Stem Cells CRISPR gene editing help identify therapeutic targets for neurological disorders

CRISPR-Cas9 technologies and human pluripotent stem cell technologies help to identify new therapeutic goals for neurological disorders such as schizophrenia and drug addiction.

CRISPR-Cas9 modified stem cells is a universal and high-precision gene editing technology that allows researchers to modify certain parts of the body’s genome by changing sections of the DNA sequence.

Human-associated pluripotent stem cells (iPSCs) Are a genetic research tool that can be created from adult human cells, avoiding the need to use tissue from embryos (along with relevant controversies).

Stem cells can be converted into cells of any type in the body, which allows research in several human systems. New applications of these relatively recent technologies facilitate research at the gene-specific level, creating the potential for developing new treatments.

Today’s new results show that:

Adaptation of CRISPR-Cas9 modofied stem cells technology can detect epigenetic „from“ Und „on“ signals for genes that cause cocaine dependence .
The scientists used CRISPR-Cas9 to shed light on why people with the 15q13.3 microdeletion syndrome – a rare human genetic disorder – are more likely to develop brain disorders such as Autismus-Spektrum-Störung, epilepsy and schizophrenia .

Using iPSC stem cells, researchers have developed a new model of cellular disease to investigate the neurobiological causes of schizophrenia, which are not well understood.

Other recent findings, which were discussed, show that:

UScientists have established that a specific protein produced by the Zick virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns .
„Today’s results show many of the advances we have made in the use of CRISPR-Cas9 and the human technologies of pluripotent Stammzellen and the amazing discoveries that have resulted,“.

„Neuroscientists use these new tools for gene editing and molecular tools to develop potential therapeutic goals on several disease fronts.“

Tags: addiction, Autismus, Gehirn, Cas9, cell, cocaine addiction, CRISPR, DNA, Epilepsie, gene, gene editing, genes, genetics, genetic disorder, genome, light, microcephaly, Nervensystem, Neurologie, protein, schizophrenia, Stammzellen , virus, virus of Zika

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