Spetses Summer Schools are internationally recognized advanced training programs that bring together leading scientists, الباحثين, and early-career professionals from around the world. Hosted on the Greek island of Spetses, these programs focus on cutting-edge topics in biomedicine, molecular biology, التكنولوجيا الحيوية, and interdisciplinary sciences.
The tradition of Spetses Summer Schools dates back to the 1960s and has since attracted thousands of participants, including world-renowned researchers and Nobel Prize laureates . These courses are designed to provide intensive, high-level education in rapidly evolving scientific fields, combining lectures, discussions, and hands-on learning.
اليوم, Spetses hosts a wide range of specialized programs, مشتمل:
- molecular and cell biology
- functional genomics and metabolic diseases
- redox biology and disease mechanisms
- stem cell biology and regenerative medicine
- advanced economics and data science
على سبيل المثال, ال European Summer School on Stem Cell Biology and Regenerative Medicine held in Spetses brings together leading experts in the field to explore the latest developments in cell-based therapies, تجديد الأنسجة, and biomedical innovation .
These programs are typically organized in collaboration with major scientific organizations such as FEBS, EMBO, and IUBMB, and are aimed primarily at PhD students, postdoctoral researchers, and medical professionals seeking advanced training and international collaboration.
🌍 Unique Scientific Environment
Spetses offers a unique environment for scientific exchange. The courses are held at the historic Anargyrios and Korgialenios School, a prestigious academic venue that hosts international educational programs and research meetings .
The island itself, located in the Saronic Gulf near Athens, provides a focused and distraction-free setting that encourages collaboration, networking, and idea generation .
🔬 Connection to Biotechnology and Regenerative Medicine
Many Spetses Summer Schools focus on topics directly related to modern biotechnology and regenerative medicine, مشتمل:
- cellular signaling
- genomics and molecular mechanisms
- disease modeling
- stem cell research and therapeutic applications
في أ biotechnology laboratory in Barcelona, إسبانيا, similar research directions are actively explored, وخاصة في مجال العلاج بالخلايا الجذعية. Scientists study how الخلايا الجذعية الوسيطة can be used to:
- تعديل الاستجابات المناعية
- تقليل الالتهاب
- support tissue regeneration
- improve outcomes in neurological and chronic diseases
These parallels highlight how academic training programs like Spetses Summer Schools contribute to the development of next-generation medical technologies.
🎓 Why Spetses Summer Schools Matter
Spetses Summer Schools play a critical role in:
- accelerating scientific knowledge transfer
- fostering international collaboration
- training the next generation of biomedical researchers
- bridging the gap between basic science and clinical application
They represent a key platform where new ideas in التكنولوجيا الحيوية, medicine, and data science are developed and shared.
This compilation of ‘Spetses Summer Schools’ is dedicated to Professor Dr. Marianne Grunberg-Manago, باريس. في 1996, it was 30 years since these renowned Summer Schools in Molecular and Cell Biology came into existence largely through the initiative of Mme. Grunberg-Manago. Following the first Advanced Study Institute in 1966 held on the Island of Spetsai, Summer Schools devoted to topics of current interest were organized annually. These courses have had great success over the years, because they have attracted internationally acclaimed scientists as lecturers as well as excellent student participants from all over the world. The relaxed and pleasant atmosphere always fostered fruitful discussions and social interactions between the students and the lecturers. في 2006. we can celebrate the 40th Anniversary of the Spetses Summer Schools.
The first part, up to the Summer School in 1988, has been reproduced from a similar compilation, which has been published as an Annex to the Proceedings of a NATO/FEBS Advanced Research Workshop on ‘Evolutionary Tinkering in Gene Expression’ held August 29-31, 1988 in Spetsai (اليونان) – NATO ASI Series: Life Sciences, vol. 169 (م. Grunberg-Manago, B.F.C. Clark and H.G. Zachau, eds.), Plenum Press, New York and London, 1989.
SPETSAI 1996
September 2 – September 12
MECHANISMS IN EUKARYOTIC GENE REGULATION
Organizers: ح. Feldmann (م?nchen)(chairman), A.E. Evangelopoulos (Athens), دبليو. ح?rz (م?nchen), H.-G. Klobeck (م?nchen)
Lecturers and Lectures:
Piet Borst (Amsterdam): (أنا) و (ثانيا) Molecular mechanisms of antigenic variation in African trypanosomes.
Margret Buckingham (باريس): (أنا) Myogenesis: Myogenic factors and muscle gene regulation; (ثانيا) Myogenic factors and muscle cell determination.
Horst Feldmann (م?nchen): The yeast genome project: what do we learn from a simple eukaryote?
David Glover (Dundee): (أنا) The eukaryotic cell cycle. (ثانيا) Cell cycle regulation in Drosophila.
Frank Grosveld (Rotterdam): (أنا,ثانيا) Organization and locus-specific regulation of the globin genes.
Peter Gruss (G?ttingen): (أنا) Molecular analysis of the vertebral visual system development. (ثانيا) The use of gene trap to identify mammalian developmental control genes.
Peter Herrlich (Karlsruhe): (أنا) Signal transduction to transcription factors. (ثانيا) The role of adhesion molecules in determining genetic programs.
Jonathan Hodgkin (كامبريدج): (أنا) Genomic analysis of the nematode Caenorhabditis elegans: towards the complete DNA sequence of a simple animal. (ثانيا) Sex determination and mechanisms of developmental gene control in the nematode ج. elegans.
Wolfram H?rz (م?nchen): (أنا) Regulation of gene expression by nucleosomes. (ثانيا) Mechanism of chromatin activation at the PHO5 promoter.
Herbert J?ckle (G?ttingen): (أنا) Transcription factors in Drosophila تطوير. (ثانيا) Homeotic and gap genes in Drosophila.
Fotis C. Kafatos (Heidelberg): (أنا) Multifunctional transcription factors in Drosophila development and evolution. (ثانيا) Molecular genetic studies of a major insect vector of disease, the malaria mosquito.
Michael Karin (سان دييغو): (أنا) Signal transduction from cell surface receptors to the nucleus. (ثانيا) Control of cell-type specific gene expression: the growth hormone gene and the anterior pituitary.
Hans-Gustav Klobeck (م?nchen): (أنا) و (ثانيا) Control of immunoglobulin gene assembly during B cell development.
Rudi J. Planta (Amsterdam): (أنا) Global regulators of gene expression in yeast. (ثانيا) Heterologous gene expression in yeast.
Walter Schaffner (Z?rich): (أنا) Transcriptional activation and repression at a distance. (ثانيا) MTF-1, a key factor for heavy metal-regulated gene expression in mammalian cells.
Ueli Schibler (جنيف): (أنا) Transcription activation by an RNA polymerase II holoenzyme complex. (ثانيا) PAR-family transcription factors and circadian rhythmicity
Andr? Sentenac (Gif-sur-Yvette): (أنا) و (ثانيا) Yeast polymerase III transcription: a paradigm for gene activation.
Kevin Struhl (Harvard, بوسطن): (أنا) Mechanism of transcriptional activation. (ثانيا) Global transcriptional repression mechanisms.
Inder M. Verma (سان دييغو): (أنا) Function of NF-kB/rel/I-kB proteins. (ثانيا) العلاج الجيني.
Robert Weinberg (Cambridge MA): (أنا) و (ثانيا) pRB, cyclins and control of cell proliferation.
Charles Weissmann (Zurich): (أنا) Generation of animal models of human disease: principles and methods. (ثانيا) The role of PrP in prion disease.
Alan P. Wolffe (Bethesda MD): (أنا) Histones, nucleosomes and the role of chromatin structure in transcriptional control. (ثانيا) Global control of transcription and translation during early development.
Hans G. Zachau (م?nchen): (أنا) Human and other genome projects. (ثانيا) The immunoglobulin genes and their acrobatics.
Participants:
A.Abroi (Tartu), P.Alen (Leuven), G.Alexandru (Bucuresti), E.K.Amankwah (Bergen), Nina Aro (هلسنكي), A.Atalay (Ankara), A.Bahr (Illkirch), ح. Balkan-Mergen (Ankara), U.Baron (Heidelberg), G.Baur?n (Stockholm), M.Bencina (Ljubljana), L.Bjergbaek (Aarhus), L.Bogomolnaya (Moscow), S.Borda (Szeged), A.Brehm (Heidelberg), J.Brzeski (وارسو), H.B?ning (م?nchen), M.Bullejos (Granada), R.Burchmore (Portland OR), R.Calligaris (Trieste), G.Cavalli (Heidelberg), A.Chabes (Ume?), N.Chernyaeva (Moscow), P.Cheung (Hamilton, Ontario), L.Ciapponi (Pomezia Rome), M.A.Cohen (نيويورك), N.Daly (Dublin), G.Di Matteo (Roma), M.Dimitrova (Strasbourg), T.Dincer (Ankara), G.Di Rocco (Milano), A.Echarri Aguirre (Madrid), T.Einbinder (Beer-Sheva), M.Faria (باريس), D.Fear (لندن), A.Freudenstein-Dan (Tel-Aviv), S.Friant (Strasbourg), L.Frostesj? (Umea), A.Gaal (Budapest), I.Garcia-Bassets (برشلونة), B.Gelius (Stockholm), W.G?rner (فيينا), D.Gougoumas (سالونيك), J.H. Gribnau (Rotterdam), J.Hadchouel (باريس), I.Hegyi (Z?rich), M.Hellquist (G?teborg), L.Hertel (Novara), M.Hinz (Berlin-Buch), Y. Hisatomi (Okazaki), T.Holtschke (Penzberg), أ. Ivanov (Moscow), M.Janitz (Berlin), M.C.J?rgensen (Gentofte), C.Johnston (لندن), J.Joyce (كامبريدج), D.Karandrea (Athens), Z.Karetsou (Ioannina), J.Kirfel (Freiburg), M.Kleines (ك?ln), A.Knutson (Uppsala), L.R.Kockel (Heidelberg), J.Kontaraki (Heraklion), W.Korver (Utrecht), M.Koutsourakis (Rotterdam), S.V.Kozlov (Z?rich), J.Kzhyshkowska (Moscow), M.J.Lafuente (Madrid), C.Larsson (Uppsala), B.Lenhard (Zagreb), D.Liberg (Lund), A.Lin? (Riga), S.Llanos Giron (Madrid), M.Lnenicek-Allen (Portsmouth), L.Lopez-Molina (Gen?ve), S.L?cke (Berlin), I.Mandrika (Riga), A.Moore (Edingburgh), A.M?hlethaler (Gen?ve), C.W.M?ller (Grenoble), M.Nguyen (باريس), S.J.Nielsen (Aarhus), C.O’Conallain (Dublin), P.Emanuel de Oliveira Marujo (Oeiras), M.Pap (Pecs), D.Patterton (Bethesda, دكتوراه في الطب), V Pevzner (Berlin-Buch), A.Pintzas (Athens), D.Pozo (Seville), C.Provenzano (Rome), A.Pujol (Heidelberg), A.S.Purewal (لندن), C.M.Quinn (Oxford), I.Reimann (Berlin), N.Rethmeier (Gent), A.M.Rezler (Poznan), A.Rezler (Poznan), G.Ries (Basel), D.Robyr (Bethesda, دكتوراه في الطب), O.K.Rodningen (Oslo), T.Ronni (هلسنكي), T.E.Rusten (Bergen), S.Samakoglu (Antalya), R.Santoro (Jena), U.Schwidetzky (Berlin), M.Shoresh (Tel-Aviv), E.Sigurdsson (Reykjavik), O.Simonova (Moscow), E.Smirnova (Moscow), I.Spitsyna (Dniepropetrovsk), F.Spitz (باريس), C.Springer (Erlangen), J.Svaren (شارع. لويس, شهر), G.K.Stefanakis (Athens), H.Thonberg (Stockholm), م. de Castro Tom? (Coimbra), I.Udalova (Oxford), S.Vambrie (Wien), D.J. Van Antwerp (سان دييغو, كاليفورنيا), W.Van den Berghe (Gent), T.B. van Dijk (Utrecht), ح. Van Doorninck (Rotterdam), R.Wellinger (Z?rich), C.Wood (Liverpool), A.Zacharova-Albinger (Z?rich), A.M.Zeeman (Leiden), K.Zeng (Kassel), R.Zichel (Rehovot).
