte), C.Johnston (لندن), J.Joyce (Cambridge), D.Karandrea (أثينا), Z.Karetsou (Ioannina), J.Kirfel (Freiburg), M.Kleines (ك?ln), A.Knutson (Uppsala), L.R.Kockel (Heidelberg), J.Kontaraki (Heraklion), W.Korver (Utrecht), M.Koutsourakis (Rotterdam), S.V.Kozlov (ز?rich), J.Kzhyshkowska (Moscow), M.J.Lafuente (Madrid), C.Larsson (Uppsala), B.Lenhard (Zagreb), D.Liberg (Lund), A.Lin? (Riga), S.Llanos Giron (Madrid), M.Lnenicek-Allen (Portsmouth), L.Lopez-Molina (Gen?ve), S.L?cke (Berlin), I.Mandrika (Riga), A.Moore (Edingburgh), A.M?hlethaler (Gen?ve), C.W.M?ller (Grenoble), M.Nguyen (Paris), S.J.Nielsen (Aarhus), C.O’Conallain (Dublin), P.Emanuel de Oliveira Marujo (Oeiras), M.Pap (Pecs), D.Patterton (Bethesda, دكتوراه في الطب), V Pevzner (Berlin-Buch), A.Pintzas (أثينا), D.Pozo (Seville), C.Provenzano (Rome), A.Pujol (Heidelberg), A.S.Purewal (لندن), C.M.Quinn (Oxford), I.Reimann (Berlin), N.Rethmeier (Gent), A.M.Rezler (Poznan), A.Rezler (Poznan), G.Ries (Basel), D.Robyr (Bethesda, دكتوراه في الطب), O.K.Rodningen (Oslo), T.Ronni (Helsinki), T.E.Rusten (Bergen), S.Samakoglu (Antalya), R.Santoro (Jena), U.Schwidetzky (Berlin), M.Shoresh (Tel-Aviv), E.Sigurdsson (Reykjavik), O.Simonova (Moscow), E.Smirnova (Moscow), I.Spitsyna (Dniepropetrovsk), F.Spitz (Paris), C.Springer (Erlangen), J.Svaren (شارع. Louis, MO), G.K.Stefanakis (أثينا), H.Thonberg (Stockholm), م. de Castro Tom? (Coimbra), I.Udalova (Oxford), S.Vambrie (Wien), D.J. Van Antwerp (سان دييغو, كاليفورنيا), W.Van den Berghe (Gent), T.B. van Dijk (Utrecht), ح. Van Doorninck (Rotterdam), R.Wellinger (ز?rich), C.Wood (Liverpool), A.Zacharova-Albinger (ز?rich), A.M.Zeeman (Leiden), K.Zeng (Kassel), R.Zichel (Rehovot).
SPETSES 1997
سبتمبر 1 -14
BIOMOLECULAR RECOGNITION
Organizers: B.F.C. Clark (Aarhus), A.E. Evangelopoulos (أثينا), A.R. Fersht (Cambridge)
Lecturers and Lectures:
Brian Clark (Aarhus): Activation of GTP-binding proteins: translation factors. Implications of the structure of the ternary complex.
Valerie Daggett (Seattle): Molecular dynamics studies of intramolecular protein recognition: protein folding /unfolding.
Alan Fersht (Cambridge): Protein folding في المختبر: from chaperones to minichaperones.
Marianne Grunberg-Manago (Paris): RNA folding and RNA translation control.
Ulrich Hartl (نيويورك): Protein folding with molecular chaperones.
Hennie Hoogenboom (Maastricht): Phage display based tools to generate and study biomolecular interactions: Designing and optimizing phage-based strategies for generating high-affinity antibodies.
Morten Kjeldgaard (Aarhus): From crystal to model. Structure and function of the family of the G-proteins.
Peter Laing (Cambridge): Consensus as a tool of structural inference: generation of ligand models from peptide libraries.
Dino Moras (Strasbourg): tRNA aminoacylation. The ligand binding domain of nuclear receptors: 3D structure and functional correlations.
Poul Nissen (Aarhus): RNA-protein recognition.
Martin Noble (Oxford): Protein kinases and the role of phosphorylation. Protein interactions in the regulation of the cell cycle.
Sheena Radford (Leeds): Protein folding mechanisms: recent insights using biophysical methods. Protein misfolding and amyloidosis.
Tony Rees (Bath): The design of allosteric switches in proteins. الأجسام المضادة.
Daniela Rhodes (Cambridge): Telomeric DNA recognition. Protein-DNA recognition.
Chris Sander (Cambridge): Mapping the protein universe.
Gottfried Schatz (Basel): Protein import into mitochondria as a paradigm of protein transport across biological membranes.
Manfred Schneider (Wuppertal): Lipases as catalysts in organic synthesis.
Gideon Schreiber (Rehovot): Mechanism of protein-protein interaction.
Tom Steitz (Yale): Structural principles of protein nucleic-acid interactions with emphasis on RNA structural diversity and recognition. DNA and RNA polymerases: structural diversity and common mechanisms.
Mathias Uhlen (Stockholm): Scaffolds for engineering novel binding sites in proteins. Affibodies – binding proteins selected from combinatorial libraries.
Eric Westhoff (Strasbourg): Tools for studying RNA structure and folding. RNA tectonics. The modular and hierarchical assembly of group I introns.
Fred Wittighofer (Dortmund): Signal transduction via small GTP-binding proteins. Ras as a paradigm: (أ) interaction with effectors, (ب) the turn-off mechanism of the molecular switch – the GTPase reaction.
Kurt W?thrich (Zurich): Macromolecular recognition studied by NMR. Prion structure and transmissible spongiform encephalopathies.
Zhaohui Xu (Yale): The crystal structure of the bacterial chaperonin complex GroEL.GroES.(ADP)7. Structure and functional studies of chaperonin-assisted protein folding.
Participants:
ك. Alexandrov (Dortmund), M.Altamirano (Cambridge), P.Alves (Lisboa), ك. Andersson (Lund), ه. Balcan (Izmir), ح. Barrios (Cuernavaca Morelos, المكسيك), ص. Beatus (Stockholm), ت. Bengtson (Stockholm), ج. Berset (Bern), T.Celius (Bergen), س. Chetyrkina (كييف), F. Christ (Giessen), ز. Cingolani (Grenoble), ز. Conn (Baltimore), F. Constantinesco (Gif-sur-Yvette), أ. Danielewicz (Cleveland), س. Das (New Delhi), م. Daub (Dortmund), M.C. Deller (Gif-sur-Yvette), م. Deniziak (Gif-sur-Yvette), م. Dickman (شيفيلد), ه. Enchev (Sofia), K.N. Engin (Istanbul), F. Guarino de Felice (Rio de Janeiro), الخامس. De Filippis (Padova), ج. Fladeby (Bergen), P.G. Foster (سان فرانسيسكو), أنا. Galetich (Kharkov), أ. Gawlak (Poznan), J. Gille (Frankfurt), ب. Guerra (Odense), Y.V. Guervaziev (Moscow), C.S. Hamnn (Philadelphia), ت. Hamelryck (Rhodes St. Genese), أ. Hendrick (Cork), أنا. Hoch (vienna), M.-R. Hoja (Uppsala), O. Ignatovich (Cambridge), ك. Johansson (Uppsala), H.F. J?rgensen (Aarhus), ت. Killick (Cambridge), ز. Klein (Gdansk), أ. Kondo (طوكيو), م. Kontou (Uppsala), E.A. Kovrigina (Pushino), م. Krogsgaard (Copenhagen), B.L: Kuehl (Dundee), أ. Ladurner (Cambridge), ش. Langhorst (Rhodes St. Genese), د. Larkin (Houston), م. Laurberg (Lund), Yin-fai Lee (Cambridge), E.V. Levsshenkova (Moscow), ت. Linnemann (Dortmund), م. Macht (Konstanz), ز. Malpeli (Parma), أ. Malygin (Novosibirsk), أ. Mans?ن (Stockholm), أنا. Marchand (Paris), م. Marinou (أثينا), ب. Masquida (Strasbourg), ر. McCarthy (Bath), أ. Merlin (Freiburg), ه. Moreno (Madrid), O.N. Murashko (Minsk), D.A. Murtazina (Moscow), ر. Mutuberria (Maastricht), J. Nielsen (Heidelberg), م. Ninkovic (Jena), ص. Nissen (Aarhus), س. ?nal (Izmir), أ. Palsson (Reykjavik), د. Papanastassiou (أثينا), ز. Patikoglou (New Haven), H.H. Petersen (Aarhus), ج. Petropoulou (أثينا), N. Polacek (Vienna), N. Popescu (Bucuresti), F. Possmayer (Paris), ه. Psichari (أثينا), أ. Rak (Pushino), ح. Reiersen (Bath), ل. Reynolds (Portsmouth), م. Righi (Trieste), ر. Roovers (Maastricht, ك. Sak (Tartu), ج. sauter (Strasbourg), م. Schneider (Wuppertal), أ. Serganov (Pushino), م. Shapira (Jerusalem), م. Sloma (Stockholm), ص. Stanislawski (Warsaw), N.N. Starkova (Moscow), الخامس. Subramaniam (ز?ttingen), ل. Supino-Rosin (Ramat-Avis), ج. Takemoto (طوكيو), J. Tame (Heslington, York), ح. Taylor (Cambridge), ز. Tocchini-Valentini (Strasbourg), م. Tock (Leeds), ر. Toth (Debrecen), س. Townson (Manchester), ت. Tsouloufis (أثينا), ج. Tzagarakis-Foster (Davis CA), I.P. Uray (Devrecen), س. Ureuqui (Paris), F. Uysal (Izmir), م. Valtavaara (Oulu), د. Verhamme (Amsterdam), ج. Villa (Dortmund), ت. Voronkova (Riga), ر. warth (Geneva), م. Wilcke (Paris), س. Williams (لندن), ت. Wind (Aarhus), O. Yifrach (Rehovot), دبليو. Yong (aarhus), ص. Zajakins (Riga), أنا. Zamfir (Bucuresti), Changqi Zhu (Karlsruhe), ك. Zimna (Poznan).
