Terapia com células-tronco da epilepsia .
A epilepsia, como um dos distúrbios neurológicos mais comuns, afeta mais de 50 milhões de pessoas em todo o mundo com uma taxa de prevalência mais elevada em países de baixo rendimento. Descargas elétricas excessivas em neurônios após dano ou perda de células neurais causam convulsões recorrentes. One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (TLE) which results from hippocampal sclerosis. Nowadays, similar to other diseases, epilepsy also is a candidate for treatment with different types of stem cells.
Various stem cell types were used for treatment of epilepsy in basic and experimental researches.
Two Stem cell therapy has been shown efficacious in treating experimental models of neurological disorders, incluindo doença de Parkinson, and neuropsychiatric diseases, such as depression
Major roles of stem cell therapy in epilepsy are prophylaxis against chronic epilepsy and amelioration cognitive function after the occurrence of TLE.
Células-tronco pluripotentes induzidas (iPSCs)
Some epilepsies are caused because of a genetic mutation or change in neurons. Por exemplo, Dravet syndrome is a devastating form of childhood epilepsy caused by a mutation in a specific sodium channel.
Scientists have found a way to take stem cells from people with Dravet syndrome and program them to become any type of cell in the body. These new cell types are called pluripotent stem cells. These new cells can be made into neurons.
Although much more research needs to be done, stem cell therapy is an attractive and promising treatment for epilepsy.
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