SPETSES 1997
September 1 -14
BIOMOLECULAR RECOGNITION
Organizers: B.F.C. Clark (Aarhus), A.E. Evangelopoulos (Athens), A.R. Fersht (كامبريدج)
Lecturers and Lectures:
Brian Clark (Aarhus): Activation of GTP-binding proteins: translation factors. Implications of the structure of the ternary complex.
Valerie Daggett (Seattle): Molecular dynamics studies of intramolecular protein recognition: protein folding /unfolding.
Alan Fersht (كامبريدج): Protein folding in vitro: from chaperones to minichaperones.
Marianne Grunberg-Manago (باريس): RNA folding and RNA translation control.
Ulrich Hartl (نيويورك): Protein folding with molecular chaperones.
Hennie Hoogenboom (Maastricht): Phage display based tools to generate and study biomolecular interactions: Designing and optimizing phage-based strategies for generating high-affinity antibodies.
Morten Kjeldgaard (Aarhus): From crystal to model. Structure and function of the family of the G-proteins.
Peter Laing (كامبريدج): Consensus as a tool of structural inference: generation of ligand models from peptide libraries.
Dino Moras (Strasbourg): tRNA aminoacylation. The ligand binding domain of nuclear receptors: 3D structure and functional correlations.
Poul Nissen (Aarhus): RNA-protein recognition.
Martin Noble (Oxford): Protein kinases and the role of phosphorylation. Protein interactions in the regulation of the cell cycle.
Sheena Radford (Leeds): Protein folding mechanisms: recent insights using biophysical methods. Protein misfolding and amyloidosis.
Tony Rees (Bath): The design of allosteric switches in proteins. Antibodies.
Daniela Rhodes (كامبريدج): Telomeric DNA recognition. Protein-DNA recognition.
Chris Sander (كامبريدج): Mapping the protein universe.
Gottfried Schatz (Basel): Protein import into mitochondria as a paradigm of protein transport across biological membranes.
Manfred Schneider (Wuppertal): Lipases as catalysts in organic synthesis.
Gideon Schreiber (Rehovot): Mechanism of protein-protein interaction.
Tom Steitz (Yale): Structural principles of protein nucleic-acid interactions with emphasis on RNA structural diversity and recognition. DNA and RNA polymerases: structural diversity and common mechanisms.
Mathias Uhlen (Stockholm): Scaffolds for engineering novel binding sites in proteins. Affibodies – binding proteins selected from combinatorial libraries.
Eric Westhoff (Strasbourg): Tools for studying RNA structure and folding. RNA tectonics. The modular and hierarchical assembly of group I introns.
Fred Wittighofer (Dortmund): Signal transduction via small GTP-binding proteins. Ras as a paradigm: (أ) interaction with effectors, (ب) the turn-off mechanism of the molecular switch – the GTPase reaction.
Kurt W?thrich (Zurich): Macromolecular recognition studied by NMR. Prion structure and transmissible spongiform encephalopathies.
Zhaohui Xu (Yale): The crystal structure of the bacterial chaperonin complex GroEL.GroES.(ADP)7. Structure and functional studies of chaperonin-assisted protein folding.
Participants:
ك. Alexandrov (Dortmund), M.Altamirano (كامبريدج), P.Alves (Lisboa), ك. Andersson (Lund), E. Balcan (Izmir), ح. Barrios (Cuernavaca Morelos, المكسيك), ص. Beatus (Stockholm), T. Bengtson (Stockholm), ج. Berset (Bern), T.Celius (Bergen), س. Chetyrkina (Kiev), F. Christ (Giessen), G. Cingolani (Grenoble), G. Conn (Baltimore), F. Constantinesco (Gif-sur-Yvette), أ. Danielewicz (Cleveland), س. Das (New Delhi), م. Daub (Dortmund), M.C. Deller (Gif-sur-Yvette), م. Deniziak (Gif-sur-Yvette), م. Dickman (Sheffield), E. Enchev (Sofia), K.N. Engin (Istanbul), F. Guarino de Felice (Rio de Janeiro), V. De Filippis (Padova), ج. Fladeby (Bergen), P.G. Foster (سان فرانسيسكو), I. Galetich (Kharkov), أ. Gawlak (Poznan), ج. Gille (فرانكفورت), ب. Guerra (Odense), Y.V. Guervaziev (Moscow), C.S. Hamnn (Philadelphia), T. Hamelryck (Rhodes St. Genese), أ. Hendrick (Cork), I. Hoch (vienna), M.-R. Hoja (Uppsala), O. Ignatovich (كامبريدج), ك. Johansson (Uppsala), H.F. ج?rgensen (Aarhus), T. Killick (كامبريدج), G. Klein (Gdansk), أ. Kondo (طوكيو), م. Kontou (Uppsala), E.A. Kovrigina (Pushino), م. Krogsgaard (Copenhagen), B.L: Kuehl (Dundee), أ. Ladurner (كامبريدج), U. Langhorst (Rhodes St. Genese), D. Larkin (Houston), م. Laurberg (Lund), Yin-fai Lee (كامبريدج), E.V. Levsshenkova (Moscow), T. Linnemann (Dortmund), م. Macht (Konstanz), G. Malpeli (Parma), أ. Malygin (Novosibirsk), أ. Mans?n (Stockholm), I. Marchand (باريس), م. Marinou (Athens), ب. Masquida (Strasbourg), ر. McCarthy (Bath), أ. Merlin (Freiburg), E. Moreno (Madrid), O.N. Murashko (Minsk), D.A. Murtazina (Moscow), ر. Mutuberria (Maastricht), ج. Nielsen (Heidelberg), م. Ninkovic (Jena), ص. Nissen (Aarhus), س. ?nal (Izmir), أ. Palsson (Reykjavik), D. Papanastassiou (Athens), G. Patikoglou (New Haven), H.H. Petersen (Aarhus), ج. Petropoulou (Athens), ن. Polacek (فيينا), ن. Popescu (Bucuresti), F. Possmayer (باريس), E. Psichari (Athens), أ. Rak (Pushino), ح. Reiersen (Bath), L. Reynolds (Portsmouth), م. Righi (Trieste), ر. Roovers (Maastricht, ك. Sak (Tartu), ج. sauter (Strasbourg), م. Schneider (Wuppertal), أ. Serganov (Pushino), م. Shapira (Jerusalem), م. Sloma (Stockholm), ص. Stanislawski (وارسو), N.N. Starkova (Moscow), V. Subramaniam (G?ttingen), L. Supino-Rosin (Ramat-Avis), ج. Takemoto (طوكيو), ج. Tame (Heslington, York), ح. Taylor (كامبريدج), G. Tocchini-Valentini (Strasbourg), م. Tock (Leeds), ر. Toth (Debrecen), س. Townson (Manchester), T. Tsouloufis (Athens), ج. Tzagarakis-Foster (Davis CA), I.P. Uray (Devrecen), س. Ureuqui (باريس), F. Uysal (Izmir), م. Valtavaara (Oulu), D. Verhamme (Amsterdam), ج. Villa (Dortmund), T. Voronkova (Riga), ر. warth (جنيف), م. Wilcke (باريس), س. Williams (لندن), T. Wind (Aarhus), O. Yifrach (Rehovot), دبليو. Yong (aarhus), ص. Zajakins (Riga), I. Zamfir (Bucuresti), Changqi Zhu (Karlsruhe), ك. Zimna (Poznan).
SPETSES 1998
August 30 to September 12
MOLECULAR BASIS OF BACTERIAL INFECTION
Organizers: ج. Davies (Vancouver), A.E. Evangelopoulos (Athens), م. Grunberg-Manago (باريس) (Chairman)
Lecturers and Lectures:
ص. Sharp (Nottingham): (1) Microbial diversity: phylogentic studies. (2) Evolution of repetitive sequences in bacteria: ERIC sequences.
م. Radman (باريس): Control of genetic variability in bacteria: mutation, recombination, selection and speciation.
B.M?ller-Hill (Cologne): Negative control of transcription in E.coli.
س. Busby (Birmingham): (1) Positive activation of gene expression in E.coli. (2) Catabolite repression in gram-positive organisms.
م. Grunberg-Manago (باريس): Translational initiation and its control in gram-negative and gram-positive bacteria.
ج. McCarthy (Manchester): Control of translation and mRNA stability in yeast.
B.F.C. Clark (Aarhus): (1) Activation of GTP-binding proteins: translation factors. (2) Structure of the ternary complex and role of kyrromycin.
Y. Nakamura (طوكيو): Regulation of translation termination and recoding.
L. Kisselev (Moscow): Termination in eukaryotes.
ح. Feldmann (Munich): (1) Functional analysis of the yeast genome. (2) Yeast as a model system for programmed proteolysis and pathogenic fungi.
ر. Rappuoli (Siena): New vaccines.
ج. Davies (Vancouver): Antibiotics: action and resistance.
ب. Simons (لوس أنجلوس): (1) Prokaryotic mRNA decay and its regulation. (2) Antisense RNA and its control – natural and contrived.
ج. Georgopoulos (جنيف): (1) Protein folding, proteolysis and molecular chaperones. (2) Function and regulation of the heat-shock response in Escherichia coli.
ر. Gunsalus (لوس أنجلوس): (1) Oxygen control of gene expression in E.coli. (2) Nitrate-dependent signal transduction and gene regulation.
ر. Kolter (Harvard): (1) Bacterial adaptation in stationary phase. (2) Population dynamics during stationary phase.
ص. Stragier (باريس): Cell-specific gene expression during sporulation in ب. subtilis.
ر. Moxon (Oxford): Utility of whole genome sequences of pathogenic bacteria.
D. Holden (لندن): Genetics of bacterial pathogenicity.
ج. Miller (لوس أنجلوس): Regualtion of bacterial pathogenicity and genetic analysis of virulence factor function.
G. Cornelis (Louvain): ال Yersinia Yop virulon.
T. Silhavy (Princeton): Genetic analysis of the general protein secretion pathway.
ص. Cossart (باريس): Listeria monocytogenes: tools and tricks of a bacterial pathogen to invade cells and tissues.
T. Meyer (دبليو?rzburg): Molecular pathogenesis of Neisseria.
ص. Sansonetti (باريس): Pathogenesis of Shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation.
