干细胞疗法

干细胞在理解和治疗一系列疑难杂症方面显示出巨大的前景, 受伤和其他健康相关状况. 涉及干细胞的临床试验正在进行中, 每一天,研究人员都离另一个医学突破更近了一步.

干细胞作为患者的修复疗法已显示出令人鼓舞的潜力

当前的评论总结了使用干细胞疗法的当前证据. 不同类型干细胞疗法的安全性和可行性似乎已得到合理证明,所有临床数据均包含在全球数据库 ClinicalTrials.gov 中 (美国)

https://临床试验.gov/ct2/results?术语=自体+间充质+干细胞+细胞&搜索=申请&记录=e&年龄_v=&地德=&类型=&RSLT

我们检查了 NIH ClinicalTrials.gov 和欧洲数据库中的临床试验报告,根据干细胞类型和疾病应用对它们进行分类.

我们搜索了同行评审期刊上发表的临床试验数据,并查找了有关公司进行的试验的公开信息. 一些研究的数据定期发布, 但对于许多试验而言,数据不可用或不易获取. 鉴于细胞治疗领域相对不成熟, 了解早期临床试验的结果以帮助指导其他人参与这一过程非常重要.

 

间充质干细胞治疗肝病和糖尿病

终末期肝病的肝脏 (肝硬化) 由于乙型和丙型肝炎以及酒精和隐源性原因,通过肌酐变化评估,显示出一些功能反应, 血清白蛋白, 和胆红素对自体 MSC 的反应 (埃尔-安萨里等人。, 2012, 卡拉齐哈等人。, 2009).

https://www.scopus.com/record/display.uri?eid=2-s2.0-84865572084&origin=inward&txGid=3bb6ff45ee5d0283d570c619974280ea

https://www.scopus.com/record/display.uri?eid=2-s2.0-70349733505&origin=inward&txGid=f604a98d49bc5fe77d638ea87714d97f

The anti-fibrotic effects of autologous MSCs (which were 50 million MSCs administered on two occasions 4 weeks apart) were explored in patients with alcoholic liver cirrhosis (Jang et al., 2014). Improvements in histological liver biopsy samples were observed in 55% patients as well as some change in type-1 collagen and α-smooth muscle actin.

https://www.scopus.com/record/display.uri?eid=2-s2.0-84890127523&origin=inward&txGid=182e4249e99692e1435d6431de0fdc41

糖尿病

Diabetes is classified into two main types (type 1 并输入 2) which both lead to hyperglycemia .

Types of diabetes

  1. Type 1 Diabetes is the result of a person’s immune system fighting and destroying the b-cells, it usually begins in the early stages of life and accounts for 10% of the total cases of diabetes. People with this type have to take insulin shots daily in order to survive.
  2. Type 2 Diabetes results from b-cell performance decline and an increase in insulin resistance; this type is linked with genetic factors and obesity, hence this type can be prevented by living a healthy lifestyle.
  3. There is another type of diabetes that affects pregnant women, it is called Gestational Diabetes where the hormones released by the placenta to sustain the pregnancy, make the pregnant woman’s cells more resistant to insulin. Once the pancreas is unable to overcome the resistance, the patient develops diabetes

糖尿病 干细胞治疗

这些年来, there have been attempts to cure diabetes by using methods like replacing b-cells through transplants, by increasing b-cell replication, by reducing the death of b-cells and by deriving new b-cells from other cells.

Autologous Mesenchymal stem cells (间充质干细胞) 是自我更新的多能细胞,具有分泌多种生物因子的能力,可以恢复和修复受损的组织.

