Stem Cell Therapy for Cholestasis: نظرة عامة
Cholestasis, a condition characterized by impaired bile flow, can lead to liver damage and fibrosis. Current treatment options are limited and often ineffective. العلاج بالخلايا الجذعية has emerged as a promising approach for cholestasis treatment, offering the potential for tissue regeneration and functional restoration.
Current Challenges in Cholestasis Treatment
Conventional cholestasis treatments, such as ursodeoxycholic acid and cholestyramine, provide symptomatic relief but do not address the underlying cause. Liver transplantation is the only curative option for end-stage cholestasis, but it is limited by donor availability and the risk of complications.
Stem Cells as a Potential Therapeutic Option
تمتلك الخلايا الجذعية القدرة على التجديد الذاتي والتمايز إلى أنواع مختلفة من الخلايا. Their regenerative potential makes them an attractive therapeutic option for cholestasis, where damaged liver cells can be replaced or repaired. Stem cells can be derived from various sources, بما في ذلك نخاع العظام, الأنسجة الدهنية, ودم الحبل السري.
Types of Stem Cells for Cholestasis Treatment
Different types of stem cells have been investigated for cholestasis treatment. الخلايا الجذعية الوسيطة (اللجان الدائمة) are multipotent cells that can differentiate into various cell types, including liver cells. Hepatic stem cells (HSCs) are liver-specific stem cells that can regenerate liver tissue. الخلايا الجذعية الجنينية (المجالس الاقتصادية والاجتماعية) are pluripotent cells that can differentiate into any cell type in the body.
