Stem cell therapy holds promise for treating infection-related kidney damage, a significant health concern worldwide. This article explores the potential of stem cells in renal repair, discussing the pathogenesis of infection-related kidney damage, stem cell sources, delivery methods, preclinical and clinical studies, and future directions in stem cell-based renal regeneration.
Stem Cell Therapy for Infection-Induced Renal Impairment
Infection-related kidney damage, ranging from acute kidney injury to chronic kidney disease, poses a substantial clinical challenge. Traditional treatment options are often limited in efficacy, highlighting the need for novel therapeutic approaches. Stem cell therapy emerged as a promising strategy due to the regenerative and immunomodulatory properties of stem cells.
Pathogenesis of Infection-Related Kidney Damage
Infection-related kidney damage can result from various pathogens, including bacteria, viruses, and fungi. These pathogens invade renal parenchyma, triggering an inflammatory cascade that leads to tissue injury. Inflammatory mediators, such as cytokines and chemokines, recruit immune cells to the kidneys, causing further damage. Moreover, infection can disrupt the glomerular filtration barrier, leading to proteinuria and renal dysfunction.
