Terapia com células-tronco & Pesquisa Clínica
Tradução clínica de terapias experimentais com células-tronco neurais
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation Highlights •NSCs from somatic tissues or direct reprogramming equally repress neuroinflammation •Extracellular succinate activates SUCNR1/GPR91 on NSCs •Activated NSCs secrete PGE2 and scavenge succinate, assim reprogramando o tipo 1 MPs •Sucnr1 mutant NSCs have reduced anti-inflammatory activity after transplantation Leia mais