SPETSES 1998
أغسطس 30 to September 12
MOLECULAR BASIS OF BACTERIAL INFECTION
Organizers: J. Davies (Vancouver), A.E. Evangelopoulos (أثينا), م. Grunberg-Manago (Paris) (Chairman)
Lecturers and Lectures:
ص. Sharp (Nottingham): (1) Microbial diversity: phylogentic studies. (2) Evolution of repetitive sequences in bacteria: ERIC sequences.
م. Radman (Paris): Control of genetic variability in bacteria: mutation, recombination, selection and speciation.
B.M?ller-Hill (Cologne): Negative control of transcription in E.coli.
س. Busby (Birmingham): (1) Positive activation of gene expression in E.coli. (2) Catabolite repression in gram-positive organisms.
م. Grunberg-Manago (Paris): Translational initiation and its control in gram-negative and gram-positive bacteria.
J. McCarthy (Manchester): Control of translation and mRNA stability in yeast.
B.F.C. Clark (Aarhus): (1) Activation of GTP-binding proteins: translation factors. (2) Structure of the ternary complex and role of kyrromycin.
Y. Nakamura (طوكيو): Regulation of translation termination and recoding.
ل. Kisselev (Moscow): Termination in eukaryotes.
ح. Feldmann (Munich): (1) Functional analysis of the yeast genome. (2) Yeast as a model system for programmed proteolysis and pathogenic fungi.
ر. Rappuoli (Siena): New vaccines.
J. Davies (Vancouver): Antibiotics: action and resistance.
ب. Simons (الملائكة): (1) Prokaryotic mRNA decay and its regulation. (2) Antisense RNA and its control – natural and contrived.
ج. Georgopoulos (Geneva): (1) Protein folding, proteolysis and molecular chaperones. (2) Function and regulation of the heat-shock response in Escherichia coli.
ر. Gunsalus (الملائكة): (1) Oxygen control of gene expression in E.coli. (2) Nitrate-dependent signal transduction and gene regulation.
ر. Kolter (Harvard): (1) Bacterial adaptation in stationary phase. (2) Population dynamics during stationary phase.
ص. Stragier (Paris): Cell-specific gene expression during sporulation in ب. subtilis.
ر. Moxon (Oxford): Utility of whole genome sequences of pathogenic bacteria.
د. Holden (لندن): Genetics of bacterial pathogenicity.
J. Miller (الملائكة): Regualtion of bacterial pathogenicity and genetic analysis of virulence factor function.
ز. Cornelis (Louvain): ال Yersinia Yop virulon.
ت. Silhavy (Princeton): Genetic analysis of the general protein secretion pathway.
ص. Cossart (Paris): Listeria monocytogenes: tools and tricks of a bacterial pathogen to invade cells and tissues.
ت. Meyer (دبليو?rzburg): Molecular pathogenesis of Neisseria.
ص. Sansonetti (Paris): Pathogenesis of Shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation.
Participants:
ص. Adams (Southampton), ك. Adelmann (Gif-sur-Yvette), R.M.J. Aamodt (Oslo), م. Ajonye (Bath), م. Ansaldi (Marseille), ر. Asano (Vancouver), ت. Autio (Helsinki), F. Backhed (Stockholm), أ. Balandina (Paris), ص. Benkel (Giessen), B.M.Bjorkholm (Stockholm), J. Bjorkman (Stockholm), K.K.H. Blom (ز?teborg), V.B. Borodulin (Saratov), ت. Brauer-Steppkes (Bochum), K.W. Bruhn (الملائكة), ج. Carnoy (Lille), أنا. Chabchoub (Sfax)), الخامس. Chubanov (Minsk), د. Clarke (Orsay), الخامس. Doroshenko (Moscow), W.A. El-Adhami (Perth), س. Erksson (Stockholm), J.C. Espinosa (Madrid), M.A. Farris (Southampton), T.T. Frederiksen (Aarhus), الخامس. Garcia Palacio (طوكيو), A.M. Geiger (م?nchen), ز. Godaly (Lund), ب. Gonzalez-Zorn (Madrid), س. Grill (Wien), أنا. Gryllos (شيفيلد), أنا. Gustafsson (Uppsala), Long Hang (Lund), R.D. Hayward (Cambridge), Y. Hechard (Poitiers), J. Hein (م?nchen), A.B.E. Helander (ز?teborg), A.M. Hernendez-Arriaga (Madrid), أ. Hobta (كييف), الخامس. Hope (Nottingham), ج. Isak J?rgensen (Odense), E.K.V. Johnsson (Lund), أ. Jordanova (Sofia), ج. Josenhans (Bochum), س. Joyce (Paris), د. Kamashev (Paris), أ. Kasaks (Riga), N. Kinsella (Southampton), J. ك?nig (دبليو?rzburg), ك. Kostelidou (Birmingham), س. Kothandharaman (Madras), ر. Krishnaraj (Palkalaiperur), ك. Krogh Andersen (Dublin), G.I. Kutuzova (Moscow), A.K. Lee (Stanford), P.Lestrate (Namur), د. Llull Penalba (Madrid), ه. Lopez-Solanilla (Madrid), ه. Mamroud-Kidron (Ness-Ziona), R.A. Mateuca (Bucharest), ز. de Medeiros Silva (Oeiras), M.L. Merroun (Granada), P.M. Miranda (Estoril), س. م?ller (Braunschweig), ه. Mutoh (طوكيو), ز. Nawaz (Karachi), الخامس. Nikitina (Saratov), T.I.V. Nogueira (Paris), س. Novella del Campo (Madrid), أ. Olsen (Aarhus), J.A. Oscarsson (Umea), J.M. Palacios Moreno (Aarhus), د. Panne (Basel), M.C. Para Caballero (Madrid), R.M. Parreira (Lisboa), م. Persuh (نيويورك), ص. Peyron (Toulouse), J. Piedade (Lisboa), J. Pizarro-Cerda (Marseille), م. Pope (Vancouver), ك. Ragkousi (Nottingham), أ. Rak (Pushino), P.H. Remane (Braunschweig), ح. Sahly (Kiel), Y.O. Sanogo (Brno), م. Scocchi (Udine), ه. Sergeeva (Saratov), ح. Sinha (Cambridge), ز. Spohn (Siena), P.T. Tassios (أثينا), ت. Tenson (Tartu), A.-C. Thoreson (ز?teborg), ه. Thorolfsdottir (Reykjavik), أ. Tochetti (Milano), أ. Tover (Tartu), N. Tvetkov (Sofia), م. Uno (طوكيو), Y. Vega Rocha (Madrid), ر. Vipond (Salisbury), م. Viveiros Tettencourt (Liboa), م. Vulic (Paris), م. Westermark (Umea), ج. Dammel (Haywward), أ. Miasnikov (Kantvik), D.T. Nieuwlandt (Boulder).
SPETSES 1999
Augst 29 – سبتمبر 9
STRUCTURE AND FUNCTION OF MACROMOLECULAR COMPLEXES
Organizers: Efstathis Gonos (اليونان), Matthias Hentze (ألمانيا), John Hershey (الولايات المتحدة الأمريكية), Lev Kisselev (روسيا), John McCarthy (المملكة المتحدة.)
Lecturers and Lectures:
أغسطس ب?ck (Institut f?r Genetik und Mikrobiologie, Universit?t M?nchen)
(i) Recoding mechanism of the Genetic Code; (ii) Insertion of seleno-cysteines into proteins
Irene Bozzoni (Dipt. Genetica e Biologia Molecolare, La Sapientia, Rome)
(i) & (ii) Sno RNAs: function and biosynthesis
Agamemnon J. Carpousis (مختبر. Microbiologie et G?ن?tique Mol?culaire, Toulouse)
(i) RNA degradation complexes in bacteria; (ii) Bacterial poly(أ) polymerase
Bernhard Dobberstein (Zentrum f?r Molekulare Biologie, Heidelberg)
(i) Protein targeting to the membrane of the endoplasmic reticulum; (ii) Protein translocation across the membrane of the endoplasmic reticulum
Ellie Ehrenfeld (NIH, Bethesda)
(i) Virus replication and gene expression; (ii) Polio virus replication and effects on the host cell
Pamela Green (Plant Research Laboratory, East Lansing)
(i) & (ii) mRNA decay in eukaryotes
Marianne Grunberg-Manago (Institut Pieree et Marie Curie, Paris)
(i) A History of the Spetses Summer School; (ii) mRNA stability and its role in control of gene expression in bacteria and phages
Ulrich Hartl (MPI f?r Biochemie, Martinsried)
(i) & (ii) Function of molecular chaperones and heat-shock proteins in folding proteins
Matthias W. Hentze (EMBL, Heidelberg)
(i) Regulation of translation by RNA-binding proteins; (ii) Recognition of nonsense codons by translation complexes
John W.B. Hershey (Dept. Biological Chemistry, UC Davis)
(i) The pathway and mechanism of initiation of protein synthesis; (ii) The structure-function of eIF3
Walter Keller (Biozentrum, Basel)
(i) 3′-end processing of mammalian mRNA precursors; (ii) 3′-end processing of yeast mRNA precursors
John McCarthy (UMIST, Manchester)
(i) & (ii) Posttranscriptional control: methods, concepts, numbers
Kiyoshi Nagai (MRC. Cambridge)
(i) Structural basis of RNA-protein interactions; (ii) The spliceosome
Yoshikazu Nakamura (Institute of Medical Science, طوكيو)
(i) & (ii) Regulation of translation termination and recoding
Walter Neupert (Adolf-Butenandt-Institut, م?nchen)
(i) & (ii) Topogenesis of proteins of mitochondria