众所周知,间充质干细胞在修复受损组织中发挥着至关重要的作用. 它们可以分化以替换死亡细胞,并分泌刺激因子来激活微环境中的周围细胞, 增强组织修复过程. 所以, 间充质干细胞可用于治疗因慢性高血糖而受损的组织. MSC 移植可通过以下作用增加 β 细胞质量:

(1) 通过细胞分化替代β细胞;

(2) 通过产生细胞因子来改变局部微环境, 趋化因子和刺激内源再生的因子;

(3) 减少或预防β细胞的自身免疫. Immunomodulatory and inflammatory effects of MSCs also contribute to the reduction of insulin resistance.

Results achieved with 干细胞疗法

  • Significant decrease in fasting blood sugars and the level of Hemoglobin A1C
  • Significant decrease in Triglyceride levels
  • Measurable improvement in kidney function with a decrease in creatinine levels

Clinical studies are underway using MSCs in patients with diabetes.

Data suggest positive changes in metabolic parameters may occur with intravenous injection MSCs

众所周知,间充质干细胞在修复受损组织中发挥着至关重要的作用. 它们可以分化以替换死亡细胞,并分泌刺激因子来激活微环境中的周围细胞, 增强组织修复过程

The recent progress in regenerative medicine, especially 干细胞疗法, has suggested several novel and potential cures for (Diabetes Type 1) T1D. Autologous mesenchymal stem cell (MSC) based cell therapy is among one of them. MSCs are a type of adult stem cells residing in bone marrow, 脂肪组织, umbilical cord blood, and many other tissues. 间充质干细胞, with self-renewal potential and transdifferentiation capability, can be expanded in vitro and directed to various cell lineages with relatively less efforts. MSCs have well-characterized hypoimmunogenicity and immunomodulatory effect. All these features make MSCs attractive for treating T1D.

For both T1DM and T2DM, autologous MSC transplantation can dramatically improve the blood glucose levels, while reducing the insulin dose and side effects associated with DM. More importantly, both in preclinical trials and clinical trials, autologous MSC transplantation has been demonstrated to be safe; there have been no observed adverse side effects or tumorigenesis. The data thus far have suggested that MSC transplantation is a promising therapy for DM

https://www.ncbi.nlm.nih.gov/pubmed/24641956

https://clinicaltrials.gov/ct2/show/NCT01719640?term=autologous+autologous mesenchymal+stem+cells&记录=e&draw=8&rank=80

https://clinicaltrials.gov/ct2/show/NCT01759823?term=autologous+autologous mesenchymal+stem+cells&记录=e&draw=9&rank=84

Efficacy of autologous stem cell transplantation in patients with type 2 diabetes mellitus.

Our observations indicate that SCT is a safe and effective modality of treatment to improve beta-cell function in patients with T2DM.

https://www.ncbi.nlm.nih.gov/pubmed/19686048

MSC treatment demonstrated exciting therapeutic effects on glycemic control by restoring islet function and ameliorating insulin resistance

 

Stem cell therapies in clinical trials in stroke

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0643-x

Osteoarthritis and knee pain

Feasibility and safety were confirmed, and strong indications of clinical efficacy were identified. 患者的算法功能指数表现出快速和渐进的改善,接近 65% 到 78% 经过 1 年. 间充质干细胞疗法可能是慢性膝骨关节炎的有效替代疗法. 干预很简单, 不需要住院或手术, 缓解疼痛, 并显着改善软骨质量.

骨关节炎患者关节内注射间充质干细胞使绝大多数治疗病例的软骨覆盖和质量得到了显着改善 (奥罗斯科等人。, 2013)

https://www.scopus.com/record/display.uri?eid=2-s2.0-84880131240&origin=inward&txGid=2f3f3afd337388490dba840f6f46b91d

背疼

因退行性椎间盘疾病而导致严重背痛的患者显着改善, 和 71% 改善疼痛和残疾临床参数的最佳效率, 但没有椎间盘高度恢复 (奥罗斯科等人。, 2011).

https://www.scopus.com/record/display.uri?eid=2-s2.0-80053324854&origin=inward&txGid=73ccd5ee9116417a578acaaa6e89af1d