Participants:
ص. Adams (Southampton), ك. Adelmann (Gif-sur-Yvette), R.M.J. Aamodt (Oslo), م. Ajonye (Bath), م. Ansaldi (Marseille), ر. Asano (Vancouver), T. Autio (هلسنكي), F. Backhed (Stockholm), أ. Balandina (باريس), ص. Benkel (Giessen), B.M.Bjorkholm (Stockholm), ج. Bjorkman (Stockholm), K.K.H. Blom (G?teborg), V.B. Borodulin (Saratov), T. Brauer-Steppkes (Bochum), K.W. Bruhn (لوس أنجلوس), ج. Carnoy (Lille), I. Chabchoub (Sfax)), V. Chubanov (Minsk), D. Clarke (Orsay), V. Doroshenko (Moscow), W.A. El-Adhami (Perth), س. Erksson (Stockholm), J.C. Espinosa (Madrid), M.A. Farris (Southampton), T.T. Frederiksen (Aarhus), V. Garcia Palacio (طوكيو), A.M. Geiger (م?nchen), G. Godaly (Lund), ب. Gonzalez-Zorn (Madrid), س. Grill (Wien), I. Gryllos (Sheffield), I. Gustafsson (Uppsala), Long Hang (Lund), R.D. Hayward (كامبريدج), Y. Hechard (Poitiers), ج. Hein (م?nchen), A.B.E. Helander (G?teborg), A.M. Hernendez-Arriaga (Madrid), أ. Hobta (Kiev), V. Hope (Nottingham), ج. Isak J?rgensen (Odense), E.K.V. Johnsson (Lund), أ. Jordanova (Sofia), ج. Josenhans (Bochum), س. Joyce (باريس), D. Kamashev (باريس), أ. Kasaks (Riga), ن. Kinsella (Southampton), ج. ك?nig (دبليو?rzburg), ك. Kostelidou (Birmingham), س. Kothandharaman (Madras), ر. Krishnaraj (Palkalaiperur), ك. Krogh Andersen (Dublin), G.I. Kutuzova (Moscow), A.K. Lee (Stanford), P.Lestrate (Namur), D. Llull Penalba (Madrid), E. Lopez-Solanilla (Madrid), E. Mamroud-Kidron (Ness-Ziona), R.A. Mateuca (Bucharest), G. de Medeiros Silva (Oeiras), M.L. Merroun (Granada), P.M. Miranda (Estoril), س. م?ller (Braunschweig), E. Mutoh (طوكيو), Z. Nawaz (Karachi), V. Nikitina (Saratov), T.I.V. Nogueira (باريس), س. Novella del Campo (Madrid), أ. Olsen (Aarhus), J.A. Oscarsson (Umea), J.M. Palacios Moreno (Aarhus), D. Panne (Basel), M.C. Para Caballero (Madrid), R.M. Parreira (Lisboa), م. Persuh (نيويورك), ص. Peyron (Toulouse), ج. Piedade (Lisboa), ج. Pizarro-Cerda (Marseille), م. Pope (Vancouver), ك. Ragkousi (Nottingham), أ. Rak (Pushino), P.H. Remane (Braunschweig), ح. Sahly (Kiel), Y.O. Sanogo (Brno), م. Scocchi (Udine), E. Sergeeva (Saratov), ح. Sinha (كامبريدج), G. Spohn (Siena), P.T. Tassios (Athens), T. Tenson (Tartu), A.-C. Thoreson (G?teborg), E. Thorolfsdottir (Reykjavik), أ. Tochetti (Milano), أ. Tover (Tartu), ن. Tvetkov (Sofia), م. Uno (طوكيو), Y. Vega Rocha (Madrid), ر. Vipond (Salisbury), م. Viveiros Tettencourt (Liboa), م. Vulic (باريس), م. Westermark (Umea), ج. Dammel (Haywward), أ. Miasnikov (Kantvik), D.T. Nieuwlandt (Boulder).
SPETSES 1999
Augst 29 – September 9
STRUCTURE AND FUNCTION OF MACROMOLECULAR COMPLEXES
Organizers: Efstathis Gonos (اليونان), Matthias Hentze (ألمانيا), John Hershey (الولايات المتحدة الأمريكية), Lev Kisselev (روسيا), John McCarthy (U.K.)
Lecturers and Lectures:
August ب?ck (Institut f?r Genetik und Mikrobiologie, Universit?t M?nchen)
(أنا) Recoding mechanism of the Genetic Code; (ثانيا) Insertion of seleno-cysteines into proteins
Irene Bozzoni (Dipt. Genetica e Biologia Molecolare, La Sapientia, Rome)
(أنا) & (ثانيا) Sno RNAs: function and biosynthesis
Agamemnon J. Carpousis (Lab. Microbiologie et G?n?tique Mol?culaire, Toulouse)
(أنا) RNA degradation complexes in bacteria; (ثانيا) Bacterial poly(أ) polymerase
Bernhard Dobberstein (Zentrum f?r Molekulare Biologie, Heidelberg)
(أنا) Protein targeting to the membrane of the endoplasmic reticulum; (ثانيا) Protein translocation across the membrane of the endoplasmic reticulum
Ellie Ehrenfeld (المعاهد الوطنية للصحة, Bethesda)
(أنا) Virus replication and gene expression; (ثانيا) Polio virus replication and effects on the host cell
Pamela Green (Plant Research Laboratory, East Lansing)
(أنا) & (ثانيا) mRNA decay in eukaryotes
Marianne Grunberg-Manago (Institut Pieree et Marie Curie, باريس)
(أنا) A History of the Spetses Summer School; (ثانيا) mRNA stability and its role in control of gene expression in bacteria and phages
Ulrich Hartl (MPI f?r Biochemie, Martinsried)
(أنا) & (ثانيا) Function of molecular chaperones and heat-shock proteins in folding proteins
Matthias W. Hentze (EMBL, Heidelberg)
(أنا) Regulation of translation by RNA-binding proteins; (ثانيا) Recognition of nonsense codons by translation complexes
John W.B. Hershey (Dept. Biological Chemistry, UC Davis)
(أنا) The pathway and mechanism of initiation of protein synthesis; (ثانيا) The structure-function of eIF3
Walter Keller (Biozentrum, Basel)
(أنا) 3′-end processing of mammalian mRNA precursors; (ثانيا) 3′-end processing of yeast mRNA precursors
John McCarthy (UMIST, Manchester)
(أنا) & (ثانيا) Posttranscriptional control: methods, concepts, numbers
Kiyoshi Nagai (MRC. كامبريدج)
(أنا) Structural basis of RNA-protein interactions; (ثانيا) The spliceosome
Yoshikazu Nakamura (Institute of Medical Science, طوكيو)
(أنا) & (ثانيا) Regulation of translation termination and recoding
Walter Neupert (Adolf-Butenandt-Institut, م?nchen)
(أنا) & (ثانيا) Topogenesis of proteins of mitochondria
Joan A. Steitz (Yale University, New Haven)
(أنا) & (ثانيا) Pre-mRNA splicing
Thomas A. Steitz (Yale University, New Haven)
(أنا) Ribosome structure and function; (ثانيا) Structure and function of protein synthesis elongation factors
Geoffrey Turner (Dept. Molecular Biology and Biotechnology, Sheffield)
(أنا) Peptidyl synthetases: Distribution and evolution; (ثانيا) Peptidyl synthetases: Functional analysis
Dieter H. Wolf (Institut f?r Biochemie, Stuttgart)
(أنا) Structure and assembly of the 26S proteasome, the central proteolytic particle of all eukaryotic cells; (ثانيا) Quality control in the endoplasmic reticulum: retrograde protein transport through the Sec61 translocon and its end in the proteasome
Participants:
Varaklioti Agoritsa (Athens); Eleftheria Argyrou (Athens); Patrick Bakkes (Amsterdam); Richard Bayliss (كامبريدج, المملكة المتحدة); Natalya Belkina (Moscow); Artemy Beniaminov ((Moscow); Michela Bertero (Pavia); Snaedis Bj?rnsdottir (Reykyavik); Jennifer Blanchette (Ann Arbor); Sergei Boudko (Moscow); Pietro Boyl (Rome); Tatyana Budkevich (Kiev); Nuria Campillo (كامبريدج, المملكة المتحدة); Anne Carr-Schmid (Piscataway); Gina Clayton (كامبريدج, المملكة المتحدة); Siska Cochran (Manchester); Maria Dahle (Oslo); Vita Dauksaite (Uppsala); Aneta Dobruk (وارسو); Svetlana Dokudovskaya (Moscow); Morten Elholm (Bergen); Alessandro Fatica (Rome); Fedor Forafonov (Saint Petersburg); Silvia Galardi (Rome); Daniela Galli (Rome); Sven Geibel (Frankfurt/M); Zeynep Gerek (Istanbul); Nicholas Glykos (Heraklion); Igor Goncharov (Rehovot); Esther Guarinos (Madrid); Jacoba Stagter J?ger (Uppsala); Alexander Jgoun (Moscow); Pall Jonsson (Kopavogur); Zemfira Karamysheva (طوكيو); Adrej Kariakin (Moscow); James Kastenmayer (East Lansing); Natalya Kholod (Moscow); Mehtap Kilic (Antalya); Sokolov Kirill (Moscow); Nadejda Koloteva (Tel Aviv); Elizaveta Kovrigina (Pushino); Edgar Kramer (فيينا); Inna Krieger Hyogo); Mette Kristensen (Copenhagen); Svetlana Kuptsova (Moscow); Yusuf Kurtumus (?zmir); Sofia Larsson (Huddinge); Susanne Leonhartsberger (Munich); Michael Lisurek (Saarbr?cken); Marco Lutz (Groningen); ?lo Maiv?li (Tartu); Cristina Marino-Busljc (كامبريدج,المملكة المتحدة); Kirill Martemyanov (Pushino); Racula Mateuca (Bucharest); Mads Wichmann Matthiesen (Copenhagen); Greg Mayeur (Davis); Jeanne Menez (باريس); Oliver Mohseni (Stockholm); Thorleif M?ller (Odense); Jakob M?ller-Jensen (Odense); Patrick Morris (Little Rock); Oleg Murashko (Minsk); Boris Negrutskii (Kiev); Teresa Noguiera (باريس); Joy Okpuzor (Lagos); Christina Olsson (Lund); David Page (Edinburgh); Chariklia Petropoulou (Athens); Lionel Pintard (Montpellier); Lukia Psaridi (Athens); Lambrini Psiouri (Patras); Marina Ptushkina (Manchester); Agnes Rinaldo-Matthis (Stockholm); Allison Robb (Edinburgh); Yury Rubtsov (Moscow); Ekatarina Rusakova (Moscow); Cyril Saguez (Gif-sur-Yvette); Chiara Scerch (Monterotondo); Thomas Schell (Heidelberg); Jan Schirawski (باريس); Thomas Sebastian (Kerala); Elena Sergeeva (Saratov); Petr Sergiev (Moscow); Vyacheslav Shalak (Kiev); Olga Shpachenko (Moscow); Daria Sizova (Moscow); Vladlen Skvortsov (Moscow); Evgeniya Smirnova (Moscow); Alicia Solorzano (Salamanca); Irina Sominskaya (Riga); Martin Stancek (Stockholm); Margarita Tenopoulou (Ioannina); Martin Thanbichler (Munich); Neslihan Toyran (Ankara); Jennifer Tusz (Szeged); Nikolay Tzvetkov (Nagoya); Louise Unwin (Leeds); Patricia Vazquez (Madrid); Carmen Velasco Ramirez (Manchester); Christina Vilela (Manchester); Stefan Walke (كامبريدج,المملكة المتحدة) Daniel Williams (Dundee); Matt Winkler (Austin); Jonathan Wood (Leeds); Wendy Wood (Brighton); Kuniyasu Yoshimura (طوكيو); Natalia Zakataeva (Moscow); Vladimir Zeenko (Basel); Chunying Zhu (Copenhagen).