Joan A. Steitz (Yale University, New Haven)
(i) & (ii) Pre-mRNA splicing
Thomas A. Steitz (Yale University, New Haven)
(i) Ribosome structure and function; (ii) Structure and function of protein synthesis elongation factors
Geoffrey Turner (Dept. Molecular Biology and Biotechnology, شيفيلد)
(i) Peptidyl synthetases: Distribution and evolution; (ii) Peptidyl synthetases: Functional analysis
Dieter H. Wolf (Institut f?r Biochemie, Stuttgart)
(i) Structure and assembly of the 26S proteasome, the central proteolytic particle of all eukaryotic cells; (ii) Quality control in the endoplasmic reticulum: retrograde protein transport through the Sec61 translocon and its end in the proteasome
Participants:
Varaklioti Agoritsa (أثينا); Eleftheria Argyrou (أثينا); Patrick Bakkes (Amsterdam); Richard Bayliss (Cambridge, المملكة المتحدة); Natalya Belkina (Moscow); Artemy Beniaminov ((Moscow); Michela Bertero (Pavia); Snaedis Bj?rnsdottir (Reykyavik); Jennifer Blanchette (Ann Arbor); Sergei Boudko (Moscow); Pietro Boyl (Rome); Tatyana Budkevich (كييف); Nuria Campillo (Cambridge, المملكة المتحدة); Anne Carr-Schmid (Piscataway); Gina Clayton (Cambridge, المملكة المتحدة); Siska Cochran (Manchester); Maria Dahle (Oslo); Vita Dauksaite (Uppsala); Aneta Dobruk (Warsaw); Svetlana Dokudovskaya (Moscow); Morten Elholm (Bergen); Alessandro Fatica (Rome); Fedor Forafonov (Saint Petersburg); Silvia Galardi (Rome); Daniela Galli (Rome); Sven Geibel (Frankfurt/M); Zeynep Gerek (Istanbul); Nicholas Glykos (Heraklion); Igor Goncharov (Rehovot); Esther Guarinos (Madrid); Jacoba Stagter J?ger (Uppsala); Alexander Jgoun (Moscow); Pall Jonsson (Kopavogur); Zemfira Karamysheva (طوكيو); Adrej Kariakin (Moscow); James Kastenmayer (East Lansing); Natalya Kholod (Moscow); Mehtap Kilic (Antalya); Sokolov Kirill (Moscow); Nadejda Koloteva (Tel Aviv); Elizaveta Kovrigina (Pushino); Edgar Kramer (Vienna); Inna Krieger Hyogo); Mette Kristensen (Copenhagen); Svetlana Kuptsova (Moscow); Yusuf Kurtumus (?zmir); Sofia Larsson (Huddinge); Susanne Leonhartsberger (Munich); Michael Lisurek (Saarbr?cken); Marco Lutz (Groningen); ?lo Maiv?li (Tartu); Cristina Marino-Busljc (Cambridge,المملكة المتحدة); Kirill Martemyanov (Pushino); Racula Mateuca (Bucharest); Mads Wichmann Matthiesen (Copenhagen); Greg Mayeur (Davis); Jeanne Menez (Paris); Oliver Mohseni (Stockholm); Thorleif M?ller (Odense); Jakob M?ller-Jensen (Odense); Patrick Morris (Little Rock); Oleg Murashko (Minsk); Boris Negrutskii (كييف); Teresa Noguiera (Paris); Joy Okpuzor (Lagos); Christina Olsson (Lund); David Page (Edinburgh); Chariklia Petropoulou (أثينا); Lionel Pintard (Montpellier); Lukia Psaridi (أثينا); Lambrini Psiouri (Patras); Marina Ptushkina (Manchester); Agnes Rinaldo-Matthis (Stockholm); Allison Robb (Edinburgh); Yury Rubtsov (Moscow); Ekatarina Rusakova (Moscow); Cyril Saguez (Gif-sur-Yvette); Chiara Scerch (Monterotondo); Thomas Schell (Heidelberg); Jan Schirawski (Paris); Thomas Sebastian (Kerala); Elena Sergeeva (Saratov); Petr Sergiev (Moscow); Vyacheslav Shalak (كييف); Olga Shpachenko (Moscow); Daria Sizova (Moscow); Vladlen Skvortsov (Moscow); Evgeniya Smirnova (Moscow); Alicia Solorzano (Salamanca); Irina Sominskaya (Riga); Martin Stancek (Stockholm); Margarita Tenopoulou (Ioannina); Martin Thanbichler (Munich); Neslihan Toyran (Ankara); Jennifer Tusz (Szeged); Nikolay Tzvetkov (Nagoya); Louise Unwin (Leeds); Patricia Vazquez (Madrid); Carmen Velasco Ramirez (Manchester); Christina Vilela (Manchester); Stefan Walke (Cambridge,المملكة المتحدة) Daniel Williams (Dundee); Matt Winkler (Austin); Jonathan Wood (Leeds); Wendy Wood (Brighton); Kuniyasu Yoshimura (طوكيو); Natalia Zakataeva (Moscow); Vladimir Zeenko (Basel); Chunying Zhu (Copenhagen).
SPETSES 2000
سبتمبر 5 to September 13
MOLECULAR MECHANISMS OF DEVELOPMENT AND DISEASE
Basic molecular mechanisms of cell function and their implications in disease
Developmental aspects, developmental models
Disease mechanisms
Organizers: Peter Herrlich, Chairman (ألمانيا), Herbert Jaeckle (ألمانيا), Efstathis Gonos (اليونان), Horst Feldmann (ألمانيا)
Lecturers and Lectures:
Patrick Baeuerle (Martinsried/Munich, ألمانيا)
(i) Ordering principles in Signaling/Signal Transduction (ii) Academia and industry: what to learn from each other
Piet Borst (Amsterdam, NL)
(i) Antigenic variation in trypanosomes; (ii) Drug resistance in cancer cells.
Steven Burley
Wolfgang Driever (Freiburg, ألمانيا)
(i) Mechanisms in the development of zebrafish; (ii) الزرد: tools for investigating cellular differentiation.
Walter Gehring (Basel, سويسرا)
(i) Homeobox genes and the specification of the body plan (ii) Master control genes in morphogenesis and evolution of the eyes
Dirk ز?rlich
Peter Gruss (ز?ttingen, ألمانيا)
(i)Molecular mechanisms underlying brain development (ii) Cortex development/Organogenesis
Peter Herrlich (Karlsruhe, ألمانيا)
(i) Mouse mutants for the analysis of transcriptional regulation (ii) Neurofibromatosis Type 2
Jan Hoejimakers
Wolfram ح?rz (Munich, ألمانيا)
(i) Nucleosomes and their interactions with regulatory factors; (ii) Role of the chromatin structure in the expression of the phosphatase gene family in yeast.
Robert Horvitz (Cambridge, الولايات المتحدة الأمريكية)
Programmed cell death in C. ايليجانس
Herbert J?ckle (ز?ttingen, ألمانيا)
(i) Transcription factors in ذبابة الفاكهة تطوير; (ii) homeotic and gap genes in Drosophila.
Rudolf Jaenisch (Cambridge, Massachusetts, USA.)
(i) DNA repair; (ii) Methylation and expression patterns of imprinted and nonimprinted genes.
Fotis C. Kafatos (Heidelberg, ألمانيا)
(i and ii) Innate Immunity and Malaria.
Reinhard ل?hrmann
Iain Mattaij (Heidelberg, ألمانيا)
(i) Nucleocytoplasmic transport; (ii) Ribonucleoprotein assembly
Ueli Schibler (Geneva, CH)
(i) Chronobiology: from cynobacteria to man (ii) Circadian gene expression in animals and cells
Axel Ullrich (Martinsried/Munich, ألمانيا)
Growth factor receptors
Inder M. Verma (San Diego CA, الولايات المتحدة الأمريكية)
(i and ii) Gene therapy.
Robert Weinberg (Cambridge MA, الولايات المتحدة الأمريكية)
(i) Tumor suppressor genes; (ii) موت الخلايا المبرمج.
Charles Weissmann (Zurich, سويسرا)
(i) Prion diseases in animals and humans (ii) Molecular biology of prion diseases
Alan P. Wolffe (Bethesda MD, الولايات المتحدة الأمريكية)
(i) Regulatory roles for chromatin: structure and transcriptional activation (ii) Regulatory roles for chromatin: heterochromatin and transcriptional repression
SPETSES 2001
سبتمبر 4 to September 14
PROTEIN BIOLOGY: FROM SYNTHESIS TO FUNCTION AND DISEASE
Organizers: Brian F.C. Clark (chairman) (Denmark), Alan R. Fersht (المملكة المتحدة), Efstathis Gonos (اليونان), Daniela Rhodes (المملكة المتحدة)
Topics:
(1) Protein Synthesis and Macromolecular Mimicry
(2) Folding and Quality Control
(3) Protein Folding
(4) Targetting and Trafficking
(5) Maturation, Recognition and Degradation
(6) Proteomics and Bioinformatics
(7) Protein Design
(8) Misfolding and Disease
Lecturers:
Wolfgang Baumeister (ألمانيا), Julio Celis (Denmark), Aaron Ciechanover (Israel), Brian Clark (Denmark), Elena Conti (ألمانيا), Chris Dobson (المملكة المتحدة), Alan Fersht (المملكة المتحدة), Susan Grasser (سويسرا), Stathis Gonos (اليونان), Gunnar von Heijne (السويد), Ari Helenius (سويسرا), Matthias Hentze (ألمانيا), Walter Neupert (ألمانيا), Andreas Pl?ckthun (سويسرا), Daniela Rhodes (المملكة المتحدة), Chris Sander (الولايات المتحدة الأمريكية), Luis Serrano (ألمانيا), Mathias Uhlen (السويد), Charles Weissmann (المملكة المتحدة).
