1. Infection-Related Kidney Disease: A Silent Threat
Infection-related kidney disease (IRKD) is a severe and often overlooked complication of various infections. It can lead to significant kidney damage, potentially resulting in end-stage renal disease (ESRD) and the need for dialysis or kidney transplantation. Despite its prevalence, IRKD is often underdiagnosed due to its subtle and nonspecific symptoms in the early stages.
Understanding the mechanisms underlying infection-induced kidney damage is crucial for developing effective therapeutic strategies. Infections can trigger an inflammatory cascade within the kidneys, leading to the release of cytokines and chemokines that promote the recruitment of immune cells. These immune cells can damage kidney tissue, impairing renal function. Furthermore, infections can directly infect kidney cells, causing cell death and further compromising kidney function.
2. Understanding the Mechanisms of Infection-Induced Kidney Damage
IRKD can arise from various infections, including bacterial, viral, and parasitic infections. Bacterial infections, such as pyelonephritis and urinary tract infections, are common causes of IRKD. Viral infections, such as hepatitis B and C, can also lead to kidney damage. Parasitic infections, such as malaria and schistosomiasis, can cause severe kidney injury and contribute to IRKD.
