Azoospermia, infertility treatment by using stem cells
Azoospermia is defined as the complete lack of sperm in the ejaculate.
In humans, Azoospermia affects about 1% of the male population and may be seen in up to 20% of male infertility situations. In testicular Azoospermia the testes are abnormal, atrophic, or absent, and sperm production severely disturbed to absent.
FSH levels tend to be elevated (hypergonadotropic) as the feedback loop is interrupted. The condition is seen in 49-93% of men with Azoospermia.
The diagnosis of Azoospermia will be established on the basis of two semen analysis evaluations done at separate occasions; this will be followed by detailed history taking, physical examination and investigations. History taking will include general health, sexual health, past fertility, libido, sexual activity and previous exposure to surgery, drugs, mumps infection and irradiation.
Physical examination includes genital and local examination for detection of signs of Klinefelter syndrome, testicular atrophy, absence of vas. Investigations include serum FSH, LH, karyotyping and testosterone levels, and may include testicular biopsy or transrectal ultrasound if indicated (Low levels of LH and FSH with low or normal testosterone levels are indicative of pretesticular problems, while high levels of gonadotropins indicate testicular problems. However, often this distinction is not clear and the differentiation between obstructive versus non-obstructive Azoospermia may require a testicular biopsy).
80 000 000 ml of stem cells prepared according to GMP rules will be injected intravenously and into testis.
Expected Improvement [ Time Frame: 12-24 Weeks ]
Serum Hormonal Profile:
(elevation of testosterone levels, decreasing of FSH, LH and Prolactine Levels); Testicular Size (increased size); and Sexual Potency (increased sexual potency).
One of the most exciting potential approaches is stem cells therapy — cells that exist throughout the body and can create our components, including tissues and blood cells. That could help men who cannot produce sperm. In humans, we have data from our lab showing the creation of sperm-like cells from stem cells, a crucial step in the research.
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