SPETSES 2000
September 5 to September 13
MOLECULAR MECHANISMS OF DEVELOPMENT AND DISEASE
Basic molecular mechanisms of cell function and their implications in disease
Developmental aspects, developmental models
Disease mechanisms
Organizers: Peter Herrlich, Chairman (ألمانيا), Herbert Jaeckle (ألمانيا), Efstathis Gonos (اليونان), Horst Feldmann (ألمانيا)
Lecturers and Lectures:
Patrick Baeuerle (Martinsried/Munich, ألمانيا)
(أنا) Ordering principles in Signaling/Signal Transduction (ثانيا) Academia and industry: what to learn from each other
Piet Borst (Amsterdam, NL)
(أنا) Antigenic variation in trypanosomes; (ثانيا) Drug resistance in cancer cells.
Steven Burley
Wolfgang Driever (Freiburg, ألمانيا)
(أنا) Mechanisms in the development of zebrafish; (ثانيا) Zebrafish: tools for investigating cellular differentiation.
Walter Gehring (Basel, سويسرا)
(أنا) Homeobox genes and the specification of the body plan (ثانيا) Master control genes in morphogenesis and evolution of the eyes
Dirk G?rlich
Peter Gruss (G?ttingen, ألمانيا)
(أنا)Molecular mechanisms underlying brain development (ثانيا) Cortex development/Organogenesis
Peter Herrlich (Karlsruhe, ألمانيا)
(أنا) Mouse mutants for the analysis of transcriptional regulation (ثانيا) Neurofibromatosis Type 2
Jan Hoejimakers
Wolfram ح?rz (Munich, ألمانيا)
(أنا) Nucleosomes and their interactions with regulatory factors; (ثانيا) Role of the chromatin structure in the expression of the phosphatase gene family in yeast.
Robert Horvitz (كامبريدج, الولايات المتحدة الأمريكية)
Programmed cell death in C. elegans
Herbert ج?ckle (G?ttingen, ألمانيا)
(أنا) Transcription factors in Drosophila تطوير; (ثانيا) homeotic and gap genes in Drosophila.
Rudolf Jaenisch (كامبريدج, Massachusetts, USA.)
(أنا) DNA repair; (ثانيا) Methylation and expression patterns of imprinted and nonimprinted genes.
Fotis C. Kafatos (Heidelberg, ألمانيا)
(i and ii) Innate Immunity and Malaria.
Reinhard L?hrmann
Iain Mattaij (Heidelberg, ألمانيا)
(أنا) Nucleocytoplasmic transport; (ثانيا) Ribonucleoprotein assembly
Ueli Schibler (جنيف, CH)
(أنا) Chronobiology: from cynobacteria to man (ثانيا) Circadian gene expression in animals and cells
Axel Ullrich (Martinsried/Munich, ألمانيا)
Growth factor receptors
Inder M. Verma (San Diego CA, الولايات المتحدة الأمريكية)
(i and ii) العلاج الجيني.
Robert Weinberg (Cambridge MA, الولايات المتحدة الأمريكية)
(أنا) Tumor suppressor genes; (ثانيا) Apoptosis.
تشارلز Weissmann (Zurich, سويسرا)
(أنا) Prion diseases in animals and humans (ثانيا) Molecular biology of prion diseases
Alan P. Wolffe (Bethesda MD, الولايات المتحدة الأمريكية)
(أنا) Regulatory roles for chromatin: structure and transcriptional activation (ثانيا) Regulatory roles for chromatin: heterochromatin and transcriptional repression
SPETSES 2001
September 4 to September 14
PROTEIN BIOLOGY: FROM SYNTHESIS TO FUNCTION AND DISEASE
Organizers: Brian F.C. Clark (chairman) (الدنمارك), Alan R. Fersht (المملكة المتحدة), Efstathis Gonos (اليونان), Daniela Rhodes (المملكة المتحدة)
المواضيع:
(1) Protein Synthesis and Macromolecular Mimicry
(2) Folding and Quality Control
(3) Protein Folding
(4) Targetting and Trafficking
(5) Maturation, Recognition and Degradation
(6) Proteomics and Bioinformatics
(7) Protein Design
(8) Misfolding and Disease
Lecturers:
Wolfgang Baumeister (ألمانيا), Julio Celis (الدنمارك), Aaron Ciechanover (Israel), Brian Clark (الدنمارك), Elena Conti (ألمانيا), Chris Dobson (المملكة المتحدة), Alan Fersht (المملكة المتحدة), Susan Grasser (سويسرا), Stathis Gonos (اليونان), Gunnar von Heijne (السويد), Ari Helenius (سويسرا), Matthias Hentze (ألمانيا), Walter Neupert (ألمانيا), Andreas Pl?ckthun (سويسرا), Daniela Rhodes (المملكة المتحدة), Chris Sander (الولايات المتحدة الأمريكية), Luis Serrano (ألمانيا), Mathias Uhlen (السويد), تشارلز Weissmann (المملكة المتحدة).
Participants:
Charlotta Agaton (KTH, Royal Institute of Technology, س- 100 44 Stockholm, السويد); Burcu Anar (Erasmus University,3000 DR, Rotterdam); Tiziana Anelli (Istituto Scientifico San Raffaela, 20132 Milano);Vassiliki Avramopoulou (Hellenic Pasteur Institute, 115 21 Athens), Alexandre Avsiouk (Moscow State University, 117333 Moscow ); Natalia Beloglazova (Academy of Sciences 8, Lavrentien Av., 630090, Novosibirsk 90); Petra Berg (CMB, S-171-77 Stockholm ); Angela Bisso (DIMES – Sezione Biochimica, 16132 Genova); Catherine Bruel (Institute of Clinical Biochemistry and Pathobiochemistry, 98078 دبليو?rzburg);Anne-Laure Bulteau (Universit? باريس 7 – Denis Diderot, 75251 Paris Cedex 05); Barbara Campanini (Universit? degli Studi di Parma, 43100 Parma ); Susan L. Campbell (Institute for Animal Health, Edinburgh, EH9 3JF); Andrew Carter (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Pedro Castanheira (Universidade de Coimbre, 3001 401 Coimbra); Marta Rodriguez Castro (Instituto de Salud Carlos III,28220 Madrid); Urska Cegovnik (Institute of Oncology, 1000 Ljubljana); Niki Chondrogianni (National Hellenic Research Foundation, 166 35 Athens); Daniel Christ (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Robert Court (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Adrian Creanga (Institute of Biochemistry, Bucharest 77700); Robert Dobrovolny (Institute of Inherited Metabolic Diseases, 128 08 Praha 2); Melloney Dr?ge (University of Groningen, 9713 AV Groningen); Marta Fikus (Polish Academy of Sciences, 02-106 Warszawa); Parthena Foltopoulou (Aristotle University of Thessaloniki, Thessalonki 540 06); Linda Frederiksson (Ludwig Institute for Cancer Research, 171 77 Stockholm); Steffen Frey (Zentrum f?r Moleculare Biologie Heidelberg, 69120 Heidelberg); Rikke From Fr?hlich (University of Aarhus, 8000 Aarhus C); Behzad Gharehnia (University of Bergen, 5021 Bergen); Stefania Gobessi (Universit? degli Studi di Udine, 33100 Udine); Alina Grabiec (Jagiellonian University, 31-120 Krakow); Ekaterina Gresko (Inselspital, 3010 Bern); Carol Harty (Cambridge Institute for Medical Research, Cambridge CB2 2XY); Florian Hollfelder (Department of Biochemistry, Cambridge CB2 1GA);Tijana Ignjatovic (MRC Laboratory of Molecular Biology, Cambridge CB2 1TQ); Hideo Iwai (Biochemisches Institut , Universitaet Zurich, CH-8057 Zurich); Ghil Jona (Weizmann Institute of Science, Rehovot); Kim Bak Jensen (University of Aarhus, 8000 Aarhus C); Alexandra Kaser (Austrian Academy of Sciences, 5020 Salzburg); Katin Kepp (University of Tartu, Tartu 51010); Ilkka Lappalainen (University of Helsinki);Michael Lappe (Wolfson College, Cambridge CB3 9BB); Natalia A. Lebedeva (Institute of Bioorganic Chemistry, Novosibirsk 630090 ); Rune Linding (EMBL, D-69117 Heidelberg); Kresten Lindorff-Larsen (2300 ك?benhavn S); Efthimia Lioliou (Aristotle University of Thessaloniki, 54006 سالونيك); Adrianna Loniewska (Polish Academy of Sciences, 02-106 Warszawa); Manuela L?pez de la Paz (European Molecular Biology Laboratory, D-69117 Heidelberg ); Ewan Main (Dept. of Molecular Biophysics and Biochemistry, New Haven, Connecticut 06520-8114); Vlatka Makanec (PLIVA Reseach Institute, 10 000 Zagreb); Francisco Mansilla Castano (University of Aarhus, 8000 Aarhus C); Tomoaki Matsuura (Biochemisches Institut Universitaet Zurich , CH-8057 Zurich); Ugo Mayor (Centre for Protein Engineering, CB2 2DQ Cambridge); Tanja Meriluoto (National Public Health Institute, 00251 هلسنكي); Jesper Mogensen (Department of Biotechnology Aalborg University, 9100 Aalborg); Olga V. Molchan (Belorussian Academy of Sciences, Minsk 220072); Zoryana Oliynyk (Centre for Protein Engineering, MRC, Cambridge CB2 2QH); Krzysztof Olszak (Institute of Biochemistry and Biophysics PAS, 02-106 وارسو); Jennifer L. Ong (MRC Laboratory of Molecular Biology, Cambridge CB2 2QH); Juha Paloneva (National Public Health Institute, هلسنكي); Alla Pogribna (Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev 252143); Rosa Resende (Universidade de Coimbra, 3004 517 Coimbra); Ekaterina Rusakova (Engelhardt Institute of Molecular Biology, 117984 Moscow); Carsten Schwalb (University of Edinburgh, Edinburgh EH9 3JR); Burckhard Seelig (Harvard Medical School, Boston MA 02114); Markus Seeliger (Cambridge University Chemical Laboratory, Cambridge CB2 1EW); Toomas Silla (University of Tartu, Tartu 51010);Frederico Silva (Instituto de Biologia Molecular e Celular, 4150 180 Porto); Federica Sinibaldi (Universita “Tor Vergata” di Roma, 00133 Rome); Elena Sokolova (Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997); Therese Solstad (PKI, IBMB, 5020 Bergen); Teresa Soop (MoG, CMB, Karolinska Institute, 171 77 Stockholm); Tam?s Sperka (University of Debrecen, 4012 Debrecen); Kaare Teilum (Institute of Molecular Biology, University of Copenhagen, 1353 Copenhagen K); Hana Tomincov? (Academy of Sciences of the Czech Republic, 166 37 Praha 6); Ioannis P. Trougakos (National Hellenic Research Foundation (N.H.R.F.), 11635, Athens Greece); Katharina Reksten Tufteland (University of Bergen, HIB, 5020 Bergen); Ann Vanhooren (Catholic University Leuven ,8500 Kortrijk); Lidia Vasilieva (University of Helsinki, 00014 هلسنكي); Ioulia Vassilieva (Institute of Protein Research, 142290 Pushchino, روسيا); Ana V. Vilar (Universitat de Barcelona, 08028 برشلونة);Gordon Whamond (University College London, London WC1E 6BT); Kate Wickson (UMIST, Manchester M60 1QD); Anna Zajakina (University of Latvia, Riga LV 1067); Bernd Buchberger Roche Diagnostics GmbH, Werk Penzberg, Nonnenwald 2, 82372 Penzberg, ألمانيا); Christine Dartsch (AstraZeneca Biotech Lab, ب:841, 151 85 س?dert?lje, السويد)
SPETSES 2002
September 3 to September 13
MOLECULAR BIOLOGY OF BACTERIAL INFECTIONS
Organizers: Pascale Cossart (Institut Pasteur, فرنسا)(Chairperson), Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية); Efstathios Gonos (Hellenic Research Foundation, اليونان).
