Stem Cell Therapy for Cholestasis: An Overview
Cholestasis, a condition characterized by impaired bile flow, can lead to liver damage and fibrosis. Current treatment options are limited and often ineffective. Terapia com células-tronco has emerged as a promising approach for cholestasis treatment, oferecendo o potencial para regeneração de tecidos e restauração funcional.
Current Challenges in Cholestasis Treatment
Conventional cholestasis treatments, such as ursodeoxycholic acid and cholestyramine, provide symptomatic relief but do not address the underlying cause. Liver transplantation is the only curative option for end-stage cholestasis, but it is limited by donor availability and the risk of complications.
Stem Cells as a Potential Therapeutic Option
Stem cells possess the ability to self-renew and differentiate into various cell types. Their regenerative potential makes them an attractive therapeutic option for cholestasis, where damaged liver cells can be replaced or repaired. Stem cells can be derived from various sources, incluindo medula óssea, tecido adiposo, e sangue do cordão umbilical.
Types of Stem Cells for Cholestasis Treatment
Different types of stem cells have been investigated for cholestasis treatment. Células-tronco mesenquimais (MSC) are multipotent cells that can differentiate into various cell types, including liver cells. Hepatic stem cells (HSCs) are liver-specific stem cells that can regenerate liver tissue. Células-tronco embrionárias (CES) are pluripotent cells that can differentiate into any cell type in the body.