Participants:
Charlotta Agaton (KTH, Royal Institute of Technology, س- 100 44 Stockholm, السويد); Burcu Anar (Erasmus University,3000 DR, Rotterdam); Tiziana Anelli (Istituto Scientifico San Raffaela, 20132 Milano);Vassiliki Avramopoulou (Hellenic Pasteur Institute, 115 21 أثينا), Alexandre Avsiouk (Moscow State University, 117333 Moscow ); Natalia Beloglazova (Academy of Sciences 8, Lavrentien Av., 630090, Novosibirsk 90); Petra Berg (CMB, S-171-77 Stockholm ); Angela Bisso (DIMES – Sezione Biochimica, 16132 Genova); Catherine Bruel (Institute of Clinical Biochemistry and Pathobiochemistry, 98078 دبليو?rzburg);Anne-Laure Bulteau (Universit? Paris 7 – Denis Diderot, 75251 Paris Cedex 05); Barbara Campanini (Universit? degli Studi di Parma, 43100 Parma ); Susan L. Campbell (Institute for Animal Health, Edinburgh, EH9 3JF); Andrew Carter (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Pedro Castanheira (Universidade de Coimbre, 3001 401 Coimbra); Marta Rodriguez Castro (Instituto de Salud Carlos III,28220 Madrid); Urska Cegovnik (Institute of Oncology, 1000 Ljubljana); Niki Chondrogianni (National Hellenic Research Foundation, 166 35 أثينا); Daniel Christ (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Robert Court (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Adrian Creanga (Institute of Biochemistry, Bucharest 77700); Robert Dobrovolny (Institute of Inherited Metabolic Diseases, 128 08 Praha 2); Melloney Dr?ge (University of Groningen, 9713 AV Groningen); Marta Fikus (Polish Academy of Sciences, 02-106 Warszawa); Parthena Foltopoulou (Aristotle University of Thessaloniki, Thessalonki 540 06); Linda Frederiksson (Ludwig Institute for Cancer Research, 171 77 Stockholm); Steffen Frey (Zentrum f?r Moleculare Biologie Heidelberg, 69120 Heidelberg); Rikke From Fr?hlich (University of Aarhus, 8000 Aarhus C); Behzad Gharehnia (University of Bergen, 5021 Bergen); Stefania Gobessi (Universit? degli Studi di Udine, 33100 Udine); Alina Grabiec (Jagiellonian University, 31-120 Krakow); Ekaterina Gresko (Inselspital, 3010 Bern); Carol Harty (Cambridge Institute for Medical Research, Cambridge CB2 2XY); Florian Hollfelder (Department of Biochemistry, Cambridge CB2 1GA);Tijana Ignjatovic (MRC Laboratory of Molecular Biology, Cambridge CB2 1TQ); Hideo Iwai (Biochemisches Institut , Universitaet Zurich, CH-8057 Zurich); Ghil Jona (Weizmann Institute of Science, Rehovot); Kim Bak Jensen (University of Aarhus, 8000 Aarhus C); Alexandra Kaser (Austrian Academy of Sciences, 5020 Salzburg); Katin Kepp (University of Tartu, Tartu 51010); Ilkka Lappalainen (University of Helsinki);Michael Lappe (Wolfson College, Cambridge CB3 9BB); Natalia A. Lebedeva (Institute of Bioorganic Chemistry, Novosibirsk 630090 ); Rune Linding (EMBL, D-69117 Heidelberg); Kresten Lindorff-Larsen (2300 ك?benhavn S); Efthimia Lioliou (Aristotle University of Thessaloniki, 54006 سالونيك); Adrianna Loniewska (Polish Academy of Sciences, 02-106 Warszawa); Manuela L?pez de la Paz (European Molecular Biology Laboratory, D-69117 Heidelberg ); Ewan Main (Dept. of Molecular Biophysics and Biochemistry, New Haven, Connecticut 06520-8114); Vlatka Makanec (PLIVA Reseach Institute, 10 000 Zagreb); Francisco Mansilla Castano (University of Aarhus, 8000 Aarhus C); Tomoaki Matsuura (Biochemisches Institut Universitaet Zurich , CH-8057 Zurich); Ugo Mayor (Centre for Protein Engineering, CB2 2DQ Cambridge); Tanja Meriluoto (National Public Health Institute, 00251 Helsinki); Jesper Mogensen (Department of Biotechnology Aalborg University, 9100 Aalborg); Olga V. Molchan (Belorussian Academy of Sciences, Minsk 220072); Zoryana Oliynyk (Centre for Protein Engineering, MRC, Cambridge CB2 2QH); Krzysztof Olszak (Institute of Biochemistry and Biophysics PAS, 02-106 Warsaw); Jennifer L. Ong (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Juha Paloneva (National Public Health Institute, Helsinki); Alla Pogribna (Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, كييف 252143); Rosa Resende (Universidade de Coimbra, 3004 517 Coimbra); Ekaterina Rusakova (Engelhardt Institute of Molecular Biology, 117984 Moscow); Carsten Schwalb (University of Edinburgh, Edinburgh EH9 3JR); Burckhard Seelig (Harvard Medical School, Boston MA 02114); Markus Seeliger (Cambridge University Chemical Laboratory, Cambridge CB2 1EW); Toomas Silla (University of Tartu, Tartu 51010);Frederico Silva (Instituto de Biologia Molecular e Celular, 4150 180 Porto); Federica Sinibaldi (Universita “Tor Vergata” di Roma, 00133 Rome); Elena Sokolova (Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997); Therese Solstad (PKI, IBMB, 5020 Bergen); Teresa Soop (MoG, CMB, Karolinska Institute, 171 77 Stockholm); Tam?s Sperka (University of Debrecen, 4012 Debrecen); Kaare Teilum (Institute of Molecular Biology, University of Copenhagen, 1353 Copenhagen K); Hana Tomincov? (Academy of Sciences of the Czech Republic, 166 37 Praha 6); Ioannis P. Trougakos (National Hellenic Research Foundation (N.H.R.F.), 11635, Athens Greece); Katharina Reksten Tufteland (University of Bergen, HIB, 5020 Bergen); Ann Vanhooren (Catholic University Leuven ,8500 Kortrijk); Lidia Vasilieva (University of Helsinki, 00014 Helsinki); Ioulia Vassilieva (Institute of Protein Research, 142290 Pushchino, روسيا); Ana V. Vilar (Universitat de Barcelona, 08028 برشلونة);Gordon Whamond (University College London, London WC1E 6BT); Kate Wickson (UMIST, Manchester M60 1QD); Anna Zajakina (University of Latvia, Riga LV 1067); Bernd Buchberger Roche Diagnostics GmbH, Werk Penzberg, Nonnenwald 2, 82372 Penzberg, ألمانيا); Christine Dartsch (AstraZeneca Biotech Lab, ب:841, 151 85 س?dert?lje, السويد)
SPETSES 2002
سبتمبر 3 to September 13
MOLECULAR BIOLOGY OF BACTERIAL INFECTIONS
Organizers: Pascale Cossart (Institut Pasteur, فرنسا)(Chairperson), Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية); Efstathios Gonos (Hellenic Research Foundation, اليونان).
Topics:
Invasive bacteria
Regulation
Protein export and secretion in bacteria
Intravacuolar pathogens
Genomics/ Post Genomics
Bacterial toxins
Virulence genes organisation
Evading the host defense systems
Evading hostile environments
Antiphagocytosis
Lecturers and Lectures:
Patrice Boquet (Nice, فرنسا)
Bacterial toxins : basic concepts (i) ; Bacterial toxins : what do these proteins tell us about host cell molecular mechanisms (ii)
Pascale Cossart (Paris, فرنسا)
Genetics and Cell biology of Listeria infections: from in vitro to in vivo data (i); Listeria monocytogenes : new insights in virulence (ii)
Guy Cornelis (Bruxelles, بلجيكا)
The Yersinia injectisome (i); The cell biology of the Yop effectors (ii)
Antonello Covacci (Siena, إيطاليا)
Virulence factors in Helicobacter pylori, Pathogenicity islands and Cell biology (i); Bioinformatics and Microbes (ii)
Julian Davies (Vancouver, كندا)
What is an antibiotic (i); The complexity of antibiotic resistance (ii)
Efstathios S. Gonos (أثينا, اليونان)
The molecular genetics of human ageing and longevity
David Holden (لندن , المملكة المتحدة)
Methods to study Salmonella virulence in vivo (i); Intracellular Biology of Salmonella (ii)
Roberto Kolter (Boston, الولايات المتحدة الأمريكية)
Thinking about bacteria as multicellular organisms : implications to pathogenesis and survival (i); Bacterial biofilms in chronic infections (ii)
Gunnar Lindahl (Lund, السويد)
Bacterial immuno-globulin binding proteins and their role in virulence (i); Antigenic variation and its molecular basis : Group A Streptococcus as a model system (ii)
Jeff Miller (الملائكة, الولايات المتحدة الأمريكية)
A mechanistic, evolutionary and ecological perspective on bacterial gene regulation (i); Parasite adaptations to dynamic hosts: the infectious cycles of Bordetella and their phages
Edgardo Moreno (Heredia, Costa Rica)
Brucella pathogenesis
Tony Pugsley (Paris, فرنسا)
تاريخ, background and relationships to other protein translocation systems (i); One, two and three membranes (ii)
Philippe Sansonetti (Paris, فرنسا)
What is a pathogen ? (i) ; Molecular and cellular basis of Shigella infections (ii)
Pam Small (Knoxville, الولايات المتحدة الأمريكية)
What can we learn from genomics about virulence in Mycobacteria species (i); Lipid-mediated virulence in Mycobacterial pathogens; macrolides polyketides and beyond (ii)
Arturo Zychlinsky (نيويورك, الولايات المتحدة الأمريكية)
Is there a physiological role for apoptosis in bacterial pathogenesis ? (i); Innate immunity in bacterial infections (ii)
Participants 2002
David Ackerley (Stanford, الولايات المتحدة الأمريكية), Sarojini Adusumilli (Knoxville, الولايات المتحدة الأمريكية), Irini Lazou Ahr?ن (Malm?, السويد), Ana Maria Alonso Santos (Cantoblanco-Madrid, إسبانيا); Alexander Avsyuk (Moscow, روسيا); Stina Berglund (Umea, السويد); Juan Pablo Bifani (Lille, فرنسا); Eva Bjur (Stockholm, السويد); Igor Brodsky (Stanford, الولايات المتحدة الأمريكية); Didier Cabanes (Paris, فرنسا); Barbara Capecchi (Siena, إيطاليا); Anna Carle (Munich, ألمانيا); Fredric Carlsson (Lund, السويد); Ronan Carroll (Dublin, Ireland); Claire Checroun (Toulouse, فرنسا ); Rebecca Jane Critchley (لندن, المملكة المتحدة); Daniele Dessi (Sassari, إيطاليا); Gustavo Dominguez Bernal (Cantoblanco-Madrid, إسبانيا); Isabel Eloi Marcelino (Oeiras, Portugal); Lisa Friedman (Boston, الولايات المتحدة الأمريكية); Diana Goldenberg (Ramat Aviv, Israel ); Ernesto Gonzalez de Valdivia (Stockholm, السويد); Marie Gottar (Strasbourg, فرنسا); Edith Gouin (Paris, فرنسا); Julien Goure (Grenoble, فرنسا); Helga Gressmann (Berlin, ألمانيا); Cyril Hamiaux (Groningen, The Netherlands); Katherine Hisert (نيويورك, الولايات المتحدة الأمريكية); Christopher Hoppner (Munich, ألمانيا); Ofir Ilan (Jerusalem, Israel); Vanesa Ivetic (Zagreb, Crotia); Harry J?rvel?inen (Berlin, ألمانيا); Mariluise Kirchner (Berlin, ألمانيا); Kaoru Komoriya (Oxford, المملكة المتحدة ); Natalia A. Kozak (الملائكة, الولايات المتحدة الأمريكية); Xin-He Lai (Umea, السويد); Maria Carmela Latella (Roma, إيطاليا); Mirjana Macvanin (Uppsala, السويد); Lena Mogemark (Umea, السويد); Daphna Mokady (Ramat Aviv, Israel); Ernesto J. Munoz-Elias (نيويورك, الولايات المتحدة الأمريكية); Eike Niehus (دبليو?rzburg, ألمانيا); Maria Jos? Oliveira (Ghent, بلجيكا); Francesca Pacello (Roma, إيطاليا); Effrosyni Papanikou (Crete, اليونان); Suzana Pinto Salcedo (لندن, المملكة المتحدة); Helmy Rachman (Berlin, ألمانيا); ب?rbel Raupach (Berlin, ألمانيا); Jean-Marc Reyrat (Paris, فرنسا); Federica Ribacchi (Roma, إيطاليا); Lars Roese (Berlin, ألمانيا); Piklu Roy Chowdhury (Christchurch, نيوزيلندا); Daniela Santapaola (Roma, إيطاليا ); Anja Seubert (Basel, سويسرا); Marcela Simsova (Prague, Czech Republic); Carlos Yesid Soto Ospina (Zaragoza, إسبانيا); Sandra Sousa (Pari, فرنسا); Kathryn E. Stockbauer (الملائكة, الولايات المتحدة الأمريكية); Charlotta Sundin (Umea, السويد); Neil Surana (Saint-Louis, الولايات المتحدة الأمريكية); Damini Tapadar (Muenster, ألمانيا); Alejandro Toledo Arana (Pamplona, Navarra, إسبانيا); Elisabeth Torstensson (Stockholm, السويد); Sara Travaglione (Roma, إيطاليا); Andr? Van Eerde (Groningen, The Netherlands); Tanay Veremeiko (Novosibirsk, روسيا); Nicolas Vodovar (Gif sur Yvette, فرنسا); Su-Yan Wang (Umea, السويد); David S. Weiss (Berlin, ألمانيا); Hanne C. Winther-Larsen (Oslo, Norway); Chen Yona (Jerusalem, Israel); Ming Yuan (Umea, السويد); Maria Mercedes Zambrano (Bogota, Colombia).