المواضيع:
Invasive bacteria
أنظمة
Protein export and secretion in bacteria
Intravacuolar pathogens
Genomics/ Post Genomics
Bacterial toxins
Virulence genes organisation
Evading the host defense systems
Evading hostile environments
Antiphagocytosis
Lecturers and Lectures:
Patrice Boquet (Nice, فرنسا)
Bacterial toxins : basic concepts (أنا) ; Bacterial toxins : what do these proteins tell us about host cell molecular mechanisms (ثانيا)
Pascale Cossart (باريس, فرنسا)
Genetics and Cell biology of Listeria infections: from in vitro to in vivo data (أنا); Listeria monocytogenes : new insights in virulence (ثانيا)
Guy Cornelis (Bruxelles, بلجيكا)
The Yersinia injectisome (أنا); The cell biology of the Yop effectors (ثانيا)
Antonello Covacci (Siena, إيطاليا)
Virulence factors in Helicobacter pylori, Pathogenicity islands and Cell biology (أنا); Bioinformatics and Microbes (ثانيا)
Julian Davies (Vancouver, كندا)
What is an antibiotic (أنا); The complexity of antibiotic resistance (ثانيا)
Efstathios S. Gonos (Athens, اليونان)
The molecular genetics of human ageing and longevity
David Holden (لندن , المملكة المتحدة)
Methods to study Salmonella virulence in vivo (أنا); Intracellular Biology of Salmonella (ثانيا)
Roberto Kolter (بوسطن, الولايات المتحدة الأمريكية)
Thinking about bacteria as multicellular organisms : implications to pathogenesis and survival (أنا); Bacterial biofilms in chronic infections (ثانيا)
Gunnar Lindahl (Lund, السويد)
Bacterial immuno-globulin binding proteins and their role in virulence (أنا); Antigenic variation and its molecular basis : Group A Streptococcus as a model system (ثانيا)
Jeff Miller (لوس أنجلوس, الولايات المتحدة الأمريكية)
A mechanistic, evolutionary and ecological perspective on bacterial gene regulation (أنا); Parasite adaptations to dynamic hosts: the infectious cycles of Bordetella and their phages
Edgardo Moreno (Heredia, Costa Rica)
Brucella pathogenesis
Tony Pugsley (باريس, فرنسا)
تاريخ, background and relationships to other protein translocation systems (أنا); One, two and three membranes (ثانيا)
Philippe Sansonetti (باريس, فرنسا)
What is a pathogen ? (أنا) ; Molecular and cellular basis of Shigella infections (ثانيا)
Pam Small (Knoxville, الولايات المتحدة الأمريكية)
What can we learn from genomics about virulence in Mycobacteria species (أنا); Lipid-mediated virulence in Mycobacterial pathogens; macrolides polyketides and beyond (ثانيا)
Arturo Zychlinsky (نيويورك, الولايات المتحدة الأمريكية)
Is there a physiological role for apoptosis in bacterial pathogenesis ? (أنا); Innate immunity in bacterial infections (ثانيا)
Participants 2002
David Ackerley (Stanford, الولايات المتحدة الأمريكية), Sarojini Adusumilli (Knoxville, الولايات المتحدة الأمريكية), Irini Lazou Ahr?n (Malm?, السويد), Ana Maria Alonso Santos (Cantoblanco-Madrid, إسبانيا); Alexander Avsyuk (Moscow, روسيا); Stina Berglund (Umea, السويد); Juan Pablo Bifani (Lille, فرنسا); Eva Bjur (Stockholm, السويد); Igor Brodsky (Stanford, الولايات المتحدة الأمريكية); Didier Cabanes (باريس, فرنسا); Barbara Capecchi (Siena, إيطاليا); Anna Carle (Munich, ألمانيا); Fredric Carlsson (Lund, السويد); Ronan Carroll (Dublin, Ireland); Claire Checroun (Toulouse, فرنسا ); Rebecca Jane Critchley (لندن, المملكة المتحدة); Daniele Dessi (Sassari, إيطاليا); Gustavo Dominguez Bernal (Cantoblanco-Madrid, إسبانيا); Isabel Eloi Marcelino (Oeiras, البرتغال); Lisa Friedman (بوسطن, الولايات المتحدة الأمريكية); Diana Goldenberg (Ramat Aviv, Israel ); Ernesto Gonzalez de Valdivia (Stockholm, السويد); Marie Gottar (Strasbourg, فرنسا); Edith Gouin (باريس, فرنسا); Julien Goure (Grenoble, فرنسا); Helga Gressmann (Berlin, ألمانيا); Cyril Hamiaux (Groningen, The Netherlands); Katherine Hisert (نيويورك, الولايات المتحدة الأمريكية); Christopher Hoppner (Munich, ألمانيا); Ofir Ilan (Jerusalem, Israel); Vanesa Ivetic (Zagreb, Crotia); Harry J?rvel?inen (Berlin, ألمانيا); Mariluise Kirchner (Berlin, ألمانيا); Kaoru Komoriya (Oxford, المملكة المتحدة ); Natalia A. Kozak (لوس أنجلوس, الولايات المتحدة الأمريكية); Xin-He Lai (Umea, السويد); Maria Carmela Latella (Roma, إيطاليا); Mirjana Macvanin (Uppsala, السويد); Lena Mogemark (Umea, السويد); Daphna Mokady (Ramat Aviv, Israel); Ernesto J. Munoz-Elias (نيويورك, الولايات المتحدة الأمريكية); Eike Niehus (دبليو?rzburg, ألمانيا); Maria Jos? Oliveira (Ghent, بلجيكا); Francesca Pacello (Roma, إيطاليا); Effrosyni Papanikou (Crete, اليونان); Suzana Pinto Salcedo (لندن, المملكة المتحدة); Helmy Rachman (Berlin, ألمانيا); ب?rbel Raupach (Berlin, ألمانيا); Jean-Marc Reyrat (باريس, فرنسا); Federica Ribacchi (Roma, إيطاليا); Lars Roese (Berlin, ألمانيا); Piklu Roy Chowdhury (Christchurch, نيوزيلندا); Daniela Santapaola (Roma, إيطاليا ); Anja Seubert (Basel, سويسرا); Marcela Simsova (Prague, Czech Republic); Carlos Yesid Soto Ospina (Zaragoza, إسبانيا); Sandra Sousa (Pari, فرنسا); Kathryn E. Stockbauer (لوس أنجلوس, الولايات المتحدة الأمريكية); Charlotta Sundin (Umea, السويد); Neil Surana (Saint-Louis, الولايات المتحدة الأمريكية); Damini Tapadar (Muenster, ألمانيا); Alejandro Toledo Arana (Pamplona, Navarra, إسبانيا); Elisabeth Torstensson (Stockholm, السويد); Sara Travaglione (Roma, إيطاليا); Andr? Van Eerde (Groningen, The Netherlands); Tanay Veremeiko (Novosibirsk, روسيا); Nicolas Vodovar (Gif sur Yvette, فرنسا); Su-Yan Wang (Umea, السويد); David S. Weiss (Berlin, ألمانيا); Hanne C. Winther-Larsen (Oslo, Norway); Chen Yona (Jerusalem, Israel); Ming Yuan (Umea, السويد); Maria Mercedes Zambrano (Bogota, Colombia).
SPETSES 2003
August 29 to September 8
MOLECULAR MECHANISMS IN HOMEOSTASIS AND DISEASE
Organizers: Peter Herrlich, Jena; Herbert J?ckle, G?ttingen; Horst Feldmann, م?nchen; Martin Blum, Stuttgart-Hohenheim; Peter Angel, Heidelberg, Statis Gonos, Athens.
المواضيع:
(1) Sources of dysfunction of cellular and organismic processes
(2) Embryonic development and tissue remodelling
(3) Molecular mechanisms of disease (myeloid and bone diseases; reperfusion syndrome; parasitic diseases; human retrovirus-induced diseases; الأمراض التنكسية العصبية; prion diseases; cancer including immunoevasion, metastatic mechanisms, early dissemination, drug resistance).
Lecturers and Lectures:
| Aguzzi, Adriano (Zurich) | Pathogenesis of prion diseases: mouse models |
| Angel, Peter (Heidelberg) | Wound healing and skin remodelling |
| Blum, Martin (Hohenheim) | Pattern formation in early embryonic development (أنا); Establishment of left-right asymmetry in vertebrates (ثانيا) |
| Borst, Piet (Amsterdam) | Mechanisms of antigenic variation in parasites (أنا); Drug transporters in health and disease (ثانيا) |
| Christofori, Gerhard (Basel) | Multistage tumorigenesis 1. Early events: proliferation and survival; 2. Late events: tumor angiogenesis and progression to malignancy |
| Clevers, Hans (Utrecht) | Patterning of the colon epithelium (أنا); Colon Differentiation and Colon Cancer (ثانيا) |
| Feldmann, Horst (م?nchen) | Programmed proteolysis |
| Gasser, Susan (جنيف) | Chromatin dynamics in the interphase nucleus (أنا); DNA replication checkpoints and what happens when forks stall (ثانيا) |
| Gonos, Efstathios (Athens) | Mechanisms of ageing |
| Haass, Christian (م?nchen) | الأمراض التنكسية العصبية (أنا); الزهايمر (ثانيا) |
| Herrlich, Peter (Jena) | A human disease defective in a novel step of signal transduction: a regulatory role for the link between actin cytoskeleton and plasma membrane |
| ح?rz, Wolfram (م?nchen) | Chromatin structure (أنا); Chromatin in transcriptional regulation (ثانيا) |
| Karin, Michael (La Jolla) | The IكB Kinase (IKK) – A Signaling Machine and its Role in Innate and Adaptive Immunity (أنا); The role of IKK and NF-كB in skin development and pathology vertebrates (ثانيا) |
| Klobeck, Hans-Gustav (م?nchen) | Activation of immunoglobulin gene loci during B cell development |
| Kr?usslich, Hans-Georg (Heidelberg) | Retrovirus-induced disease (أنا); Virus assembly and maturation (ثانيا) |
| L?hrmann, Reinhard (G?ttingen) | The RNA splicing machinery; alternative and aberrant splicing (i and ii) |
| Niehrs, Christof (Heidelberg) | Organ development and organizer centers in vertebrates (i and ii) |
| Schibler, Ueli (جنيف) | Molecular biology and physiology of circadian rhythms |
| Simons, Kai (Dresden) | Intracellular protein transport (أنا); Lipid rafts and cell polarity (ثانيا) |
| Ulrich, Axel (Martinsried) | Crosstalk in the cellular communication network: intervention in cancer progression (أنا); Signaling pathways as targets for therapeutic intervention in cancer progression (ثانيا) |
| Verma, Inder (La Jolla) | BRCA1/2 (أنا); العلاج الجيني (ثانيا) |
| Wagner, Erwin F. (فيينا) | Mouse models for human disease (أنا); Myeloid and Bone diseases (ثانيا) |
| Weissmann, تشارلز (لندن) | Prion diseases in men |
| Werb, Zena (سان فرانسيسكو) | Remodelling of the cellular microenvironment (أنا); Animal models with metalloprotease deficiencies (ثانيا) |
Participants:
