Stem Cell Therapy as a Novel Approach for Chronic Hepatitis B
Chronic hepatitis B (慢性乙型肝炎) 是一个全球性的健康问题, affecting over 250 million people worldwide. Despite the availability of antiviral therapies, a significant proportion of patients fail to achieve sustained virological response, leading to disease progression and an increased risk of liver cirrhosis and hepatocellular carcinoma. 干细胞治疗 has emerged as a promising novel approach for CHB, offering the potential for a functional cure by targeting the underlying mechanisms of viral persistence and liver damage.
Mechanisms of Stem Cell Action in Hepatitis B Infection
Stem cells possess unique properties that make them suitable for treating CHB. These include their ability to differentiate into various cell types, 包括肝细胞, which are the primary target of hepatitis B virus (乙型肝炎病毒) 感染. Stem cells can also secrete paracrine factors that exert immunomodulatory and antiviral effects. By replacing damaged hepatocytes, 减少炎症, and inhibiting viral replication, stem cells may contribute to liver regeneration and disease resolution.
Preclinical Studies and Animal Models in Stem Cell Therapy for Hepatitis B
动物模型的临床前研究已经证明了其潜力 干细胞疗法 for CHB. 在这些研究中, stem cells have been shown to improve liver function, reduce viral load, and promote hepatocyte regeneration. 然而, the optimal stem cell source, 交货方式, and timing of intervention still need to be determined. Further research is necessary to translate these preclinical findings into successful clinical applications.