SPETSES 2003
أغسطس 29 to September 8
MOLECULAR MECHANISMS IN HOMEOSTASIS AND DISEASE
Organizers: Peter Herrlich, Jena; Herbert J?ckle, ز?ttingen; Horst Feldmann, م?nchen; Martin Blum, Stuttgart-Hohenheim; Peter Angel, Heidelberg, Statis Gonos, أثينا.
Topics:
(1) Sources of dysfunction of cellular and organismic processes
(2) Embryonic development and tissue remodelling
(3) Molecular mechanisms of disease (myeloid and bone diseases; reperfusion syndrome; parasitic diseases; human retrovirus-induced diseases; الأمراض العصبية; prion diseases; cancer including immunoevasion, metastatic mechanisms, early dissemination, drug resistance).
Lecturers and Lectures:
| Aguzzi, Adriano (Zurich) | Pathogenesis of prion diseases: mouse models |
| Angel, Peter (Heidelberg) | Wound healing and skin remodelling |
| Blum, Martin (Hohenheim) | Pattern formation in early embryonic development (i); Establishment of left-right asymmetry in vertebrates (ii) |
| Borst, Piet (Amsterdam) | Mechanisms of antigenic variation in parasites (i); Drug transporters in health and disease (ii) |
| Christofori, Gerhard (Basel) | Multistage tumorigenesis 1. Early events: proliferation and survival; 2. Late events: tumor angiogenesis and progression to malignancy |
| Clevers, Hans (Utrecht) | Patterning of the colon epithelium (i); Colon Differentiation and Colon Cancer (ii) |
| Feldmann, Horst (م?nchen) | Programmed proteolysis |
| Gasser, Susan (Geneva) | Chromatin dynamics in the interphase nucleus (i); DNA replication checkpoints and what happens when forks stall (ii) |
| Gonos, Efstathios (أثينا) | Mechanisms of ageing |
| Haass, Christian (م?nchen) | Neurodegenerative diseases (i); مرض الزهايمر (ii) |
| Herrlich, Peter (Jena) | A human disease defective in a novel step of signal transduction: a regulatory role for the link between actin cytoskeleton and plasma membrane |
| ح?rz, Wolfram (م?nchen) | Chromatin structure (i); Chromatin in transcriptional regulation (ii) |
| Karin, Michael (La Jolla) | The IkB Kinase (IKK) – A Signaling Machine and its Role in Innate and Adaptive Immunity (i); The role of IKK and NF-kB in skin development and pathology vertebrates (ii) |
| Klobeck, Hans-Gustav (م?nchen) | Activation of immunoglobulin gene loci during B cell development |
| Kr?usslich, Hans-Georg (Heidelberg) | Retrovirus-induced disease (i); Virus assembly and maturation (ii) |
| ل?hrmann, Reinhard (ز?ttingen) | The RNA splicing machinery; alternative and aberrant splicing (i and ii) |
| Niehrs, Christof (Heidelberg) | Organ development and organizer centers in vertebrates (i and ii) |
| Schibler, Ueli (Geneva) | Molecular biology and physiology of circadian rhythms |
| Simons, Kai (Dresden) | Intracellular protein transport (i); Lipid rafts and cell polarity (ii) |
| Ulrich, Axel (Martinsried) | Crosstalk in the cellular communication network: intervention in cancer progression (i); Signaling pathways as targets for therapeutic intervention in cancer progression (ii) |
| Verma, Inder (La Jolla) | BRCA1/2 (i); العلاج الجيني (ii) |
| Wagner, Erwin F. (Vienna) | Mouse models for human disease (i); Myeloid and Bone diseases (ii) |
| Weissmann, Charles (لندن) | Prion diseases in men |
| Werb, Zena (سان فرانسيسكو) | Remodelling of the cellular microenvironment (i); Animal models with metalloprotease deficiencies (ii) |
Participants:
Abakushin, Dmitri, Obninsk; Alimohammadi, Mohammad, Uppsala; Anders, Lars, Martinsried; Antoszczyk, Slawomir, Lodz; Appel, Thomas, IMB Jena; Araujo, Ines, Coimbra; Baccarini, Sara, Roma; Bespalov, Igor, Moscow; Bidzhieva, Bella, Mytishy; Brichkina, Anna, شارع. Petersburg; Cardoso, Carla, Coimbra; Deas, Emma, لندن; Deissler, Kirsten, Hohenheim; Dostert, Anja, Frankfurt; Ducasse, Miryam, Frankfurt; Fazi, Barbara, Rome; Federova, Olga, Moscow; Fern?ndez Lloris, Raquel, برشلونة; Ferraro, Elisabetta, Rome; Fj?llman, Ann, ETH Z?rich; Fleishman, Darya, Moscow; Gela, Anna, Karlsruhe; Giacinta, Cristina, Roma; Gil, Joana, Coimbra; Gu, Ven Li, Bonn; Gulati, Pawan, Karlsruhe; Heikenw?lder, Mathias, ز?rich; Heilbock, Christine, Karlsruhe; Hertl, Christina, م?nchen; Horvath, Bela, Budapest; Hoya-Arias, Ruben, Gent; Illarionova, Anna, Moscow; Isamberth, Nicolas,; Ivanova, Nevyana, Sofia; Jensen, Jan. م. , UCHSC; Kaganski, Alexander, شارع. Petersburg; Karcher, Christina, Hohenheim; Khodosevich, Konstantin, Moscow; Kie?lich, Almut, Jena; Kiialainen, Anna Karoliina, Helsinki; Kireev, Roman, Saratov; Klein , Isabella, Budapest; Klochkov, Denis, Moscow; Kohli, Bernhard, Zurich; Kolesnikova, Olga, Moscow; Koriakina, Janna, Dniepropetrovsk; Koricanac, Lela, Belgrade; Krasnobryzha, Ievgenia, كييف; Kren, Angelika, Basel; Krick, Stefanie, Giessen; Kryndushkin, Dmitrij, Moscow; Lalle, Marco, Rome; Lombardo, Marco, Rome; Matthiesen, Sonja, Bonn; McKintosh, Edward, لندن; Michelson, Piret, Tallin; Misyurina, Olga, Gamaley; Mladenovic, Aleksandra, Belgrade; م?ll, Kaidi, Tartu; م?ller, Regina; Ndlovu, Matladi, Gent; Njunkova, Olga, Tallinn; Okutuku, Burku, Izmir; Oliveira, Carla, Porto; Oliveira Martins, Maria T., Coimbra; Parlato, Rosanna, Heidelberg; Perovic, Milka, Belgrade; Petrenjov, Daniil, Minsk; Piltti, Katja, Helsinki; Pondiki, Stavroula, أثينا; ص?ntynen, Nora Maria, Helsinki; Pripuzova, Natalia, Moscow; Pustovidko, Antonina, Moscow; Rafikova, Elya, Moscow; Raicevic, Nevena, Belgrade; Reichwald, Kathrin, Jena; Reinke, Hans, م?nchen; Rottenberg, Sven, Bern; Rotz, von, Ruth, Zurich; Ruschel, Anja, Martinsried; Sander, Veronika, Salzburg; Schaper, Manuela, Bern; Semenova, Elena, Novosibirsk; Shkundina, Irina, Moscow; Shtam, Tatjana, شارع. Petersburg;Sperka, Tobias, Karlsruhe; Stamatakis, Antonios, أثينا; Stamenkovic, Kristina, Nis; Stoebe, Petra, Stuttgart; Tamkovich, Svetlana, Novosibirsk; Telegina, Ekatarina, Pushchino; Terekhova, Alena, Obninsk; Tomas, Antonia, Madrid; Tothova, Jana, Padova; Tschoep, Katrin, Leipzig; Tsruya, Rachel, Rehovot; Vallabhuparapu, Sivakumar, Karlsruhe; Vereschagina, Anna, Obninsk; Vicente, Almeida, Sandra, Coimbra; Xuan Li, Xuan, Birmingham; Yilmaz, Buket, Bilkent, Ankara; Y?lmeztepe, Arzu, Uluda.