Abakushin, Dmitri, Obninsk; Alimohammadi, Mohammad, Uppsala; Anders, Lars, Martinsried; Antoszczyk, Slawomir, Lodz; Appel, Thomas, IMB Jena; Araujo, Ines, Coimbra; Baccarini, Sara, Roma; Bespalov, Igor, Moscow; Bidzhieva, Bella, Mytishy; Brichkina, Anna, شارع. Petersburg; Cardoso, Carla, Coimbra; Deas, Emma, لندن; Deissler, Kirsten, Hohenheim; Dostert, Anja, فرانكفورت; Ducasse, Miryam, فرانكفورت; Fazi, Barbara, Rome; Federova, Olga, Moscow; Fern?ndez Lloris, Raquel, برشلونة; Ferraro, Elisabetta, Rome; Fj?llman, Ann, ETH Z?rich; Fleishman, Darya, Moscow; Gela, Anna, Karlsruhe; Giacinta, Cristina, Roma; Gil, Joana, Coimbra; Gu, Ven Li, Bonn; Gulati, Pawan, Karlsruhe; Heikenw?lder, Mathias, Z?rich; Heilbock, Christine, Karlsruhe; Hertl, Christina, م?nchen; Horvath, Bela, Budapest; Hoya-Arias, Ruben, Gent; Illarionova, Anna, Moscow; Isamberth, Nicolas,; Ivanova, Nevyana, Sofia; Jensen, Jan. م. , UCHSC; Kaganski, Alexander, شارع. Petersburg; Karcher, Christina, Hohenheim; Khodosevich, Konstantin, Moscow; Kie?lich, Almut, Jena; Kiialainen, Anna Karoliina, هلسنكي; Kireev, Roman, Saratov; Klein , Isabella, Budapest; Klochkov, Denis, Moscow; Kohli, Bernhard, Zurich; Kolesnikova, Olga, Moscow; Koriakina, Janna, Dniepropetrovsk; Koricanac, Lela, Belgrade; Krasnobryzha, Ievgenia, Kiev; Kren, Angelika, Basel; Krick, Stefanie, Giessen; Kryndushkin, Dmitrij, Moscow; Lalle, Marco, Rome; Lombardo, Marco, Rome; Matthiesen, Sonja, Bonn; McKintosh, Edward, لندن; Michelson, Piret, Tallin; Misyurina, Olga, Gamaley; Mladenovic, Aleksandra, Belgrade; م?ll, Kaidi, Tartu; م?ller, Regina; Ndlovu, Matladi, Gent; Njunkova, Olga, Tallinn; Okutuku, Burku, Izmir; Oliveira, Carla, Porto; Oliveira Martins, Maria T., Coimbra; Parlato, Rosanna, Heidelberg; Perovic, Milka, Belgrade; Petrenjov, Daniil, Minsk; Piltti, Katja, هلسنكي; Pondiki, Stavroula, Athens; ص?ntynen, Nora Maria, هلسنكي; Pripuzova, Natalia, Moscow; Pustovidko, Antonina, Moscow; Rafikova, Elya, Moscow; Raicevic, Nevena, Belgrade; Reichwald, Kathrin, Jena; Reinke, Hans, م?nchen; Rottenberg, Sven, Bern; Rotz, von, Ruth, Zurich; Ruschel, Anja, Martinsried; Sander, Veronika, Salzburg; Schaper, Manuela, Bern; Semenova, Elena, Novosibirsk; Shkundina, Irina, Moscow; Shtam, Tatjana, شارع. Petersburg;Sperka, Tobias, Karlsruhe; Stamatakis, Antonios, Athens; Stamenkovic, Kristina, Nis; Stoebe, Petra, Stuttgart; Tamkovich, Svetlana, Novosibirsk; Telegina, Ekatarina, Pushchino; Terekhova, Alena, Obninsk; Tomas, Antonia, Madrid; Tothova, Jana, Padova; Tschoep, Katrin, Leipzig; Tsruya, Rachel, Rehovot; Vallabhuparapu, Sivakumar, Karlsruhe; Vereschagina, Anna, Obninsk; Vicente, Almeida, Sandra, Coimbra; Xuan Li, Xuan, Birmingham; Yilmaz, Buket, Bilkent, Ankara; Y?lmeztepe, Arzu, Uluda.
SPETSES 2005
September 5 ل 15
PROTEIN MISFOLDING, PROTEIN MODIFICATION AND AGE-RELATED DISEASES
Organizers: Alan R. Fersht (المملكة المتحدة) (chairman), Brian F.C. Clark (الدنمارك), Efstathios Gonos (اليونان), Daniela Rhodes (المملكة المتحدة), Mathias Uhlen (السويد)
Lecturers and Lectures:
| Wolfgang Baumeister (MPI Martinsried, ألمانيا) | (أنا) Cryoelectron tomography: why and how it is done and some state-of-the-art applications; (ثانيا) Cryoelectron tomography: towards a macromolecular atlas of the cell |
| Vilhelm Bohr (NIH Baltimore, الولايات المتحدة الأمريكية) | (أنا) DNA damage and repair; (ثانيا) DNA repair deficiencies in human premature aging |
| Judith Campisi (Berkeley, الولايات المتحدة الأمريكية) | (أنا) Cellular and molecular basis of aging; (ثانيا) DNA damage and senescence |
| Aaron Ciechanover (Technicon, Haifa, Israel) | (أنا) Intracellular protein degradation: historical perspectives; (ثانيا) N-terminal ubiquitination: not such rare modification anymore? |
| Brian Clark (Aarhus, الدنمارك) | توليف, البروتينات, modification and aging |
| Jane Clarke (كامبريدج, المملكة المتحدة) | (أنا) Single-molecule studies of proteins; (ثانيا) Investigating the complex unfolding landscapes of an elastic protein |
| Valerie Daggett (Seattle WA, الولايات المتحدة الأمريكية) | (أنا) Fundamentals of Molecular dynamics simulations and their application to protein folding; (ثانيا) Investigation of amyloidogenic conformational changes with molecular dynamics simulations |
| Chris Dobson (Oxford, المملكة المتحدة) | (أنا) Protein misfolding and amyloid disease; (ثانيا) Opportunities for therapeutic intervention in amyloid disorders |
| Rosario Fernandez-Fernandez (MRC Cambridge, المملكة المتحدة) | (أنا) Cancer overview; (ثانيا) p53 tumour suppressor network |
| Alan Fersht (كامبريدج, المملكة المتحدة) | (أنا) Fundamentals of protein folding and misfolding; (ثانيا)Protein instability and cancer |
| Stathis Gonos (Athens, اليونان) | (أنا) Clusterin/apolipoprotein J is a novel biomarker of senescence that regulates cellular growth and suppresses apoptosis; (ثانيا) Proteasome function during human aging |
| Thomas Jenuwein (IMP Vienna, Austria) | (أنا) The epigenome in the context of the post-genomic era; (ثانيا) The profile of repeat-associated histone lysine methylation states in the mouse epigenome |
| Daniela Rhodes (MRC Cambridge, المملكة المتحدة) | (أنا) Telomere structure; (ثانيا) Towards the structure of the “30نانومتر” chromatin fibre |
| Peter Roepstorff (Odense, الدنمارك) | (أنا) Application of mass spectrometry in proteomics; (ثانيا) Mass spectrometry in proteomics: assignment of post translational modofications |
| George Thireos (IMBB-FORTH Heraklion, اليونان) | (أنا) Life according to GCN4; (ثانيا) Transcriptional activation: many different orchestrations of the same theme |
| Mathias Uhlen (KTH Stockholm, السويد) | (أنا) Antibody-based proteomics; (ثانيا) A human protein atlas for tissue profiles |
Participants:
Christian Beyschau Andersen (Novo Nordisk, Bagsvaerd,DK);Valerie Anderson (Ithaca, نيويورك);Hwee Ching Ang (كامبريدج,المملكة المتحدة);Rajiv Vaid Bassaiawmoit (Aalborg, DK); Carlos Walter Bertoncini (MPI Goettingen, D);Kate Billings (كامبريدج, المملكة المتحدة); Alessandro Borgia (Roma,IT); Milica Bozic (Belgrade, YU); Iva Hafner Bratkovic (Ljubljana, SO); Martina Chang (فيينا, AU); Niki Chondrogianni (Athens, GR); Elena Cipollini (Bologna, IT); Antonija Cvitkovic (MPI Martinsried, D); Taru Deva (Aalborg, DK); Maria Dontsova (Pushchino, RU); Regina Gonzales Dosal (Aarhus, DK); Elisa Fabiani (Grenoble, F); Kristoffer Famm(كامبريدج, المملكة المتحدة); Ioannis Filippis (MPI Berlin, D); Matthias Futschik (Berlin, D); Silva Giannini (كامبريدج, المملكة المتحدة); Sharon Gilead (Tel Aviv, إيل); Charles Grummit (MRC Cambridge, المملكة المتحدة); Britta H?hn (Berlin, D); Wolfgang Hoyer (MPI Goettingen, D); David Huang (Montreal, كاليفورنيا); Dmitry Ivankov (Pushchino, RU); Paulina Izewska (Lausanne, CH); Kadri Janikson (Tartu, ES); Thomas J?rgensen (Odense, DK); Sviatlana Kananovich(Minsk, Belarus); Alexej Kedrov (Dresden, D); Alexandra Kienast (Heidelberg, D); Mehmet Akif Kilic (Antaly, TU); Mariya Kordysh (Kiev, Ukraina); Trine Rennebod Larsen (Odense, DK); Stina Lindman (Lund, SE); Wheaton Little (MRC Cambridge, المملكة المتحدة); Joao Pedro Lopes (Coimbra, PT); Mantas Malisauskas (Umea, SE); Jia Mi (Uppsala, SE); Sanne Nabuurs (Wageningen, NL); Giovanna Navarra (Palermo, IT); Lise Nesgaard (Aalborg, DK); Candy Wai-Yan Ng(كامبريدج, المملكة المتحدة); Adrian Nickson (كامبريدج, المملكة المتحدة); ?zen ?senzoy (Balekizir, TU); Jadwiga Para (Lodz, PL);Aviv Paz (Rehovot, إيل); Sergio Perez (Bilbao, E); Erez Podoly (Jerusalem, إيل); Johan Rockberg (Stockholm, SE); Anna Rutkowska (Heidelberg, D); Lu Sang (Aarhus, DK); ك. Tanuj Sapra (Dresden, D); G?n?l Seyit (MPI Martinsried, D); Irina Shkundina (Moscow, RU); Anastasia Shorina (Novgorod, RU); Christina Soromani (كامبريدج, المملكة المتحدة); Johanna Steen (Stockholm, SE); Olga Szczepankiewicz (Lund, SE); Karin Tamm (Tallin, ES); Srpil Tanrecerdi(Izmir, TU); Henning Tidow (كامبريدج, المملكة المتحدة); Federico Torta (Parma, IT); Jade Huong Tran (كامبريدج, المملكة المتحدة); Morten Beck Trelle (Odense, DK); Ioannis P. Trougakos (Athens, GR); Murali Karthick Vadivelu (MRC Cambridge, المملكة المتحدة);Martijn van Raaij (Enschede, NL); Lisette Verhoef (Stockholm, SE);Valeria Vetri (Palermo, IT); Catherine Worth (كامبريدج, المملكة المتحدة); Wei-Feng Xue (Lund, SE); Hui Yan (Manchester, المملكة المتحدة); Konstantin B Yenkoyan (Yerevan, Armenia); Daphna Zaaroor (Haifa, إيل); Evgeniy Zadorin (Kiev, Ukraina); Giuliano Zanchetta (Segrate, IT); Tzviya Zeev-ben-Mordehai (Rehovot, إيل).
SPETSES 2006
September 5 ل 15
Molecular Basis of Bacterial Virulence and Survival within Infected Hosts and in the Environment
Organizers: Pascale Cossart (Institut Pasteur, فرنسا); Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية)
Lecturers and Lectures
General Lectures
Julian Davies (University of British Columbia, كندا)
What is an antibiotic ? Discovery, mode of action, biosynthesis, environmental importance
Philippe Sansonetti (Institut Pasteur, فرنسا)
What makes a pathogen, what makes a commensal, at mucosals surfaces ?
Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية)
Exploring microbial diversity
Invasive Bacteria
David Holden (Imperial College, England)
Methods to study Salmonella virulence
Pascale Cossart (Institut Pasteur, فرنسا)
Listeria invasion : from cell biology to pathogenesis
Biodiversity in bacterial pathogens
Pam Small (University of Tenessee, الولايات المتحدة الأمريكية)
Environmental pathogens… what are they, how do you find them, how do they “emerge” and what do they do ?
Jeff Miller (University of California Los Angeles, الولايات المتحدة الأمريكية)
The generation of diversity as a driving force in host-parasite interactions
Intracellular life of bacterial pathogens
David Holden (Imperial College, England)
Intracellular activities of Salmonella
Edgardo Moreno (Universidad Nacional, Costa Rica)
Intacellular life of and death of Brucella
Pascale Cossart (Institut Pasteur, فرنسا)
Actin-based motility of intracellular pathogens
Genetics and genomics
Stephen Lory (Harvard Medical School, الولايات المتحدة الأمريكية)
Genome-wide approaches towards understanding bacterial virulence
Val?rie Mizrahi (University of the Witwatersrand and National Health, South Africa)
The development and application of genetic tools for investigating pathogenesis mechanisms of Mycobacterium tuberculosis
Secretion I
Tony Pugsley (Institut Pasteur, فرنسا)
Putting proteins in their places in microbial cells
Guy Cornelis (Biozentrum der Univerist?t Basel, سويسرا)
The Yersinia Ysc=Yop type III secretion system – Part I : the apparatus
Extracellular bacteria
Gunnar Lindhal (Lund University, السويد)
How streptococcus pyogenes establishes an infection and interacts with the immune system of the host
Patrice Boquet (Facult? de M?decine de Nice, فرنسا)
General Cellular and molecular mechanisms of bacterial toxins
أنظمة
Jeff Miller (University of California Los Angeles, الولايات المتحدة الأمريكية)
Signaling networks and the regulation of bacterial pathogenesis
Stephen Lory (Harvard Medical School)
Enhancement of bacterial virulence by horizontal gene transfer and pathoadaptative mutations
Secretion II
Guy Cornelis (Biozentrum der Universit?t Basel, سويسرا)
The Yersinia Ysc-Yop type III secretion system – Part II : the effectors
Tony Pugsley (Institut Pasteur, فرنسا)
Multi-component bacterial cell envelope motors
Immunity / Inflammation I
Philippe Sansonetti (Institut Pasteur, فرنسا)
Invasion and inflammatory destruction of the intestinal epithelium by Shigella
Arturo Zychlinsky (Max Planck Instit?t f?r Infektionsbiologie, ألمانيا)
Innate Immunity I : sensing bacteria
Immunity / Inflammation II
Gunnar Lindhal (Lund University, السويد)
Antigenic variation – streptococcal M protein as a model system
Pam Small (University of Tenessee, الولايات المتحدة الأمريكية)
Macrolide-mediated virulence in mycobacterial pathogens
Immunity / Inflammation III
Arturo Zychlinsky (Max Planck Instit?t f?r Infektionsbiologie, ألمانيا)
Innate Immunity II : the effectors
Edgardo Moreno (Universidad Nacional, Costa Rica)
How Brucella organisms evade proinflammatory responses and generate chronic infections
Secretion III
Patrice Boquet (Facult? de M?decine de Nice, فرنسا)
Mitochondria as new preys for bacteria: the Helicobacter pylori vacA toxin model
Genome evolution
Val?rie Mizrahi (University of the Witwatersrand and National Health, South Africa)
Mechanisms of genetic adaptation and genome evolution in mycobacteria
Julian Davies (University of British Columbia, كندا)
Antibiotics II : resistance, mechanisms, origins and evolution, solutions
Roberto Kolter (Harvard Medical School, الولايات المتحدة الأمريكية)
Bacteria as multicellular organisms
Participants:
Ackermann, Nikolaus, Munich DE; Baczynska, Agata, Aarhus DK; Barquero, Elias, Madrid E; Beiter, Katharina, Stockholm S; Biedzka-Sarek, Marta, Helsinki FI; Boncompain, Gaelle, Paris F; ب?ttcher, Jan Peter, Berlin DE; BRAWN, Lindsey, Cambridge UK; Brotcke, Anna, Stanford USA; BUSS, Chrisoph, م?nster DE; Cappon, Andrea, Padua I; Charova, Spyridoula, Crete GR; Ciocchini, Andres, Madrid E; Degtyar, Elena, Tel Aviv IR; Disson, Olivier, Paris F; Eilers, Bj?rn, Berlin DE; Elazar, Sharon, Jerusalem IR; ESSID, Miriam, Geneva CH; Fevre, Cindy, Paris F; Fuchs, Tobias, Berlin DE; Hagman, Arne, Paris F; HAIKKO, Johanna, Helsinki F; Hamon, م?lanie, Paris F; Hejnova, Jana, Prag CZ; Hodak, ح?l?ne, Lille F; Jaumouill?, Valentin, Paris F; Jelsback, Lotte, Copenhagen DK; JENNER, Dominic, المملكة المتحدة; Jonas, Kristina, Stockholm S; Jude, Brooke A., Dartmouth UK; Konradt, Christoph, Paris F; Kuijl, Coen, Amstserdam NL; KUMAR, Anil, Dehli IN; KUMAR, Santosh, CDFD IN; Lee, Baoleri, DK; Mally, Manuela, Basel CH; MANCEK KEBER, Mateja, Ljubljana SLO; Marin Munoz, Elvira, CSIC E; Marlow, Victoria, Edinburgh UK; Monk, Ian, Cork UK; Monson, Rita, Cambridge UK; MOSI, Lydia, Tenesse USA; Mueller, Catherine, Basel CH; Nagai, Takeshi, Tokyo JP; Nehme, Nadine, Strasbourg F; Nogueira, Patricia, CEPEM BR; Odendall, Charlotte, London UK; Panina, Ekaterina, Los Angeles USA; Papatheodorou, Panagiotis, Hohenheim DE; Persson, Jenny, Lund S; Poyraz, Omer, Berlin DE; Puhar, Andrea, Padua I; Ramos Vivas, Jos?, Paris F; Ramsden, Amy, London UK; Rasmussen, Louise Caroe Vohlander, Aarhus DK; Raupach, ب?rbel, Berlin DE; Reig, Nuria, Geneva CH; Rosini, Roberto, Chiron; Ruer, س?gol?ne, CNRS F; Sakugari, Yumiko, DK; Santi , Isabella, IRIS, Chiron; Scavone, Paula, IIBCE UY; Scherr, Nicole, Basel CH; Schneider, Muriel, London UK; Sieira , Rodrigo, UNSAM AR; Simeone, Roxane, CNRS F; Suzuki, Masato, Tokyo JP; Van der Meer, Ynske, Utrecht University; Vergara, Marta, CSIC E; Viklund, Ing-Marie, Stockholm S; VILLWOCK, Andrea, دبليو?rzburg DE; VIVES FLOREZ, Martha, Universidad de los Andes CO; Vlisidou, Isabella, Bath UK; Vogt, Guillaume, ح?pital Necker F; Warner, Digby, MRC/NHLS/WITS ZA; Wartha, Florian, Stockholm S; WATSON, Robert, Bath UK; Wladyka, Benedykt, Jagiellonian University PL; Yim, Grace, British Columbia CA; ZAVIYALOV, Andrey, CNRS FI.
SPETSES 2007
August 31 – September 9
Molecular Mechanisms of Regeneration
Organizers: Peter Angel (Heidelberg), Horst Feldmann (Munich), Peter Herrlich (Jena) chairman, Herbert J?ckle (G?ttingen), Benjamin Kaupp (ج?lich), Erwin Wagner (فيينا)
Lecturers and Lectures
أ. Basic Cell Biology
Signal Transduction
Peter Herrlich (Jena)
Regulation of signal transduction
Axel Behrens (لندن)
Identification of coactivators linking the AP-1 transcription factor to growth factor and DNA damage signaling
Ueli Schibler (جنيف)
The circadian timing system: a web of cell-autonomous oscillations
Protein Folding and Processing
Walter Birchmeier (Berlin)
Wnt/beta-catenin signalling
Christof Niehrs (Heidelberg)
Wnt signalling
Ronald P. ك?hnlein (G?ttingen)
Energy homeostasis in flies
Bernd Bukau (Heidelberg)
Regeneration of proteins by molecular chaperones
علم الوراثة اللاجينية
Peter Becker (Munich)
Chromatin dynamics: ATP-dependent nucleosome remodelling and beyond
Konrad Hochedlinger (Harvard)
Transcription factor induced epigenetic programming
Peter Becker (Munich)
Dosage compensation in Drosophila: vital fine-tuning of transcription
Signal Transduction and Cancer
Michael Karin (La Jolla)
The IKK complex: providing a link between inflammation and cancer (two lectures)
ب. بيولوجيا الخلايا الجذعية
Spermatogenesis and planarian regeneration
Benjamin Kaupp (ج?lich)
Ca2+ oscillations and chemotactic signaling in sperm
Aziz Aboobaker (Nottingham)
(أنا) An introduction to the planarian system for regeneration and stem cell research
(ثانيا) Positional signalling and remodelling on planarians
Christof Niehrs (Heidelberg)
DNA demethylation, DNA repair and pluripotency
الخلايا الجذعية الجنينية
Gordon Keller (نيويورك)
(أنا) Lineage specific differentiation of embryonic stem cells
(ثانيا) Organ regeneration
Konrad Hochedlinger (Harvard)
ES cell biology
الخلايا الجذعية السرطانية
Eric Lechman (Toronto)
(أنا) Stem cell and leukemic stem cell concepts
(ثانيا) miRNA in leukemic stem cell biology
Piet Borst (Amsterdam)
(أنا) Mechanisms of drug resistance in tumors: the role of apoptosis resistance and of tumor stem cells
(ثانيا) DNA repair and cancer chemotherapy
الخلايا الجذعية البالغة
Ueli Schibler (جنيف)
Outputs of the circadian clock: from xenobiotic detoxification to liver regeneration
Maria Sibilia (فيينا)
EFGR signalling in development, regeneration and cancer
Andreas Trumpp (Epalinges)
(أنا) The role of Myc in stem cells during dvelopment, homeostasis and disease
(ثانيا) Dormant and activated stem cells during homeostasis injury and cancer
ج. Organogenesis and Organ Restoration
Thomas Jenuwein (فيينا)
Epigenetic control by histone methylation
Leonhard Rudolph (Hannover)
Telomere dysfunction induces cell intrinsic checkpoints and environmental alterations limiting cell function
Erwin Wagner (فيينا)
(أنا) Liver regeneration, inflammation and liver cancer: functions of Jun/AP-1 and JNK/p38 kinases
(ثانيا) Bone and skin dvelopment controlled by AP-1 (Fos/Jun)
Thomas Braun (Bad Nauheim)
Mechanisms of striated muscle regeneration: stability of lineage decisions in mesodermal derivatives
Carmen Birchmeier (Berlin)
The c-met receptor functions in adult regeneration of rat liver and skin
ج?rg Huelsken (Epalinges)
