Stem Cell Treatment for Viral Hepatitis: A Comprehensive Overview
Viral hepatitis, a global health concern, afeta milhões em todo o mundo. Traditional therapies have limitations, necessitating the exploration of novel approaches. Terapia com células-tronco has emerged as a promising treatment modality, offering potential for disease modification and regeneration.
Current Therapeutic Approaches and Challenges
Current treatments for viral hepatitis include antiviral medications, interferon therapy, and liver transplantation. While these approaches can suppress viral replication and improve liver function, they often have limited efficacy, high cost, and potential side effects. Liver transplantation, the most invasive option, is only applicable to a small number of patients due to organ shortage and high post-operative risks.
The Role of Stem Cells in Hepatitis Management
Células-tronco, with their ability to self-renew and differentiate into various cell types, hold immense therapeutic potential for viral hepatitis. Preclinical studies have demonstrated that stem cells can differentiate into hepatocytes and cholangiocytes, the functional cells of the liver. By replacing damaged liver cells, stem cells may restore liver function and reduce inflammation. Adicionalmente, stem cells secrete growth factors and cytokines that promote liver regeneration and immune modulation.