SPETSES 2005
سبتمبر 5 ل 15
PROTEIN MISFOLDING, PROTEIN MODIFICATION AND AGE-RELATED DISEASES
Organizers: Alan R. Fersht (المملكة المتحدة) (chairman), Brian F.C. Clark (Denmark), Efstathios Gonos (اليونان), Daniela Rhodes (المملكة المتحدة), Mathias Uhlen (السويد)
Lecturers and Lectures:
| Wolfgang Baumeister (MPI Martinsried, ألمانيا) | (i) Cryoelectron tomography: why and how it is done and some state-of-the-art applications; (ii) Cryoelectron tomography: towards a macromolecular atlas of the cell |
| Vilhelm Bohr (NIH Baltimore, الولايات المتحدة الأمريكية) | (i) DNA damage and repair; (ii) DNA repair deficiencies in human premature aging |
| Judith Campisi (Berkeley, الولايات المتحدة الأمريكية) | (i) Cellular and molecular basis of aging; (ii) DNA damage and senescence |
| Aaron Ciechanover (Technicon, Haifa, Israel) | (i) Intracellular protein degradation: historical perspectives; (ii) N-terminal ubiquitination: not such rare modification anymore? |
| Brian Clark (Aarhus, Denmark) | Synthesis, البروتينات, modification and aging |
| Jane Clarke (Cambridge, المملكة المتحدة) | (i) Single-molecule studies of proteins; (ii) Investigating the complex unfolding landscapes of an elastic protein |
| Valerie Daggett (Seattle WA, الولايات المتحدة الأمريكية) | (i) Fundamentals of Molecular dynamics simulations and their application to protein folding; (ii) Investigation of amyloidogenic conformational changes with molecular dynamics simulations |
| Chris Dobson (Oxford, المملكة المتحدة) | (i) Protein misfolding and amyloid disease; (ii) Opportunities for therapeutic intervention in amyloid disorders |
| Rosario Fernandez-Fernandez (MRC Cambridge, المملكة المتحدة) | (i) Cancer overview; (ii) p53 tumour suppressor network |
| Alan Fersht (Cambridge, المملكة المتحدة) | (i) Fundamentals of protein folding and misfolding; (ii)Protein instability and cancer |
| Stathis Gonos (أثينا, اليونان) | (i) Clusterin/apolipoprotein J is a novel biomarker of senescence that regulates cellular growth and suppresses apoptosis; (ii) Proteasome function during human aging |
| Thomas Jenuwein (IMP Vienna, Austria) | (i) The epigenome in the context of the post-genomic era; (ii) The profile of repeat-associated histone lysine methylation states in the mouse epigenome |
| Daniela Rhodes (MRC Cambridge, المملكة المتحدة) | (i) Telomere structure; (ii) Towards the structure of the “30nm” chromatin fibre |
| Peter Roepstorff (Odense, Denmark) | (i) Application of mass spectrometry in proteomics; (ii) Mass spectrometry in proteomics: assignment of post translational modofications |
| George Thireos (IMBB-FORTH Heraklion, اليونان) | (i) Life according to GCN4; (ii) Transcriptional activation: many different orchestrations of the same theme |
| Mathias Uhlen (KTH Stockholm, السويد) | (i) Antibody-based proteomics; (ii) A human protein atlas for tissue profiles |
Participants:
Christian Beyschau Andersen (Novo Nordisk, Bagsvaerd,DK);Valerie Anderson (Ithaca, NY);Hwee Ching Ang (Cambridge,المملكة المتحدة);Rajiv Vaid Bassaiawmoit (Aalborg, DK); Carlos Walter Bertoncini (MPI Goettingen, د);Kate Billings (Cambridge, المملكة المتحدة); Alessandro Borgia (Roma,IT); Milica Bozic (Belgrade, YU); Iva Hafner Bratkovic (Ljubljana, SO); Martina Chang (Vienna, AU); Niki Chondrogianni (أثينا, GR); Elena Cipollini (Bologna, IT); Antonija Cvitkovic (MPI Martinsried, د); Taru Deva (Aalborg, DK); Maria Dontsova (Pushchino, RU); Regina Gonzales Dosal (Aarhus, DK); Elisa Fabiani (Grenoble, F); Kristoffer Famm(Cambridge, المملكة المتحدة); Ioannis Filippis (MPI Berlin, د); Matthias Futschik (Berlin, د); Silva Giannini (Cambridge, المملكة المتحدة); Sharon Gilead (Tel Aviv, IL); Charles Grummit (MRC Cambridge, المملكة المتحدة); Britta H?hn (Berlin, د); Wolfgang Hoyer (MPI Goettingen, د); David Huang (Montreal, كاليفورنيا); Dmitry Ivankov (Pushchino, RU); Paulina Izewska (Lausanne, CH); Kadri Janikson (Tartu, ES); Thomas J?rgensen (Odense, DK); Sviatlana Kananovich(Minsk, Belarus); Alexej Kedrov (Dresden, د); Alexandra Kienast (Heidelberg, د); Mehmet Akif Kilic (Antaly, TU); Mariya Kordysh (كييف, Ukraina); Trine Rennebod Larsen (Odense, DK); Stina Lindman (Lund, SE); Wheaton Little (MRC Cambridge, المملكة المتحدة); Joao Pedro Lopes (Coimbra, PT); Mantas Malisauskas (Umea, SE); Jia Mi (Uppsala, SE); Sanne Nabuurs (Wageningen, NL); Giovanna Navarra (Palermo, IT); Lise Nesgaard (Aalborg, DK); Candy Wai-Yan Ng(Cambridge, المملكة المتحدة); Adrian Nickson (Cambridge, المملكة المتحدة); ?zen ?senzoy (Balekizir, TU); Jadwiga Para (Lodz, PL);Aviv Paz (Rehovot, IL); Sergio Perez (Bilbao, ه); Erez Podoly (Jerusalem, IL); Johan Rockberg (Stockholm, SE); Anna Rutkowska (Heidelberg, د); Lu Sang (Aarhus, DK); ك. Tanuj Sapra (Dresden, د); ز?ن?l Seyit (MPI Martinsried, د); Irina Shkundina (Moscow, RU); Anastasia Shorina (Novgorod, RU); Christina Soromani (Cambridge, المملكة المتحدة); Johanna Steen (Stockholm, SE); Olga Szczepankiewicz (Lund, SE); Karin Tamm (Tallin, ES); Srpil Tanrecerdi(Izmir, TU); Henning Tidow (Cambridge, المملكة المتحدة); Federico Torta (Parma, IT); Jade Huong Tran (Cambridge, المملكة المتحدة); Morten Beck Trelle (Odense, DK); Ioannis P. Trougakos (أثينا, GR); Murali Karthick Vadivelu (MRC Cambridge, المملكة المتحدة);Martijn van Raaij (Enschede, NL); Lisette Verhoef (Stockholm, SE);Valeria Vetri (Palermo, IT); Catherine Worth (Cambridge, المملكة المتحدة); Wei-Feng Xue (Lund, SE); Hui Yan (Manchester, المملكة المتحدة); Konstantin B Yenkoyan (Yerevan, Armenia); Daphna Zaaroor (Haifa, IL); Evgeniy Zadorin (كييف, Ukraina); Giuliano Zanchetta (Segrate, IT); Tzviya Zeev-ben-Mordehai (Rehovot, IL).
SPETSES 2006
سبتمبر 5 ل 15
Molecular Basis of Bacterial Virulence and Survival within Infected Hosts and in the Environment
Organizers: Pascale Cossart (Institut Pasteur, فرنسا); Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية)
Lecturers and Lectures
General Lectures
Julian Davies (University of British Columbia, كندا)
What is an antibiotic ? Discovery, mode of action, biosynthesis, environmental importance
Philippe Sansonetti (Institut Pasteur, فرنسا)
What makes a pathogen, what makes a commensal, at mucosals surfaces ?
Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية)
Exploring microbial diversity
Invasive Bacteria
David Holden (Imperial College, England)
Methods to study Salmonella virulence
Pascale Cossart (Institut Pasteur, فرنسا)
Listeria invasion : from cell biology to pathogenesis
Biodiversity in bacterial pathogens
Pam Small (University of Tenessee, الولايات المتحدة الأمريكية)
Environmental pathogens… what are they, how do you find them, how do they “emerge” and what do they do ?