Mesoblast has also reported the benefits of a single injection of MSCs (6 或者 18 million) in a randomized, placebo-controlled phase II study of 100 patients with chronic low back pain due to degenerative disc disease. A single injection of 6 million MSCs gave substantial and sustained pain relief with 48% having no or minimal pain after 24 months compared with only 13% of patients without pain who received saline control injections (Mesoblast, 2015)

勃起功能障碍

Clinical trial results show that stem cells can restore sufficient erectile function to allow previously impotent men to have spontaneous intercourse. This is the first time 干细胞疗法 has produced patients who have recovered sufficient erectile function to enable intercourse.

https://www.sciencedaily.com/releases/2017/03/170327083718.htm

在 2016, 来自丹麦的 Haahr 等人报告了干细胞注射自体 ADSC 的安全性和潜在效果

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209555/

多发性硬化症

超过一半的多发性硬化症患者患有以累积残疾为特征的进展性疾病. 缺乏针对进行性多发性硬化症的治疗是一个重大的未满足的临床需求. 有证据表明自体间充质干细胞对急性和慢性多发性硬化症动物模型具有有益作用, 我们的目的是评估这些细胞作为继发性进行性多发性硬化症潜在神经保护治疗的安全性和有效性.

在我们的研究中,自体间充质干细胞被安全地给予继发性进行性多发性硬化症患者. 结构性证据, 功能性的, 治疗后某些视觉终点的生理改善表明有神经保护作用.

https://www.ncbi.nlm.nih.gov/pubmed/23061813?dopt=Abstract

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(11)70305-2/abstract

干细胞治疗 用于莱姆病

脑, 神经系统, 心, 循环, 肌肉, 关节, 生殖系统, 消化系统和皮肤是慢性莱姆病的目标部位. 有时症状甚至需要数年时间才能出现,并且无法预测它们何时出现. 这些困难很难解决, 让患者感到疼痛并无法进行日常活动.

新的 干细胞疗法 is a discovery that is extremely helpful to all the Lyme disease patients whose condition progressed and left them with damage that causes symptoms that cannot be solved.

. They are a part of a repair system and during this procedure they are enriched and their number enlarged, which is why they are able to rebuild damaged areas inside organism more, in a completely natural way, reversing the symptoms of a condition.

自体 干细胞治疗 is completely safe

Stem cells are undifferentiated cells that are give rise to differentiated cells that make up the building blocks of tissue and organs. Due to their unlimited source and high differentiation potential, autologous stem cells are considered as potentially new therapeutic agents for the treatment.

During past few years a considerable progress in stem cell-based strategies whole body regeneration have been proposed as future clinical therapies.

现在, most procedures involve injections of stem cells to peripheral blood like a blood transfusions.

When stem cells are infused into the patient, they are administered through an intravenous catheter (四号) just like a blood transfusion.

Pre-Treatment Evaluation

A stem cell specialist will begin the evaluation by reviewing your medical record and history, performing anti-aging treatment he will recommend a treatment plan.

Preadmission Tests

Before being admitted to the clinic, you will have laboratory and other diagnostic tests to determine if you have normal function of the heart, 肺, kidney and liver and that you do not have an undiagnosed infection. Most of these tests will be done as an outpatient before you are admitted to the clinic, but others may need to be completed after you are admitted for treatment.

Stem Cells injections.

When stem cells are infused into the patient, they are administered through an intravenous catheter (四号) or central venous catheter, just like a blood transfusion .

Expectations.

It is expected strengthening the regenerative abilities of the body, improving of all functions of organs and tissues and repairing of pathologically damaged tissues, rejuvenate body.

The approximate maximum of stem cell efficiency is 2 months after injection with the subsequent long-term effect.

Recommendations

It is recommended do not use antibiotics for several weeks after stem cells injections.

It is not recommended to visit sauna for 1-2 周,  avoid strong physical activity, stresses and any kind of trauma within 2 months after stem cells injections.

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