Cancer stem cell maintenance in the skin is dependent on beta-catenin signalling
D. Neuronal Stem Cells
Axel Behrens (Nottingham)
Mechanisms of transcriptional regulation during neurodegeneration and cancer
Carmen Birchmeier (Berlin)
Muscle progenitors and satellite cells
Wieland Huttner (Dresden)
The cell biology of neural stem and progenitor cells:
(أنا) Symmetric versus asymmetric divisions
(ثانيا) Molecular mechanisms
E. Ageing
Thomas Braun (Bad Nauheim)
How do hearts cope with ageing and stress? The role of sirtuin longevity molecules and oxidative stress
Peter Herrlich (Jena)
Introduction into molecular mechanisms of ageing: a new vertebrate ageing model
Participants:
Abranches, Elsa (Lisbon); Alexandrova, Svetlana (Moscow); Alpern, Danil (Moscow); Andersin, Temu (جنيف); Araujo, Ines (Coimbra); Archacka, Karolina (وارسو); Arends, Brigitte (Utrecht); Baptista, Pedro Miguel (Wake Forest); Blassberg, Robert (لندن); Boehnke, Karsten (Heidelberg); Boros, Katalin (Manchester); Buhl, Sandra (Bonn); Carreira, Bruno (Coimbra); Centanin, Lazaro (Heidelberg); Chioni, Athina-Myrto (Barts); Cizkova, Dana (Prague); Costa Silva Alvaro, Ana Rita (Coimbra); Darr, Henia (Jerusalem); Denzel, Martin (La Jolla); Diaz Garcia, Sandra (Madrid); Diefenbacher, Markus (Karlsruhe); Ditadi, Andrea (Padua); Durchdewald, Moritz (Heidelberg); Dvinge, Heidi (كامبريدج); Ferrer Vaquer, Anna (Freiburg); Frade Marquez, Maria (Coimbra); G?rm?ق, Uzay (Istanbul); Gorsic, Masa (Ljubljana); Grinevich, Yekatarina (Almaty); Harasim, Thomas (Martinsried); Hefferman, Theresa (Dublin); Heidemann, Martin (Munich); Henriques Oliveira, Ana Catarina (Coimbra); Illing, Anett (Jena); Jurisch, Natalie (Heidelberg); Kajahn, Jennifer (L?beck); ك?nel, Philipp (Bern); Kapralova, Irina (Moscow); Khatuntseva, Svetlana (Moscow); Korolija, Marina ( Zagreb); Kovalenko, Oksana (Kiev); Kozlova, Alyona (Moscow); Kragl, Martin (Dresden); Krasteva, Natalia (Sofia); Kruse, Julia (Bad Nauheim); Le Martelot, Gwendal (جنيف); Martin-Duque, Pilar (Madrid); Mauricio de Sousa, Sara Cristina (Oeiras); Merkel, Ulrike (Jena); Miroshnychenko, Daria (Kiev); Mocan, Elena (Moldova); Nacu, Eugen (Dresden); Nemeth, Andrea (Budapest); Otto, Anthony (Reading); Papadopoulos, Dimitrios (Basle); Pelucchi, Paride (Segrate); Perepelyuk, Maryna (Kiev); Petrova, Rushana (Moscow); Rosa da Silva, Ana Cristina (Coimbra); Saini, Camille (جنيف); Sanzone, Sveva (Segrate); Scheuermann, Johanna (Heidelberg); Sch?ntaler, Helia (فيينا); Schotanus, Baukje (Utrecht); Schroeder, Arnold (Freiburg); Schwamborn, Jens (فيينا); Seitzer, Nina (Martinsried); Shakhbazau, Antos (Belarus); Skouloudaki, Kassiani (Freiburg); Snippert, Hugo (Utrecht); Spee, Bart (Leuven); Sroczynska, Patrycia (Manchester); Suvorava, Tatsiana (Belarus); van Wijk, Bram. (Amsterdam); Varga, Nora (Budapest); Voskanyan, Zaruhi (Erevan); Winkhaus, Friederike (ج?lich); Yenkoyan, Konstantin (Erevan).
SPETSES 2008
September 11-18
New Developments in Quantitative Molecular Bioscience
21 lecturers, 19 tutors, 120 students
Organizers: John McCarthy (UMIST Manchester; chair)
Lecturers and Lectures:
Participants:
No detailed information available
SPETSES 2009
September 7 – 17
Proteins and Their Networks – From Specific to Global Analysis
Organizers: Alan R. Fersht (Cambridge University, المملكة المتحدة; chairman), Daniela Roberts (MRC Cambridge, المملكة المتحدة), Mathias Uhlen (Stockholm),
Administrative Co-ordinator:Paula Murphy (كامبريدج, المملكة المتحدة)
Lecturers and Lectures
Ruedi Aebersold, ETH Zurich, Institute of Molecular Systems Biology, سويسرا. Protein Mapping using MS.
Protein Mapping using MS 1,2
Patrick Aloy, Institute for Research in Biomedicine, برشلونة, إسبانيا. Protein-Protein Interactions in the Cell; Structural Bioinformatics
Protein-Protein Interactions in the Cell 1, 2
Madan Babu, MRC Laboratory of Molecular Biology, كامبريدج, المملكة المتحدة. Transcriptional regulatory networks
Transcriptional regulatory networks 1, 2
Wolfgang Baumeister, Max Planck Institute of Biochemistry, Department of Structural Biology, Martinsried, ألمانيا. Whole Cell Tomography
Whole Cell Tomography 1,2
Aaron Ciechanover, Department of Biochemistry, Technion-Israel Institute of Technology, Haifa, Israel. Ubiquitin Systems
Ubiquitin Systems in Biology
Jan Ellenberg, European Molecular Biology Laboratory, Heidelberg, ألمانيا. High-throughput fluorescence microscopy for systems biology
High-throughput fluorescence microscopy for systems biology 1, 2
Alan Fersht, MRC Centre for Protein Engineering and University of Cambridge, كامبريدج, المملكة المتحدة. p53 Tumour Suppressor, Protein Folding
Tumour suppressor p53: from structure to drug discovery 1, 2
Joerg Hoheisel, Deutsches Krebsforschungszentrum, Heidelberg, ألمانيا. High-throughput analysis of cancers; Functional Genome Analysis
High-throughput analysis of cancers 1, 2
Batsheva Kerem, The Department of Genetics, Jerusalem, Israel. Genetics and Disease
Genetics and disease 1,2
Daniela Rhodes, MRC Laboratory of Molecular Biology, كامبريدج, المملكة المتحدة. Chromatin and Telomere Structure.
Chromatin Structure
Carol Robinson, Department of Chemistry, University of Cambridge, المملكة المتحدة. Mass Spectroscopy
Mass Spectrometry of Protein Complexes 1,2
Mathias Uhlen, Department of Biotechnology, Royal Institute of Technology, Stockholm, السويد. Human Protein Atlas
Human Protein Atlas 1, 2
Participants:
Eyal Arbely, كامبريدج, المملكة المتحدة; Elvan Arslan, باريس, فرنسا; Anush Bakunts, Pushchino, روسيا; Wiktor Banachewicz, كامبريدج, المملكة المتحدة; Isabelle Bergiers, Louvain-la-Neuve, بلجيكا; Florian Brandt, Martinsried, ألمانيا; Tobias Brandt, كامبريدج, المملكة المتحدة; Sarah Burge, كامبريدج, المملكة المتحدة; Varodom Charoensawan, كامبريدج, Alexander Chernorudskiy, Nizhny Novgorod, روسيا; Celestine Chi, Uppsala; Claus Christensen, Copenhagen N, الدنمارك; Jan van Dieck, كامبريدج, المملكة المتحدة; Evgeny V. Dvoretsky, Moscow; Ksenia Egorova, Moscow; Armida Fabius, Amsterdam; Mar?a Marta Garc?a Alai, كامبريدج, المملكة المتحدة;Javier Garcia, Heslington, York, المملكة المتحدة; Elizabeth M. Gardner, لندن; Shirin Dattatraya Ghodke, Aarhus, الدنمارك; Miriam Goyder, لندن; Giovanna Grimaldi, Chieti, إيطاليا; Felix Halbach, Martinsried, ألمانيا; Michal Harel, Rehovot, Israel; Zvi Hayouka, Jerusalem, Israel; William P. Heal, لندن; Anne Hempelكامبريدج, المملكة المتحدة; Barbara Hjelm, Stockholm, السويد; Eva Hradetzky, كامبريدج; Phillip Hundeshagen, Heidelberg, ألمانيا; Alexander Ivliev, Moscow, روسيا; Sarath Chandra Janga, كامبريدج; Maria (Jensen) Andreasen, Aarhus C – الدنمارك; Joe Kaplinsky, لندن; Jekaterina Kazantseva, Tallinn, Estonia; Andrea Kiss, Debrecen, Hungary; Christi Laur, Tallinn, Estonia; Lina Leinartaite, Stockholm, السويد; Christian L?ث, Stockholm, السويد; John L?fblom, Stockholm Sweden;Jenifer Lum, كامبريدج, المملكة المتحدة; Rafal Marszalek, لندن; Gabriela Vaz Meirelles, Campinas, س?o Paulo, Brazil; Margherita Miele, لندن; David Minde, Utrecht, The Netherlands, Elizabeth Rozalia Morris,Nottingham, المملكة المتحدة; Angela Morrone, Rome, إيطاليا; Aurelio A. Moya-Garc?أ, م?laga. إسبانيا; Lavinia Nardinocchi, Rome, إيطاليا; Antonina Nakalska, وارسو, بولندا; Johan Nilvebrant, Stockholm, السويد;Veronika Ostatn?, Brno, Czech Republic; Hanka Paulitschke, Utrecht, The Netherlands; Rafal Pawlowski, لندن, المملكة المتحدة; Lauri Peil, Tartu, Estonia; Tina Perica, كامبريدج; Miriana Petrovich, كامبريدج;John Phillips, لندن; Anne Pink, Tallinn, Estonia; Rosa Puca, Rome, إيطاليا; Anita Rea, Nottingham, المملكة المتحدة; Tomasz Religa, Toronto, كندا; Christiane Riedinger, Oxford, المملكة المتحدة; Johan Rockberg, Stockholm, السويد; Madeleine Ross, CambridgeM Shahar Rotem, Jerusalem, Israel; Robert Sade, Cambridge UK; Ali Salehi-Reyhani, لندن; Sara Sandin, كامبريدج, المملكة المتحدة; Akuma Divine Saningong, Essen, ألمانيا; Thomas Seaby, لندن; Elena Smekalova, Moscow, روسيا; Henning Tidow Aarhus C, الدنمارك; Kairit Tints, Tallinn, Estonia; Jeremy Touati, Lausanne, سويسرا; Maria Angeles Vazquez Sanchez, برشلونة, إسبانيا; Maryna Veremieva, Kiev , Ukraine; Alicja Warowicka, Poznan Poland;Konstantin Yenkoyan, Yerevan, Armenia; Maryna Zhylinskaya, Tallinn , Estonia.
Spetses Summer Schools, Biotechnology Education, and the Future of Medicine
Spetses Summer Schools are an important part of the global scientific ecosystem, providing advanced education in fields such as molecular biology, genomics, and regenerative medicine. These programs help shape the future of research by connecting young scientists with leading experts and cutting-edge knowledge.
في نفس الوقت, advances in التكنولوجيا الحيوية و العلاج بالخلايا الجذعية are transforming modern healthcare. في أ biotechnology laboratory in Barcelona, إسبانيا, research focuses on the application of الخلايا الجذعية الوسيطة for immune modulation, إصلاح الأنسجة, and treatment of complex diseases.
The integration of scientific education, biomedical research, و clinical innovation represents a powerful direction for the future. As global collaboration continues to grow, programs like Spetses Summer Schools play a key role in advancing both knowledge and medical progress.
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