Soyut
Arka plan
Kök hücre tedavisi is becoming an emerging therapeutic option for chronic liver disease (CLD). Fakat, whether Kök hücre tedavisi is more effective than conventional treatment remains questionable. We performed a large-scale meta-analysis of randomized controlled trials (RCTs) to evaluate the therapeutic effects and safety of Kök hücre tedavisi for CLD.
Methods
We systematically searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov databases for the period from inception through March 16, 2020. Primary outcomes were all-cause mortality and adverse events related to Kök hücre tedavisi. Secondary outcomes included the model for end-stage liver disease score, total bilirubin, albumin, alanine aminotransferase, prothrombin activity, and international normalized ratio. The standardized mean difference (SMD) and odds ratio (OR) ile 95% confidence interval (CI) were calculated using a random-effects model.
Sonuçlar
Twenty-four RCTs were included and the majority of these studies showed a high risk of bias. The meta-analysis indicated that compared with conventional treatment, Kök hücre tedavisi was associated with improved survival and liver function including the model of end-stage liver disease score, total bilirubin, and albumin levels. Fakat, it had no obvious beneficial effects on alanine aminotransferase level, prothrombin activity, and international normalized ratio. Subgroup analyses showed Kök hücre tedavisi conferred a short-term survival benefit for patients with acute-on-chronic liver failure (ACLF), a single injection was more effective than multiple injections, hepatic arterial infusion was more effective than intravenous infusion, and bone marrow-derived stem cells were more effective than those derived from the umbilical cord. Thirteen trials reported adverse events related to Kök hücre tedavisi, but no serious adverse events were reported.
Conclusions
Kök hücre tedavisi is a safe and effective therapeutic option for CLD, while patients with ACLF benefit the most in terms of improved short-term survival. A single injection administration of bone marrow-derived stem cells via the hepatic artery has superior therapeutic effects.