Jeff Miller (University of California Los Angeles, الولايات المتحدة الأمريكية)
The generation of diversity as a driving force in host-parasite interactions
Intracellular life of bacterial pathogens
David Holden (Imperial College, England)
Intracellular activities of Salmonella
Edgardo Moreno (Universidad Nacional, Costa Rica)
Intacellular life of and death of Brucella
Pascale Cossart (Institut Pasteur, فرنسا)
Actin-based motility of intracellular pathogens
Genetics and genomics
Stephen Lory (Harvard Medical School, الولايات المتحدة الأمريكية)
Genome-wide approaches towards understanding bacterial virulence
Val?rie Mizrahi (University of the Witwatersrand and National Health, South Africa)
The development and application of genetic tools for investigating pathogenesis mechanisms of Mycobacterium tuberculosis
Secretion I
Tony Pugsley (Institut Pasteur, فرنسا)
Putting proteins in their places in microbial cells
Guy Cornelis (Biozentrum der Univerist?t Basel, سويسرا)
The Yersinia Ysc=Yop type III secretion system – Part I : the apparatus
Extracellular bacteria
Gunnar Lindhal (Lund University, السويد)
How streptococcus pyogenes establishes an infection and interacts with the immune system of the host
Patrice Boquet (Facult? de M?decine de Nice, فرنسا)
General Cellular and molecular mechanisms of bacterial toxins
Regulation
Jeff Miller (University of California Los Angeles, الولايات المتحدة الأمريكية)
Signaling networks and the regulation of bacterial pathogenesis
Stephen Lory (Harvard Medical School)
Enhancement of bacterial virulence by horizontal gene transfer and pathoadaptative mutations
Secretion II
Guy Cornelis (Biozentrum der Universit?t Basel, سويسرا)
The Yersinia Ysc-Yop type III secretion system – Part II : the effectors
Tony Pugsley (Institut Pasteur, فرنسا)
Multi-component bacterial cell envelope motors
Immunity / Inflammation I
Philippe Sansonetti (Institut Pasteur, فرنسا)
Invasion and inflammatory destruction of the intestinal epithelium by Shigella
Arturo Zychlinsky (Max Planck Instit?t f?r Infektionsbiologie, ألمانيا)
Innate Immunity I : sensing bacteria
Immunity / Inflammation II
Gunnar Lindhal (Lund University, السويد)
Antigenic variation – streptococcal M protein as a model system
Pam Small (University of Tenessee, الولايات المتحدة الأمريكية)
Macrolide-mediated virulence in mycobacterial pathogens
Immunity / Inflammation III
Arturo Zychlinsky (Max Planck Instit?t f?r Infektionsbiologie, ألمانيا)
Innate Immunity II : the effectors
Edgardo Moreno (Universidad Nacional, Costa Rica)
How Brucella organisms evade proinflammatory responses and generate chronic infections
Secretion III
Patrice Boquet (Facult? de M?decine de Nice, فرنسا)
Mitochondria as new preys for bacteria: the Helicobacter pylori vacA toxin model
Genome evolution
Val?rie Mizrahi (University of the Witwatersrand and National Health, South Africa)
Mechanisms of genetic adaptation and genome evolution in mycobacteria
Julian Davies (University of British Columbia, كندا)
Antibiotics II : resistance, mechanisms, origins and evolution, solutions
Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية)
Bacteria as multicellular organisms
Participants:
Ackermann, Nikolaus, Munich DE; Baczynska, Agata, Aarhus DK; Barquero, Elias, Madrid E; Beiter, Katharina, Stockholm S; Biedzka-Sarek, Marta, Helsinki FI; Boncompain, Gaelle, Paris F; ب?ttcher, Jan Peter, Berlin DE; BRAWN, Lindsey, Cambridge UK; Brotcke, Anna, Stanford USA; BUSS, Chrisoph, م?nster DE; Cappon, Andrea, Padua I; Charova, Spyridoula, Crete GR; Ciocchini, Andres, Madrid E; Degtyar, Elena, Tel Aviv IR; Disson, Olivier, Paris F; Eilers, Bj?rn, Berlin DE; Elazar, Sharon, Jerusalem IR; ESSID, Miriam, Geneva CH; Fevre, Cindy, Paris F; Fuchs, Tobias, Berlin DE; Hagman, Arne, Paris F; HAIKKO, Johanna, Helsinki F; Hamon, م?lanie, Paris F; Hejnova, Jana, Prag CZ; Hodak, ح?l?ne, Lille F; Jaumouill?, Valentin, Paris F; Jelsback, Lotte, Copenhagen DK; JENNER, Dominic, المملكة المتحدة; Jonas, Kristina, Stockholm S; Jude, Brooke A., Dartmouth UK; Konradt, Christoph, Paris F; Kuijl, Coen, Amstserdam NL; KUMAR, Anil, Dehli IN; KUMAR, Santosh, CDFD IN; Lee, Baoleri, DK; Mally, Manuela, Basel CH; MANCEK KEBER, Mateja, Ljubljana SLO; Marin Munoz, Elvira, CSIC E; Marlow, Victoria, Edinburgh UK; Monk, Ian, Cork UK; Monson, Rita, Cambridge UK; MOSI, Lydia, Tenesse USA; Mueller, Catherine, Basel CH; Nagai, Takeshi, Tokyo JP; Nehme, Nadine, Strasbourg F; Nogueira, Patricia, CEPEM BR; Odendall, Charlotte, London UK; Panina, Ekaterina, Los Angeles USA; Papatheodorou, Panagiotis, Hohenheim DE; Persson, Jenny, Lund S; Poyraz, Omer, Berlin DE; Puhar, Andrea, Padua I; Ramos Vivas, Jos?, Paris F; Ramsden, Amy, London UK; Rasmussen, Louise Caroe Vohlander, Aarhus DK; Raupach, ب?rbel, Berlin DE; Reig, Nuria, Geneva CH; Rosini, Roberto, Chiron; Ruer, س?gol?ne, CNRS F; Sakugari, Yumiko, DK; Santi , Isabella, IRIS, Chiron; Scavone, Paula, IIBCE UY; Scherr, Nicole, Basel CH; Schneider, Muriel, London UK; Sieira , Rodrigo, UNSAM AR; Simeone, Roxane, CNRS F; Suzuki, Masato, Tokyo JP; Van der Meer, Ynske, Utrecht University; Vergara, Marta, CSIC E; Viklund, Ing-Marie, Stockholm S; VILLWOCK, Andrea, دبليو?rzburg DE; VIVES FLOREZ, Martha, Universidad de los Andes CO; Vlisidou, Isabella, Bath UK; Vogt, Guillaume, ح?pital Necker F; Warner, Digby, MRC/NHLS/WITS ZA; Wartha, Florian, Stockholm S; WATSON, Robert, Bath UK; Wladyka, Benedykt, Jagiellonian University PL; Yim, Grace, British Columbia CA; ZAVIYALOV, Andrey, CNRS FI.
SPETSES 2007
أغسطس 31 – سبتمبر 9
Molecular Mechanisms of Regeneration
Organizers: Peter Angel (Heidelberg), Horst Feldmann (Munich), Peter Herrlich (Jena) chairman, Herbert J?ckle (ز?ttingen), Benjamin Kaupp (J?lich), Erwin Wagner (Vienna)
Lecturers and Lectures
أ. Basic Cell Biology
Signal Transduction
Peter Herrlich (Jena)
Regulation of signal transduction
Axel Behrens (لندن)
Identification of coactivators linking the AP-1 transcription factor to growth factor and DNA damage signaling
Ueli Schibler (Geneva)
The circadian timing system: a web of cell-autonomous oscillations
Protein Folding and Processing
Walter Birchmeier (Berlin)
Wnt/beta-catenin signalling
Christof Niehrs (Heidelberg)
Wnt signalling
Ronald P. ك?hnlein (ز?ttingen)
Energy homeostasis in flies
Bernd Bukau (Heidelberg)
Regeneration of proteins by molecular chaperones
علم الوراثة اللاجينية
Peter Becker (Munich)
Chromatin dynamics: ATP-dependent nucleosome remodelling and beyond
Konrad Hochedlinger (Harvard)
Transcription factor induced epigenetic programming
Peter Becker (Munich)
Dosage compensation in Drosophila: vital fine-tuning of transcription
Signal Transduction and Cancer
Michael Karin (La Jolla)
The IKK complex: providing a link between inflammation and cancer (two lectures)
ب. Stem Cell Biology
Spermatogenesis and planarian regeneration
Benjamin Kaupp (J?lich)
Ca2+ oscillations and chemotactic signaling in sperm
Aziz Aboobaker (Nottingham)
(i) An introduction to the planarian system for regeneration and stem cell research
(ii) Positional signalling and remodelling on planarians
Christof Niehrs (Heidelberg)
DNA demethylation, DNA repair and pluripotency
Embryonic Stem Cells
Gordon Keller (نيويورك)
(i) Lineage specific differentiation of embryonic stem cells
(ii) Organ regeneration
Konrad Hochedlinger (Harvard)
ES cell biology
Cancer Stem Cells
Eric Lechman (Toronto)
(i) Stem cell and leukemic stem cell concepts
(ii) miRNA in leukemic stem cell biology
Piet Borst (Amsterdam)
(i) Mechanisms of drug resistance in tumors: the role of apoptosis resistance and of tumor stem cells
(ii) DNA repair and cancer chemotherapy
Adult Stem Cells
Ueli Schibler (Geneva)
Outputs of the circadian clock: from xenobiotic detoxification to liver regeneration
Maria Sibilia (Vienna)
EFGR signalling in development, regeneration and cancer
Andreas Trumpp (Epalinges)
(i) The role of Myc in stem cells during dvelopment, homeostasis and disease
(ii) Dormant and activated stem cells during homeostasis injury and cancer
ج. Organogenesis and Organ Restoration
Thomas Jenuwein (Vienna)
Epigenetic control by histone methylation
Leonhard Rudolph (Hannover)
Telomere dysfunction induces cell intrinsic checkpoints and environmental alterations limiting cell function
Erwin Wagner (Vienna)
(i) Liver regeneration, inflammation and liver cancer: functions of Jun/AP-1 and JNK/p38 kinases
(ii) Bone and skin dvelopment controlled by AP-1 (Fos/Jun)
Thomas Braun (Bad Nauheim)
Mechanisms of striated muscle regeneration: stability of lineage decisions in mesodermal derivatives
Carmen Birchmeier (Berlin)
The c-met receptor functions in adult regeneration of rat liver and skin
J?rg Huelsken (Epalinges)
Cancer stem cell maintenance in the skin is dependent on beta-catenin signalling
د. Neuronal Stem Cells
Axel Behrens (Nottingham)
Mechanisms of transcriptional regulation during neurodegeneration and cancer
Carmen Birchmeier (Berlin)
Muscle progenitors and satellite cells
Wieland Huttner (Dresden)
The cell biology of neural stem and progenitor cells:
(i) Symmetric versus asymmetric divisions
(ii) Molecular mechanisms
ه. Ageing
Thomas Braun (Bad Nauheim)
How do hearts cope with ageing and stress? The role of sirtuin longevity molecules and oxidative stress
Peter Herrlich (Jena)
Introduction into molecular mechanisms of ageing: a new vertebrate ageing model
Participants:
Abranches, Elsa (Lisbon); Alexandrova, Svetlana (Moscow); Alpern, Danil (Moscow); Andersin, Temu (Geneva); Araujo, Ines (Coimbra); Archacka, Karolina (Warsaw); Arends, Brigitte (Utrecht); Baptista, Pedro Miguel (Wake Forest); Blassberg, Robert (لندن); Boehnke, Karsten (Heidelberg); Boros, Katalin (Manchester); Buhl, Sandra (Bonn); Carreira, Bruno (Coimbra); Centanin, Lazaro (Heidelberg); Chioni, Athina-Myrto (Barts); Cizkova, Dana (Prague); Costa Silva Alvaro, Ana Rita (Coimbra); Darr, Henia (Jerusalem); Denzel, Martin (La Jolla); Diaz Garcia, Sandra (Madrid); Diefenbacher, Markus (Karlsruhe); Ditadi, Andrea (Padua); Durchdewald, Moritz (Heidelberg); Dvinge, Heidi (Cambridge); Ferrer Vaquer, Anna (Freiburg); Frade Marquez, Maria (Coimbra); ز?rm?س, Uzay (Istanbul); Gorsic, Masa (Ljubljana); Grinevich, Yekatarina (Almaty); Harasim, Thomas (Martinsried); Hefferman, Theresa (Dublin); Heidemann, Martin (Munich); Henriques Oliveira, Ana Catarina (Coimbra); Illing, Anett (Jena); Jurisch, Natalie (Heidelberg); Kajahn, Jennifer (ل?beck); ك?nel, Philipp (Bern); Kapralova, Irina (Moscow); Khatuntseva, Svetlana (Moscow); Korolija, Marina ( Zagreb); Kovalenko, Oksana (كييف); Kozlova, Alyona (Moscow); Kragl, Martin (Dresden); Krasteva, Natalia (Sofia); Kruse, Julia (Bad Nauheim); Le Martelot, Gwendal (Geneva); Martin-Duque, Pilar (Madrid); Mauricio de Sousa, Sara Cristina (Oeiras); Merkel, Ulrike (Jena); Miroshnychenko, Daria (كييف); Mocan, Elena (Moldova); Nacu, Eugen (Dresden); Nemeth, Andrea (Budapest); Otto, Anthony (Reading); Papadopoulos, Dimitrios (Basle); Pelucchi, Paride (Segrate); Perepelyuk, Maryna (كييف); Petrova, Rushana (Moscow); Rosa da Silva, Ana Cristina (Coimbra); Saini, Camille (Geneva); Sanzone, Sveva (Segrate); Scheuermann, Johanna (Heidelberg); Sch?ntaler, Helia (Vienna); Schotanus, Baukje (Utrecht); Schroeder, Arnold (Freiburg); Schwamborn, Jens (Vienna); Seitzer, Nina (Martinsried); Shakhbazau, Antos (Belarus); Skouloudaki, Kassiani (Freiburg); Snippert, Hugo (Utrecht); Spee, Bart (Leuven); Sroczynska, Patrycia (Manchester); Suvorava, Tatsiana (Belarus); van Wijk, Bram. (Amsterdam); Varga, Nora (Budapest); Voskanyan, Zaruhi (Erevan); Winkhaus, Friederike (J?lich); Yenkoyan, Konstantin (Erevan).
SPETSES 2008
سبتمبر 11-18
New Developments in Quantitative Molecular Bioscience
21 lecturers, 19 tutors, 120 students
Organizers: John McCarthy (UMIST Manchester; chair)
Lecturers and Lectures:
Participants:
No detailed information available
SPETSES 2009
سبتمبر 7 – 17
Proteins and Their Networks – From Specific to Global Analysis
Organizers: Alan R. Fersht (Cambridge University, المملكة المتحدة; chairman), Daniela Roberts (MRC Cambridge, المملكة المتحدة), Mathias Uhlen (Stockholm),
Administrative Co-ordinator:Paula Murphy (Cambridge, المملكة المتحدة)
Lecturers and Lectures
Ruedi Aebersold, ETH Zurich, Institute of Molecular Systems Biology, سويسرا. Protein Mapping using MS.
Protein Mapping using MS 1,2
Patrick Aloy, Institute for Research in Biomedicine, برشلونة, إسبانيا. Protein-Protein Interactions in the Cell; Structural Bioinformatics
Protein-Protein Interactions in the Cell 1, 2
Madan Babu, MRC Laboratory of Molecular Biology, Cambridge, المملكة المتحدة. Transcriptional regulatory networks
Transcriptional regulatory networks 1, 2
Wolfgang Baumeister, Max Planck Institute of Biochemistry, Department of Structural Biology, Martinsried, ألمانيا. Whole Cell Tomography
Whole Cell Tomography 1,2
Aaron Ciechanover, Department of Biochemistry, Technion-Israel Institute of Technology, Haifa, Israel. Ubiquitin Systems
Ubiquitin Systems in Biology
Jan Ellenberg, European Molecular Biology Laboratory, Heidelberg, ألمانيا. High-throughput fluorescence microscopy for systems biology
High-throughput fluorescence microscopy for systems biology 1, 2
Alan Fersht, MRC Centre for Protein Engineering and University of Cambridge, Cambridge, المملكة المتحدة. p53 Tumour Suppressor, Protein Folding
Tumour suppressor p53: from structure to drug discovery 1, 2
Joerg Hoheisel, Deutsches Krebsforschungszentrum, Heidelberg, ألمانيا. High-throughput analysis of cancers; Functional Genome Analysis
High-throughput analysis of cancers 1, 2
Batsheva Kerem, The Department of Genetics, Jerusalem, Israel. Genetics and Disease
Genetics and disease 1,2
Daniela Rhodes, MRC Laboratory of Molecular Biology, Cambridge, المملكة المتحدة. Chromatin and Telomere Structure.
Chromatin Structure
Carol Robinson, Department of Chemistry, University of Cambridge, المملكة المتحدة. Mass Spectroscopy
Mass Spectrometry of Protein Complexes 1,2
Mathias Uhlen, Department of Biotechnology, Royal Institute of Technology, Stockholm, السويد. Human Protein Atlas
Human Protein Atlas 1, 2
Participants:
Eyal Arbely, Cambridge, المملكة المتحدة; Elvan Arslan, Paris, فرنسا; Anush Bakunts, Pushchino, روسيا; Wiktor Banachewicz, Cambridge, المملكة المتحدة; Isabelle Bergiers, Louvain-la-Neuve, بلجيكا; Florian Brandt, Martinsried, ألمانيا; Tobias Brandt, Cambridge, المملكة المتحدة; Sarah Burge, Cambridge, المملكة المتحدة; Varodom Charoensawan, Cambridge, Alexander Chernorudskiy, Nizhny Novgorod, روسيا; Celestine Chi, Uppsala; Claus Christensen, Copenhagen N, Denmark; Jan van Dieck, Cambridge, المملكة المتحدة; Evgeny V. Dvoretsky, Moscow; Ksenia Egorova, Moscow; Armida Fabius, Amsterdam; Mar?a Marta Garc?a Alai, Cambridge, المملكة المتحدة;Javier Garcia, Heslington, York, المملكة المتحدة; Elizabeth M. Gardner, لندن; Shirin Dattatraya Ghodke, Aarhus, Denmark; Miriam Goyder, لندن; Giovanna Grimaldi, Chieti, إيطاليا; Felix Halbach, Martinsried, ألمانيا; Michal Harel, Rehovot, Israel; Zvi Hayouka, Jerusalem, Israel; William P. Heal, لندن; Anne HempelCambridge, المملكة المتحدة; Barbara Hjelm, Stockholm, السويد; Eva Hradetzky, Cambridge; Phillip Hundeshagen, Heidelberg, ألمانيا; Alexander Ivliev, Moscow, روسيا; Sarath Chandra Janga, Cambridge; Maria (Jensen) Andreasen, Aarhus C – Denmark; Joe Kaplinsky, لندن; Jekaterina Kazantseva, Tallinn, Estonia; Andrea Kiss, Debrecen, Hungary; Christi Laur, Tallinn, Estonia; Lina Leinartaite, Stockholm, السويد; Christian L?w, Stockholm, السويد; John L?fblom, Stockholm Sweden;Jenifer Lum, Cambridge, المملكة المتحدة; Rafal Marszalek, لندن; Gabriela Vaz Meirelles, Campinas, س?o Paulo, Brazil; Margherita Miele, لندن; David Minde, Utrecht, The Netherlands, Elizabeth Rozalia Morris,Nottingham, المملكة المتحدة; Angela Morrone, Rome, إيطاليا; Aurelio A. Moya-Garc?أ, م?laga. إسبانيا; Lavinia Nardinocchi, Rome, إيطاليا; Antonina Nakalska, Warsaw, بولندا; Johan Nilvebrant, Stockholm, السويد;Veronika Ostatn?, Brno, Czech Republic; Hanka Paulitschke, Utrecht, The Netherlands; Rafal Pawlowski, لندن, المملكة المتحدة; Lauri Peil, Tartu, Estonia; Tina Perica, Cambridge; Miriana Petrovich, Cambridge;John Phillips, لندن; Anne Pink, Tallinn, Estonia; Rosa Puca, Rome, إيطاليا; Anita Rea, Nottingham, المملكة المتحدة; Tomasz Religa, Toronto, كندا; Christiane Riedinger, Oxford, المملكة المتحدة; Johan Rockberg, Stockholm, السويد; Madeleine Ross, CambridgeM Shahar Rotem, Jerusalem, Israel; Robert Sade, Cambridge UK; Ali Salehi-Reyhani, لندن; Sara Sandin, Cambridge, المملكة المتحدة; Akuma Divine Saningong, Essen, ألمانيا; Thomas Seaby, لندن; Elena Smekalova, Moscow, روسيا; Henning Tidow Aarhus C, Denmark; Kairit Tints, Tallinn, Estonia; Jeremy Touati, Lausanne, سويسرا; Maria Angeles Vazquez Sanchez, برشلونة, إسبانيا; Maryna Veremieva, كييف , أوكرانيا; Alicja Warowicka, Poznan Poland;Konstantin Yenkoyan, Yerevan, Armenia; Maryna Zhylinskaya, Tallinn , Estonia.
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